Recombinant Human Protein phosphatase 1 regulatory subunit 1C (PPP1R1C)

Code CSB-YP819897HU
MSDS
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Source Yeast
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Code CSB-EP819897HU
MSDS
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Source E.coli
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Code CSB-EP819897HU-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP819897HU
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP819897HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
PPP1R1C
Uniprot No.
Alternative Names
PPP1R1C; Protein phosphatase 1 regulatory subunit 1C; Inhibitor-5 of protein phosphatase 1; IPP5
Species
Homo sapiens (Human)
Expression Region
1-109
Target Protein Sequence
MEPNSPKKIQ FAVPVFQSQI APEAAEQIRK RRPTPASLVI LNEHNPPEID DKRGPNTQGE LQNASPKQRK QSVYTPPTIK GVKHLKGQNE SAFPEEEEGT NEREEQRDH
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
May increase cell susceptibility to TNF-induced apoptosis.
Gene References into Functions
  1. The data demonstrate a novel role for 8-60hIPP5(m) in the control of G2/M cell cycle progression, a process that involves the activation of ATM/p53/p21cip1/waf1/Cdc2/ cyclin B1 pathways. PMID: 24935604
  2. IPP5 mutations are associated with response to paclitaxel in cervical cancer. PMID: 25339026
  3. The effect of IPP5 on tumor growth and the underlying molecular mechanisms were investigated by overexpression of IPP5 in HeLa cells, a human cervical carcinoma cell line. PMID: 22939397
  4. Overexpression of active mutant IPP5 inhibited anchorage-dependent growth and induced apoptosis in HeLa cells, which may be attributed to the up-regulation of p21, p53 and Bcl-2-antagonist/killer, and down-regulation of Bcl-2 and Bcl-X(L). PMID: 19874272
Subcellular Location
Cytoplasm.
Protein Families
Protein phosphatase inhibitor 1 family
Database Links

HGNC: 14940

OMIM: 613240

KEGG: hsa:151242

STRING: 9606.ENSP00000386359

UniGene: Hs.10941

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