Recombinant Human Probable DNA dC->dU-editing enzyme APOBEC-3B (APOBEC3B)

1. the knockdown of APOBEC3B by clustered regularly interspaced short palindromic repeats/CRISPR associated protein 9 resulted in reduced proliferation and enhanced chemosensitivity of glioma cells. Thus, APOBEC3B contributes to glioma progression and may be a future target for therapeutic intervention. PMID: 30226610
2. results suggest that B-Myb-A3B contributes to DNA damage and could be targeted by inhibiting EGF receptor. PMID: 28276478
3. APOBEC3A/B deletion was associated with young age at diagnosis among the cancer cases for both cancer forms (lung cancer: P = 0.02; dominant model and prostate cancer PMID: 29140415
4. These studies combine to indicate that APOBEC3B promotes drug resistance in breast cancer and that inhibiting APOBEC3B-dependent tumor evolvability may be an effective strategy to improve efficacies of targeted cancer therapies. PMID: 27730215
5. Our results provide evidence that APOBEC3B can interact with HBV core protein and edit HBV DNAs during reverse transcription. These data suggest that APOBEC3B exerts multifaceted antiviral effects against HBV. PMID: 29129707
6. review of current understanding of APOBEC3A and APOBEC3B biology in human papillomavirus Infection restriction, evolution, and associated cancer mutagenesis PMID: 28825669
7. This study found that A3B C-terminal domain shows higher activity toward its target sequence in short ssDNA and efficiently deaminates a target sequence located near the center of ssDNA. PMID: 28952713
8. Data show that the larger oligomeric state of APOBEC3B (A3B) inhibited its activity. PMID: 28981865
9. APOBEC3B*c.783delG showed evidence of modest association with breast cancer and seemed to contribute to earlier onset of the disease. PMID: 28062980
10. Data show that APOBEC3B (A3B) expression is inversely related to p53 status in different cancer types and demonstrate that this is due to a direct and pivotal role for p53 in repressing A3B expression. PMID: 28977491
11. Structural determinants of APOBEC3B non-catalytic domain for molecular assembly and catalytic regulation have been reported. PMID: 28575276
12. A lysine-free derivative of human APOBEC3B was constructed and shown to be indistinguishable from the wild-type enzyme in DNA cytosine deamination, HIV-1 restriction, and nuclear localization activities. PMID: 28841445
13. exposures to relevant environmental factors might induce APOBEC3A or APOBEC3B expression above genotoxic levels and initiate tumorigenesis in a tissue-specific manner in the right cellular environment where ssDNA is available PMID: 27643540
14. APOBEC3B expression increased the incorporation of genomic uracil, invoked DNA damage response (DDR) biomarkers and caused cell cycle arrest. PMID: 28535155
15. The findings demonstrate that covalently-closed circular DNA levels are significantly lower in hepatocellular carcinoma tissues, and that the lower levels are likely to stem in part from up-regulation of APOBEC3B. PMID: 27310677
16. Data suggest that heat shock proteins, in particular Hsp90, stimulate APOBEC3-mediated DNA deamination activity toward hepatitis B viral DNA, suggesting a potential physiological role in mutagenesis/carcinogenesis and viral innate immunity; Hsp90 stimulates deamination activity of APOBEC3G, APOBEC3B, and APOBEC3C during co-expression in human liver HepG2 cells. PMID: 28637869
17. APOBEC3B mRNA levels are significantly higher in breast cancer metastases as compared to the corresponding estrogen receptor-positive primary tumors. PMID: 28141868
18. tumour-infiltrating immune cells may be an important feature of breast cancers arising in women with APOBEC3B germline deletion, and that this may be of particular interest in Asian women where the germline deletion is more common. PMID: 27233495
19. the APOBEC3B deletion polymorphism has neither a prognostic nor a predictive value for breast cancer patients. PMID: 27552096
20. Single-strand DNA-specific cytidine deaminase APOBEC3B (A3B) damages tRNA genes at 1000-fold higher efficiency than other non-tRNA genomic regions in Saccharomyces cerevisiae. A3B-induced lesions in tRNA genes were predominantly located on non-transcribed strand, while no transcriptional strand bias was observed in protein coding genes. It suggests transcription-dependent mechanism for A3B-induced tRNA gene hypermutation PMID: 28351647
21. These data link oncogene, loss of tumour suppressor gene and drug-induced replication stress with APOBEC3B activity, providing new insights into how cytidine deaminase-induced mutagenesis might be activated in tumourigenesis and limited therapeutically. PMID: 27634334
22. High APOBEC3B mRNA expression was related to the aggressive phenotypes of breast cancer, high frequency of TP53 mutation and poor prognosis, especially in ER-positive tumors. PMID: 27977754
