Recombinant Human Protein scribble homolog (SCRIB), partial

1. Perturbation of hepatocellular polarity due to overexpression and cytoplasmic enrichment of Scrib supports tumor initiation and hepatocellular carcinoma cell dissemination through specific molecular mechanisms PMID: 29152770
2. Data suggest that millisecond dynamic changes in PDZ1 domain conformation are responsible for higher affinity of scribble PDZ1 for phosphorylated ligands; oligopeptide fragments of RPS6KA2 and MCC were used as ligands in these nuclear magnetic resonance chemical shift experiments. (RPS6KA2 = ribosomal protein S6 kinase 2; MCC = mutated in colorectal cancer protein) PMID: 29144123
3. Scrib inhibits liver cancer cell proliferation by suppressing the expression of three oncogenes, Yap1, c-Myc and cyclin D1, thereby functioning as a tumor suppressor in liver cancer. PMID: 28460446
4. In this study the authors show that human Scrib expression is required for maintaining high levels of human papillomavirus type 18 E6 protein in HeLa cells. PMID: 29074188
5. Data suggest that Scribble PDZ-domain-1 and PDZ-domain-3 are major domains that interact with beta-PIX and exhibit distinct binding hierarchy in interactions between individual Scribble PDZ domains and beta-PIX. (Scribble = scribbled planar cell polarity protein; beta-PIX = Rho guanine nucleotide exchange factor 7) PMID: 29061852
6. inhibiting acyl thioesterase 2 restores balance to the Scrib palmitoylation cycle, promoting membrane re-localization and growth attenuation PMID: 28065656
7. sequencing analysis of SCRIB1 in 473 NTD patients led to the identification of 5 rare heterozygous missense mutations that were predicted to be pathogenic. Two of these mutations, p.Gly263Ser and p.Gln808His, and 2 mouse NTD mutations, p.Ile285Lys and p.Glu814Gly, affected Scrib1 membrane localization and its modulating role of Par-3 and Vangl1 localization. PMID: 28369449
8. a new function for Scribble in Rho regulation that entails positioning of DLC3 GAP activity at cell junctions in polarized epithelial cells, is reported. PMID: 27505894
9. Low Scribble expression in the primary breast tumor was correlated to prognosis in estrogen receptor-positive breast cancer patients. PMID: 27562784
10. Suggest a role for Plexin-B1 as a ligand and Sema4A as a receptor and characterize a reverse signaling pathway downstream of Sema4A regulating cell migration via Scrib. PMID: 28007914
11. SCRIB uncouples reactive oxygen species-dependent bacterial killing activity from M1 polarization and inflammatory functions of macrophages PMID: 27694890
12. The Palmitoylation-deficient mutants of SCRIB were mislocalized, leading to disruption of cell polarity and loss of their tumor-suppressive activities to oncogenic YAP, MAPK and PI3K/AKT pathways. PMID: 27380321
13. Data show hepatitis C virus (HCV) nonstructural protein 4B (NS4B) PDZ-binding motif (PBM) promotes the colony formation of hepatoma cells by degrading human Scribble protein. PMID: 27315218
14. the inclusion/exclusion of specific SCRIB exons is a mechanistic hallmark of breast cancer, which could potentially be exploited to develop more efficient diagnostics and therapies. PMID: 27428426
15. loss of Scribble-induced HuR translocation mediates the accumulation of Snail via activation of the p38 MAPK pathway. PMID: 26527679
16. The two PDZ domains within the PDZ34 tandem of Scribble, a cell polarity regulator, tightly pack in a 'front-to-back' mode to form a compact supramodule. PMID: 25734361
17. We show that loss of Scrib and activated oncogenic KRas cooperate in vivo, resulting in more aggressive lung tumors PMID: 24276238
18. High levels of mislocalized SCRIB functions as a neomorph to promote mammary tumorigenesis. PMID: 24662921
19. miR-296-5p/SCRIB axis plays a role in breast carcinogenesis PMID: 24527800
20. This study demonstrated that rare deleterious mutations of SCRIB may contribute to the multifactorial risk for human spina bifida. PMID: 23922697
21. These data suggests a novel role for Scribble in positively regulating tight junction assembly through transcriptional regulation of an epithelial-to-mesenchymal signaling program. PMID: 23813956
22. SHOC2 and MRAS form a complex with SCRIB. PMID: 24211266
23. Although the Scribble P305L mislocalization mutant can no longer suppress Ras-MAPK-induced invasion or epithelial to mesenchymal transition phenotypes, mislocalized Scribble can still suppress anchorage-independent cell growth. PMID: 23774808
24. CD74-dependent deregulation of the tumor suppressor Scribble in human epithelial and breast cancer cells. PMID: 23730214
