This PCSK6 protein is a semi-custom product. There are 5 expression system options: Yeast, E. coli, In Vivo Biotinylation in E. coli, Baculovirus, and Mammalian cell. Your requirements will be given top priority in determining the protein tags. For proteins within 800 aa, risk-free custom service is guaranteed. It means you will not be charged if the protein cannot be delivered.
PCSK6 (proprotein convertase subtilisin/kexin type 6) is a protease enzyme important for various biological processes. Research has shown that PCSK6 is associated with handedness in individuals with dyslexia [1]. Additionally, PCSK6 has been identified as a key protease in controlling smooth muscle cell function in vascular remodeling [2]. It induces smooth muscle cell migration in response to PDGFB and modulates contractile markers and MMP14 activation [2]. Moreover, PCSK6 has been linked to atherosclerosis, with increased expression observed in symptomatic lesions, particularly in smooth muscle α-actin positive cells and the extracellular matrix of the fibrous cap [3].
Furthermore, PCSK6 is involved in various diseases and conditions. It has been associated with glioma invasion as a candidate gene [4]. In cardiovascular biology, PCSK6 is expressed in major organs and cleaves a wide range of molecules, including growth factors and signaling molecules [5]. In breast cancer, PCSK6 activates pathways such as extracellular signal-regulated kinase 1/2 and Wnt family member 3A, promoting cancer cell proliferation, migration, and invasion [6]. Furthermore, PCSK6 is involved in the activation of natriuretic peptides, regulating cardiovascular and renal function [7].
References:
[1] T. Scerri, W. Brandler, S. Paracchini, A. Morris, S. Ring, A. Richardsonet al., Pcsk6 is associated with handedness in individuals with dyslexia, Human Molecular Genetics, vol. 20, no. 3, p. 608-614, 2010. https://doi.org/10.1093/hmg/ddq475
[2] U. Rykaczewska, B. Suur, S. Röhl, A. Razuvaev, M. Lengquist, M. Sabater‐Llealet al., Pcsk6 is a key protease in the control of smooth muscle cell function in vascular remodeling, Circulation Research, vol. 126, no. 5, p. 571-585, 2020. https://doi.org/10.1161/circresaha.119.316063
[3] L. Perisic, E. Hedin, A. Razuvaev, M. Lengquist, C. Österholm, L. Folkersenet al., Profiling of atherosclerotic lesions by gene and tissue microarrays reveals pcsk6 as a novel protease in unstable carotid atherosclerosis, Arteriosclerosis Thrombosis and Vascular Biology, vol. 33, no. 10, p. 2432-2443, 2013. https://doi.org/10.1161/atvbaha.113.301743
[4] S. Delic, N. Lottmann, K. Jetschke, G. Reifenberger, & M. Riemenschneider, Identification and functional validation of cdh11, pcsk6 and sh3gl3 as novel glioma invasion‐associated candidate genes, Neuropathology and Applied Neurobiology, vol. 38, no. 2, p. 201-212, 2012. https://doi.org/10.1111/j.1365-2990.2011.01207.x
[5] Q. Wu and S. Chen, Proprotein convertase subtilisin/kexin 6 in cardiovascular biology and disease, International Journal of Molecular Sciences, vol. 23, no. 21, p. 13429, 2022. https://doi.org/10.3390/ijms232113429
[6] P. Wang, F. Wang, L. Wang, & J. Pan, Proprotein convertase subtilisin/kexin type 6 activates the extracellular signal‑regulated kinase 1/2 and wnt family member 3a pathways and promotes in�vitro proliferation, migration and invasion of breast cancer mda‑mb‑231 cells, Oncology Letters, 2018. https://doi.org/10.3892/ol.2018.8654
[7] E. Petra, T. He, V. Lygirou, A. Latosinska, H. Mischak, A. Vlahouet al., Urine peptidome analysis in cardiorenal syndrome reflects molecular processes, Scientific Reports, vol. 11, no. 1, 2021. https://doi.org/10.1038/s41598-021-95695-z
