Recombinant Human Protein FAM19A4 (FAM19A4)

Code CSB-YP836253HU
MSDS
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Source Yeast
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Code CSB-EP836253HU
MSDS
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Source E.coli
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Code CSB-EP836253HU-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP836253HU
MSDS
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Source Baculovirus
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Code CSB-MP836253HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
FAM19A4
Uniprot No.
Alternative Names
TAFA4; FAM19A4; Chemokine-like protein TAFA-4
Species
Homo sapiens (Human)
Expression Region
36-140
Target Protein Sequence
SQHLR GHAGHHQIKQ GTCEVVAVHR CCNKNRIEER SQTVKCSCFP GQVAGTTRAQ PSCVEASIVI QKWWCHMNPC LEGEDCKVLP DYSGWSCSSG NKVKTTKVTR
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Modulates injury-induced and chemical pain hypersensitivity. Ligand of FPR1, can chemoattract macrophages, promote phagocytosis and increase ROS release.
Gene References into Functions
  1. Hypermethylation of FAM19A4/miR124-2 in the self-sample was tested in a quantitative methylation specific PCR and compared between lesions caused by HPV16/18 and other hrHPV genotypes. There were no differences in the percentages of positive FAM19A4/miR124-2 methylation assays between lesions caused by HPV16/18 (73.8% in CIN3+) or other hrHPV genotypes (66.7% in CIN3+) (p=0.538). PMID: 30219239
  2. With a similarly good clinical performance in both sample types, combined FAM19A4 methylation analysis and HPV16/18 genotyping provides a feasible triage strategy for hrHPV-positive women, with direct applicability on self-samples PMID: 27415009
  3. FAM19A4/mir124-2 methylation analysis performs equally well in HPV-positive lavage- and brush self-samples to identify women with CIN3+. In combination with HPV16/18 genotyping, significantly higher CIN3+ sensitivities are obtained, at decreased specificity. PMID: 26921784
  4. FAM19A4 is a novel ligand of formyl peptide receptor 1. PMID: 25109685
  5. among high risk HPV-positive women from an outpatient population aged >/= 30 years, methylation analysis of FAM19A4 is an attractive marker for the identification of women with high-grade cervical intraepithelial neoplasia and cervical cancer PMID: 26317579
  6. High methylation of FAM19A4 is associated with cervical carcinomas. PMID: 25281488

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Subcellular Location
Secreted.
Protein Families
FAM19/TAFA family
Tissue Specificity
Expressed in brain. Expressed in LPS-stimulated monocytes and macrophages, especially in polarized M1.
Database Links

HGNC: 21591

OMIM: 617498

KEGG: hsa:151647

STRING: 9606.ENSP00000295569

UniGene: Hs.187873

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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