25. results demonstrate that hScrib acts as a scaffold to integrate the control of the PP1gamma and ERK signaling pathways and explains how disruption of hScrib localisation can contribute towards the development of human malignancy PMID: 23359326
26. During anoikis, hScrib and hDlg1 have distinct and opposing functions in human keratinocytes. PMID: 22792261
27. NOS1AP colocalizes with both SCRIB and VANGL1 along cellular protrusions in metastatic breast cancer cells, but does not colocalize with either SCRIB or VANGL1 at cell junctions in normal breast cells PMID: 22179838
28. Missense variants in SCRIB may represent a cause of craniorachischisis in humans, as in mice, with defective planar cell polarity protein trafficking to the plasma membrane a likely pathogenic mechanism. PMID: 22095531
29. SCRIB deregulation strongly correlated with poor survival in prostate cancer PMID: 21965329
30. These findings indicate that binding of NS1 to Scribble and Dlg1 functions to disrupt the cellular tight junction and that this effect likely contributes to the severe disease associated with highly pathogenic H5N1 influenza A viruses. PMID: 21849460
31. These data uncover a previously unrecognized exploitation of Scrib for aberrant tumor cell motility and invasion, thus potentially contributing to disease progression in humans. PMID: 21549346
32. genetic variability in the SCRIB polarity gene does not contribute to breast cancer development PMID: 20936341
33. HPV16 E6 association with PDZ domain-containing proteins, MAGI1, Dlg1 or Scrib, stabilized the levels of E6. PMID: 21489588
34. single nucleotide polymorphisms in scrib is not associated with breast cancer. PMID: 21086040
35. one function of the avian NS1 ESEV PBM sequence is to reduce apoptosis during infection through disruption of Scribble's proapoptotic function PMID: 20702615
36. hScrib is involved in the development of endometrial cancer. PMID: 20939435
37. HMGB1 release, as well as its redox state, thus links autophagy and apoptosis, representing a suitable target when coupled with conventional tumor treatments PMID: 20622900
38. Scribble is an important regulator of tight junctions functions and plasticity in the intestinal epithelium. PMID: 19959811
39. hScrib is a functional homologue of DmScrib and therefore predict an important role for hScrib in the suppression of mammalian tumorigenesis PMID: 14681682
40. Degradation by human papilloma virus E6 may cause progressive decrease of hScrib expression during disease progression from low-grade squamous intraepithelial lesions (SIL) to high-grade SIL PMID: 14710229
41. May act as a tumor suppressor PMID: 15261375
42. LPP and Scrib proteins localize in cell-cell contacts. This interaction links Scrib to a communication pathway between cell-cell contacts and the nucleus, and implicates LPP in Scrib-associated functions PMID: 15649318
43. hScrib directly binds to the G protein-coupled thyroid stimulating hormone receptor (TSHR), inhibits basal receptor endocytosis and promotes recycling, and thus TSHR signalling, at the cell membrane. PMID: 15775968
44. data establishs a potential link between the E-cadherin and hScrib tumor suppressors PMID: 15806148
45. The direct interaction between hScrib and ZO-2, a junction-associated protein, was reported. PMID: 15975580
46. mapped the binding site of E6 on hScrib and shown that the interaction of E6 with hScrib is distinct from its interactions with other PDZ domain-containing targets PMID: 16103886
47. interacts with TRIP6; binding between two of zyxin's family members and Scrib links Scrib to a communication pathway between cell-cell contacts and the nucleus, and implicates these zyxin family members in Scrib-associated functions PMID: 16137684
48. These results suggest that Scrib stabilizes the coupling between E-cadherin and the catenins and are consistent with the idea that mammalian Scrib could behave as a tumor suppressor by regulating epithelial cell adhesion and migration. PMID: 16344308
49. E6AP is extensively involved in the ubiquitin-mediated degradation of SCRIB (an HPV E6-dependent substrate) as a cellular E3 ubiquitin-protein ligase. PMID: 16482544
50. Knockdown of hScrib expression by RNAi disrupts localization of adenomatous polyposis coli(APC) at the adherens junction. These data suggest hScrib may participate in the hDlg-APC complex through PDZ domains and regulate cell cycle and neural function PMID: 16611247

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HGNC: 30377

OMIM: 182940

KEGG: hsa:23513

STRING: 9606.ENSP00000349486

UniGene: Hs.436329