23. crystal structures of human APOBEC3A and a chimera of human APOBEC3B and APOBEC3A bound to ssDNA at 3.1-A and 1.7-A resolution, respectively. PMID: 27991903
24. the classical NF-kappaB pathway is responsible for activation of A3B mRNA expression. PMID: 27577680
25. Collectively, these results indicate that human papillomavirus 16 E6 induces upregulation of APOBEC3B through increased levels of TEADs, highlighting the importance of the TEAD-APOBEC3B axis in carcinogenesis. PMID: 28077648
26. APOBEC3B mRNA expression was higher in OSCCs than in controls. APOBEC3B protein expression was high in both OSCCs and normal samples. PMID: 27818121
27. The expression of APOBEC3B in breast cancer was higher than in non-cancerous tissues and was related to the lymph node metastasis and nuclear grade. PMID: 26476745
28. results suggest that the APOBEC3A/3B deletion polymorphism is not significantly associated with cancer risk in our study population PMID: 27155849
29. This suggests that APOBEC3B deletion may attenuate innate cellular immunity against HIV-1 and thus confer the host persistence for HIV infection. PMID: 27522954
30. APOBEC3B expression was increased in some population of tumor cells of drug resistant cell lines. PMID: 27044816
31. APOBEC3A and APOBEC3B preferentially deaminate the lagging strand template during DNA replication. PMID: 26832400
32. Data indicate that SIVmac239 Vif protein efficiently degrades human DNA cytosine deaminase APOBEC3B protein (huA3B). PMID: 26544511
33. Data show that restriction factor APOBEC3G (A3G) is susceptible to degradation by the HIV-1 Vif protein, whereas restriction factor APOBEC3B (A3B) is resistant to Vif. PMID: 26668372
34. APOBEC3B is required for regulation of gene expression by ERalpha and acts by causing C-to-U deamination at ERalpha binding regions. PMID: 26411678
35. These results suggest that functional potential of APOBEC3B and APOBEC3C involved in cancer mutagenesis is associated with estrogen receptor status. PMID: 26682542
36. The APOBEC3B deletion polymorphism was found to be associated with HBV, HCV, TTV, and T. gondii co-infection in Indonesian HIV-infected individuals. PMID: 26305823
37. Germline variant and deletion polymorphism in APOBEC3B gene are not associated with breast cancer risk. PMID: 26320772
38. APOBEC3B expression was correlated with unfavorable prognosis in patients with gastric cancer. PMID: 26191203
39. APOBEC3B expression is an independent predictor of recurrence in patients with ccRCC, and the prognostic value is most prominent in those with low-risk disease. PMID: 26051357
40. report the first structures of the APOBEC3B catalytic domain in multiple crystal forms. These structures reveal a tightly closed active site conformation and suggest that substrate accessibility is regulated by adjacent flexible loops PMID: 26416889
41. APOBEC3B overexpression and Fhit-loss induced DNA damage are independent events that, when occurring together, result in a significantly increased frequency of APOBEC-induced mutations that drive cancer progression. PMID: 25401976
42. The N-terminal domain of A3B and at least three residues involved in DNA binding by the A3Bc catalytic domain contribute to the A3B attenuation of the double stranded DNA break phenotype. PMID: 26384561
43. Multiple experimental approaches combined demonstrate direct transcriptional upregulation of APOBEC3B by a signal transduction pathway involving the classical protein kinase C isoform protein kinase Ca and the noncanonical NF-kB transcription factor RELB. PMID: 26420215
44. APOBEC3A-mediated mutagenesis is much more frequent than APOBEC3B because APOBEC3A itself is highly proficient at generating DNA breaks. PMID: 26258849
45. This study defines and characterizes the catalytic domain of human APOBEC3B (A3B) enzyme. PMID: 26281709
46. DNA cytosine and methylcytosine deamination by APOBEC3B: enhancing methylcytosine deamination by engineering APOBEC3B. PMID: 26195824
47. Study provides evidence that APOBEC3B is overexpressed in chondrosarcoma tissues and cell lines and interferes with RUNX3 transcription. PMID: 25176183
48. High APOBEC3B is associated with the pathogenesis of primary effusion lymphoma. PMID: 25650088
49. results indicate that E6 activates the A3B promoter through the distal and proximal regions, and that ZNF384 is required for the proximal-region-mediated activation of A3B PMID: 25800874
50. These studies suggest a model in which high-risk human papillomavirus E6 causes derepression of APOBEC3B gene transcription, leading to a mutator phenotype that explains the observed cytosine mutation biases in papillomavirus positive cancers. PMID: 25538195

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HGNC: 17352

OMIM: 607110

KEGG: hsa:9582

STRING: 9606.ENSP00000327459

UniGene: Hs.226307