Recombinant Human Prokineticin-2 (PROK2)

1. The results indicate that PK2 over-production perpetuates psoriatic symptoms by creating PK-2-IL-1 vicious loop. PK2 is a central player in psoriasis and a promising psoriasis-specific target. PMID: 27887936
2. Prokineticin-2 is correlated with various cardiometabolic risk factors. PMID: 26728949
3. Data suggest that prokineticins (PROK1 and PROK2) and prokineticin receptors (PROKR1 and PROKR2) act as main regulators of physiological functions of ovary, uterus, placenta, and testis. [REVIEW] PMID: 26574895
4. Suggest PROK2 as an angiogenic growth factor in colorectal cancer. PMID: 26317645
5. study found a novel mutation in PROK2 in two male siblings presenting normosmic congenital hypogonadotropic hypogonadism, in whom a mutation in the GNRHR gene had been previously described, suggesting the possibility of a digenic inheritance PMID: 25531638
6. PROK2 significantly increased in human fetal ovary across gestation. PMID: 26192875
7. EG-VEGF, BV8, and PROKR2 gene expression is approximately five, four, and two times higher in cystic fibrosis lungs compared with controls. PMID: 26047640
8. No abnormalities were found in the patient group for the PROKR2 and GNRH1genes. In addition, no genomic rearrangements were identified in the healthy control individuals for the described genes PMID: 24002956
9. PROK2 signaling in humans is not required for central circadian pacemaker function. PMID: 24423319
10. A novel role of BV8 in promoting oncogenesis intrinsic to malignant cells of myeloid origin. PMID: 23548897
11. We could not implicate the ligand PROK2 in congenital hypopituitarism and septo-optic dysplasia. PMID: 23386640
12. Three PROKR2 mutations previously described in Kallmann syndrome and one new PROK2 mutation were found in patients with isolated congenital anosmia. PMID: 23082007
13. Induction of Bv8 expression by granulocyte colony-stimulating factor in CD11b+Gr1+ cells: key role of Stat3 signaling. PMID: 22528488
14. Data suggest that elevated prokineticin 2 levels, as a consequence of gastrointestinal tract inflammation, induce visceral pain via prokineticin receptors. PMID: 22050240
15. Patients with this genetic form of Kallmann syndrome have been reported to have a possible increased prevalence of obesity and sleep disorders, which may be related to the role of PROK2 in food intake and circadian rhythms (Review) PMID: 20389090
16. Review. Role of prokineticins in inflammatory and contractile pathways at parturition in humans. PMID: 20172976
17. Male patients carrying biallelic mutations in PROK2 or PROKR2 have a less variable and on average a more severe reproductive phenotype than patients carrying monoallelic mutations in these genes. PMID: 20022991
18. Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus. PMID: 12024206
19. Bv8 and EG-VEGF, along with other factors such as VEGF-A, may maintain the integrity and also regulate proliferation of the blood vessels in the testis PMID: 12604792
20. Paracrine role for the PKs and their receptors in endometrial vascular function. PMID: 15126578
21. potentially modulates growth, survival, and function of cells of the innate and adaptive immune systems, possibly through autocrine or paracrine signaling mechanisms PMID: 15548611
22. study demonstrated that prokineticin 1 and 2 and their receptors are expressed in human prostate and that their levels increased with prostate malignancy PMID: 16763065
23. These findings reveal that insufficient prokineticin-signaling through PROKR2 leads to abnormal development of the olfactory system and reproductive axis in man. PMID: 17054399
24. Homozygous loss-of-function PROK2 mutations cause both Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism PMID: 17959774
25. The identification of PROK2 biallelic mutations, that is, a missense mutation, p.R73C, and a frameshift mutation, c.163delA, in two out of 273 patients presenting as sporadic cases, is reported. PMID: 18285834
26. PK2/Bv8 expression decreases as the liver evolves towards cancer and does not correlate with HCC angiogenesis PMID: 18300343
27. Loss-of-function mutations in PROK2 and PROKR2 underlie both Kallmann syndrome (KS) and normosmic idiopathic hypogonadotropic hypogonadism (IHH). PMID: 18559922
28. Loss-of-function mutations in the genes encoding prokineticin-2 or prokineticin receptor-2 cause autosomal recessive Kallmann syndrome. PMID: 18682503
29. no mutations found in Kallmann syndrome PMID: 18723471
30. Bv8 expression is regulated by several cytokines in a cell type-specific fashion PMID: 19336519

Show More

Hide All

HGNC: 18455

OMIM: 607002

KEGG: hsa:60675

STRING: 9606.ENSP00000295619

UniGene: Hs.528665