Recombinant Human RAS guanyl-releasing protein 1 (RASGRP1), partial

1. Histidine 212 is located at the fulcrum of these conformational changes, and structural features in its vicinity are consistent with its function as a pH-dependent switch. PMID: 28952923
2. The rs7170151 in RASGRP1 showed novel associations in IgA nephropathy. PMID: 27804980
3. The marked differences between RasGRP3 and RasGRP1 in membrane interaction necessarily will contribute to their different behavior in cells. PMID: 28912101
4. Cytokines IL-2/7/9 stimulation activates PI3K/Akt pathways downstream of Ras in RasGRP1 T-cell acute lymphoblastic leukemia (T-ALL). PMID: 26549032
5. results demonstrate the critical role of CalDAG-GEFI in rapid alphaIIbbeta3 activation of human platelets. PMID: 27663674
6. Low-level expression of CD-GEFI impairs platelet activation, leading to protection from thrombosis, but not to marked bleeding in mice. PMID: 27417588
7. This study shows that deficiency in RASGRP1 results in a previously unknown primary immunodeficiency disease, and that RASGRP1 plays role in immune cell signaling and function in T cells, B cells and NK cells. It also identifies a previously unknown role for RASGRP1 in the dynamic regulation of the cytoskeleton, and identify lenalidomide as a potpotential treatment option for this immunodeficiency. PMID: 27776107
8. This study aimed to replicate and verify the association of RASGRP1 tag single-nucleotide polymorphisms with T2D in a Chinese Han population. PMID: 26076219
9. present a crystal structure of a fragment of RasGRP1 in which the Ras-binding site is blocked by an interdomain linker and the membrane-interaction surface of RasGRP1 is hidden within a dimerization interface PMID: 23908768
10. A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans. PMID: 22961080
11. This is the first study aimed at evaluating CalDAG-GEFI gene sequences in people with mucocutaneous bleeding of unknown cause. PMID: 21815871
12. PAQR10 and PAQR11 are able to interact with RasGRP1, a guanine nucleotide exchange protein of Ras, and increase Golgi localization of RasGRP1. The C1 domain of RasGRP1 is both necessary and sufficient for the interaction of RasGRP1 with PAQR10/PAQR11. PMID: 21968647
13. cooperation between aberrant expression of RasGRP1, a strong activator of Ras, and secondary gain-of-function mutations of NOTCH1 have an important role in T-cell leukemogenesis PMID: 22116551
14. remission in systemic lupus erythematosus activity associated with decreased RasGRP-1 expression in lymphocytes PMID: 21976405
15. Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRalpha gene expression. PMID: 21966541
16. SDF-1 treatment of T cells induced the formation of a novel molecular signaling complex containing RasGRP1, Galphai2, and ZAP-70. PMID: 21856938
17. Data show that the RASGRP1/APTX gene expression ratio was higher in the responder while the AKAP13 expression was higher in the non-responders. PMID: 19960345
18. in response to Src-dependent activation of phospholipase Cgamma1, the Ras guanine nucleotide exchange factor RasGRP1 translocated to the Golgi where it activated Ras PMID: 12845332
19. RasGRP binds to three DAG molecular species, but only DAG-AA and DAG-DHA participate in the modulation of RasGRP-mediated activation of MAP kinases in Jurkat T cells PMID: 14583629
20. RasGRP1 transgene conferred pre-TCR-independent survival and proliferation of immature thymocytes, suggesting that deregulated expression of RasGRP1 promotes lymphomagenesis by expanding the pool of thymocytes which are susceptible to transformation. PMID: 15829980
21. RasGRP1-/- mast cells had markedly reduced degranulation and cytokine production. PMID: 17190838
22. The unusual RasGRP-SOS interplay results in sensitive and robust Ras activation that cannot be achieved with either activator alone. PMID: 17283063
23. CalDAG-GEFI as a critical regulator of inside-out integrin activation in human T lymphocytes, neutrophils, and platelets. PMID: 17576779
24. These results suggest that SKAP55 modulates signal transduction from the T cell antigen receptor to Ras by binding to RasGRP1. PMID: 17658605
25. Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 mediated human T-cell adhesion. PMID: 17702895
26. identify 13 new splice variants of the human RasGRP1 gene PMID: 17878389
27. Stimulation of human mast cells by activated T cells leads to N-Ras activation through Ras guanine nucleotide releasing protein 1. PMID: 18760455
28. Studied RASGRP1, found 1 locus, mapping to a linkage disequilibrium (LD) block at chr15q14, reached statistical significance by combining results from two markers. PMID: 19465406

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HGNC: 9878

OMIM: 152700

KEGG: hsa:10125

STRING: 9606.ENSP00000310244

UniGene: Hs.591127