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Recombinant Human Probable serine carboxypeptidase CPVL (CPVL)

Recombinant Human Probable serine carboxypeptidase CPVL (CPVL)

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Code	CSB-EP875664HU
Abbreviation	Recombinant Human CPVL protein
MSDS	MSDS Datasheet
Size	$224
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Image	(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Product Details
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Target Background

Product Details

Purity

Greater than 90% as determined by SDS-PAGE.

Target Names

CPVL

Uniprot No.

Q9H3G5

Research Area

Cell Biology

Alternative Names

Carboxypeptidase; Carboxypeptidase vitellogenic like; carboxypeptidase WUG; CP-Mac carboxypeptidase; cpvl; CPVL_HUMAN; HVLP; MGC10029; Probable serine carboxypeptidase CPVL; Serine carboxypeptidase vitellogenic like; VCP like protein; VCP-like protein; Vitellogenic carboxypeptidase like protein; Vitellogenic carboxypeptidase-like protein; vitellogenic-like; VLP

Species

Homo sapiens (Human)

Source

E.coli

Expression Region

23-476aa

Target Protein Sequence

LFRSLYRSVSMPPKGDSGQPLFLTPYIEAGKIQKGRELSLVGPFPGLNMKSYAGFLTVNKTYNSNLFFWFFPAQIQPEDAPVVLWLQGGPGGSSMFGLFVEHGPYVVTSNMTLRDRDFPWTTTLSMLYIDNPVGTGFSFTDDTHGYAVNEDDVARDLYSALIQFFQIFPEYKNNDFYVTGESYAGKYVPAIAHLIHSLNPVREVKINLNGIAIGDGYSDPESIIGGYAEFLYQIGLLDEKQKKYFQKQCHECIEHIRKQNWFEAFEILDKLLDGDLTSDPSYFQNVTGCSNYYNFLRCTEPEDQLYYVKFLSLPEVRQAIHVGNQTFNDGTIVEKYLREDTVQSVKPWLTEIMNNYKVLIYNGQLDIIVAAALTERSLMGMDWKGSQEYKKAEKKVWKIFKSDSEVAGYIRQAGDFHQVIIRGGGHILPYDQPLRAFDMINRFIYGKGWDPYVG
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Mol. Weight

67.9kDa

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal 6xHis-SUMO-tagged

Form

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

3-7 business days

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet & COA

Please contact us to get it.

Description

The expression region of this recombinant Human CPVL covers amino acids 23-476. The calculated molecular weight for this CPVL protein is 67.9 kDa. This CPVL recombinant protein is manufactured in e.coli. The N-terminal 6xHis-SUMO tag was fused into the coding gene segment of CPVL, making it easier to detect and purify the CPVL recombinant protein in the later stages of expression and purification.

The human probable serine carboxypeptidase CPVL contains a serine carboxypeptidase-like domain and is expressed in various tissues, including the liver, pancreas, and kidney. CPVL is believed to possess serine carboxypeptidase-like activity and is involved in the post-translational modification of proteins. Some research suggests its potential association with conditions such as metabolic disorders and pancreatic cancer.

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Target Background

Function

May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.

Gene References into Functions

genetic association studies in a Chinese population with type 2 diabetes: An SNP in CPVL (rs39059) is associated with diabetic retinopathy in a Chinese population of type 2 diabetic patients. PMID: 21911749

Protein Families

Peptidase S10 family

Tissue Specificity

Expressed in macrophages but not in other leukocytes. Abundantly expressed in heart and kidney. Also expressed in spleen, leukocytes, and placenta.

Database Links

HGNC: 14399

OMIM: 609780

KEGG: hsa:54504

STRING: 9606.ENSP00000265394

UniGene: Hs.233389

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