Recombinant Human RNA-binding protein 5 (RBM5), partial

1. RNA binding motif protein 10 (RBM10) negatively regulates its own mRNA and protein expression and that of RNA binding motif protein 5 (RBM5) by promoting alternative splicing-coupled nonsense-mediated mRNA decay (AS-NMD). PMID: 28586478
2. results provide evidence that RBM10 expression, in RBM5-null tumors, may contribute to tumor growth and metastasis. Measurement of both RBM10 and RBM5 expression in clinical samples may therefore hold prognostic and/or potentially predictive value PMID: 28662214
3. the mechanism of action of RBM5-AS1 in the WNT pathway via physical interactions with beta-catenin, helping organize transcriptional complexes that sustain colon cancer-initiating cells function. PMID: 27520449
4. Low RBM5 expression was significantly associated with gliomas. PMID: 28061901
5. RNA-binding motif 5 silencing reduced the messenger RNA and protein expression of the p53 target gene p21. Our results suggest that RNA-binding motif 5 downregulation is involved in gastric cancer progression and that RNA-binding motif 5 behaves as a tumor suppressor gene in gastric cancer PMID: 28347247
6. Results show that RBM5 is downregulated in smoke induced tumor; its overexpression inhibits tumor growth through cell cycle arrest and induction of apoptosis suggesting the importance of RBM5 in the pathogenesis of smoking-related cancer. PMID: 26782095
7. ICG-001 had no apparent effect on the RBM5 levels. PMID: 25738917
8. RBM5 knockdown in human neuronal cells decreases caspase activation by staurosporine. PMID: 25586139
9. Loss of RBM5 expression is associated with lung adenocarcinoma. PMID: 23721095
10. expression of RBM5 protein was significantly decreased in cancerous prostatic tissues compared to the normal tissues PMID: 23158838
11. RBM5 can inhibit the growth of lung cancer cells and induce apoptosis both in vitro and in vivo. PMID: 22866867
12. Expression of RBM5 mRNA and protein was negatively correlated with expression of EGFR and KRAS mRNA and protein in NSCLC tissues. PMID: 22537942
13. RBM5 promotes exon 4 skipping of AID pre-mRNA by competing with the binding of U2AF65 to the polypyrimidine tract. PMID: 23017209
14. RBM5 may serve as a biomarker with the ability to predict a response to cisplatin PMID: 22609235
15. The results suggest that RBM5 expression is not directly regulated by EGFR in non-smoker related lung adenocarinomas. PMID: 22882865
16. NMR data analysis of RBM5 RRM2 reveals several features of protein-RNA interfaces. The most striking observation is the presence of two preferred target RNA sequences, the sequences [5'-(CUCUUC)-3'] and [5'-(GAGAAG)-3']. PMID: 22839758
17. Data suggest that G-patch domain of RBM5 is indispensable for its ability to interact with DHX15; RBM5 stimulates helicase activity of DHX15 in a G-patch domain-dependent manner. PMID: 22569250
18. alters expression of genes involved in metastasis PMID: 20338664
19. p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5. PMID: 20309933
20. Over-expression of the splice variant LUCA15 shortened the cell cycle and inhibited CD95-mediated apoptosis in CEM-C7 T-cells. PMID: 12581154
21. LUCA-15/RMB5 sensitises Jurkat cells to apoptosis initiated by anti-Fas antibody, TNF-alpha, or TRAIL. PMID: 15192330
22. Results provide the first evidence of an apoptotic modulatory role for LUCA-15 in MCF-7 breast carcinoma cell line, which is a non-T cell line. PMID: 15338470
23. Results suggest that LUCA-15 plays a central role in regulating cell fate consistent with its tumor suppressor activity. PMID: 16546166
24. H37 was transfected into A549 non-small cell lung cancer cells. A549/H37 cells show significant growth inhibition compared with the vector controls by in vitro and in vivo cell proliferation assays. PMID: 16585163
25. Results suggest that reversible phosphorylation of RBM5 is a mechanism capable of regulating RBM5 participation in modulating apoptosis, and perhaps tumour suppression. PMID: 16927403
26. analysis of Hedgehog modulator properties after functional coupling of Smoothened to G15 PMID: 16945339
27. specific allele types at C1138T and C2185T single nucleotide polymorphisms positions are correlated with different histological subtypes of non-small cell lung cancer PMID: 17606309
28. In breast tumour tissue, chimeric expression was associated with elevated levels of RBM5 mRNA, and increased tumour size. PMID: 17908320
29. suggest some of the possible, further- alternative means of the H37/RMB5 gene expression loss in tumor, including defects in transcription and post-transcriptional/translational modifications as well as mechanisms related to haploinsufficiency PMID: 18038152
30. RBM5 binds to casp-2 pre-mRNA at a U/C-rich sequence immediately upstream of the previously identified In100 splicing repressor element PMID: 18840686
31. RBM5 inhibits the transition between prespliceosomal complexes assembled around exon 6 to mature spliceosomes assembled on the flanking introns and promotes sequence-specific pairing of the distal splice sites. PMID: 18851835
32. LUST is a novel, functional, non-coding RNA that plays a role in determining the apoptotic fate of a cell by regulating the expression of RBM5 splice variants. PMID: 19559772

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HGNC: 9902

OMIM: 606884

KEGG: hsa:10181

STRING: 9606.ENSP00000343054

UniGene: Hs.439480