Recombinant Human Rac GTPase-activating protein 1 (RACGAP1)

1. RACGAP1 promotes proliferation of hepatocellular carcinoma cells by reducing activation of the Hippo and YAP pathways and promoting cytokinesis in coordination with nuclear basket protein, TPR. PMID: 30009820
2. The rs615382 variant disrupts the recombination signal binding protein with immunoglobulin kappa J binding site in Rac GTPase activating protein 1. Disruption of notch 1 mediated-repression of RACGAP1 may contribute to Prostate Cancer in African Americans. PMID: 29695400
3. Study showed that a subset of epithelial ovarian cancer (EOC) patients have RacGAP1 overexpression which is associated with advanced tumor stages and poor clinical outcomes. Also, RacGAP1 can positively regulate the activation of RhoA and Erk proteins, thus up-enhance the migration and invasion process of EOC. PMID: 29095547
4. Data show that comparing with Ki-67 and TOP2A, RacGAP1 allowed for a clearer prognostic statement. PMID: 27259241
5. RACGAP1 promotes the metastatic phenotype in uterine carcinosarcoma via a STAT3/survivin signaling pathway. PMID: 27121792
6. High RACGAP1 expression is associated with Basal-like Breast Cancers. PMID: 27216196
7. This study showed that the overexpressions of Ki67, RacGAP1, and TOP2a affect the prognosis of female breast cancer patients adversely PMID: 27284123
8. Data confirmed a strong correlation of AURKA and Wnt-modulator RACGAP1 gene expression both in the gastric tumor, the tumor-adjacent and the tumor-distant mucosa. PMID: 26778597
9. RacGAP1 Is a Novel Downstream Effector of E2F7-Dependent Resistance to Doxorubicin and Is Prognostic for Overall Survival in Squamous Cell Carcinoma PMID: 26018753
10. RACGAP1 expression levels in the nucleus and cytoplasm, determined by immunohistochemical staining, predict opposite clinical outcomes and that both could be independent prognostic markers for colorectal cancer. PMID: 26508373
11. central spindle assembly and 2 Plk1-dependent phosphorylations are required to establish efficient binding of the Ect2 BRCT in early cytokinesis. PMID: 25486482
12. RacGAP1 expression at the invasive front in gastric cancer was significantly correlated with factors reflecting tumor progression and poor prognosis.RACGAP1 gene expression in diffuse type gastric cancer was elevated. PMID: 24615626
13. RacGAP1 mediated endothelial barrier function loss and melanoma transmigration in a focal adhesion-dependent manner.RacGAP1 activation mediates focal adhesion assembly and actin stress fiber formation. PMID: 25475728
14. High RacGAP1 expression was an independent predictive marker for lymph node metastasis, recurrence and poor prognosis in colorectal cancer patients. PMID: 25568185
15. HCV viral protein NS5B polymerase activity was significantly reduced by silencing RacGAP1 and, vice versa, was increased by overexpression of RacGAP1 in a cell-based reporter assay. PMID: 25305482
16. We show that some are new substrates of the anaphase-promoting complex/cyclosome and validate KIFC1 and RacGAP1/Cyk4 as two such targets involved respectively in timely mitotic spindle disassembly and cell spreading PMID: 24857844
17. MgcRacGAP colocalizes with CGN and CGNL1 at TJs and forms a complex and interacts directly in vitro with CGN and CGNL1. PMID: 24807907
18. High expression of RACGAP1 is associated with meningiomas. PMID: 23525949
19. APC(CDH1) targets MgcRacGAP for destruction in the late M phase. PMID: 23696789
20. The crystal structure of the GAP domain of MgcRacGAP has been determined at a resolution of 1.9A; MgcRacGAP (residues 348-546) exists as a monomer in solution. PMID: 23665020
21. In untreated patients, Ki67, TOP2A, and RacGAP1 are significant and independent prognostic markers. PMID: 23135572
22. High RACGAP1 mRNA expression (above the median) was associated with poor disease-free survival and overall survival in high risk early breast cancer PMID: 23096218
23. MKlp1-CYK4 centralspindlin complex is a guanosine triphosphatase-activating protein (GAP) for Rac1 and not RhoA. PMID: 22945935
24. several Rho family small GTPases activate PI3K by an indirect cooperative positive feedback that required a combination of Rac, CDC42, and RhoG small GTPase activities PMID: 22683270
25. the level of RACGAP1 expression is sufficient to predict the early recurrence of HCC. PMID: 21825042
26. The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding PMID: 11937491
27. This enzyme is down-regulated by estradiol. PMID: 12493759
28. Expression of a GTPase-activating protein (GAP)-deficient mutant (R386A) of MgcRacGAP induces abnormal cortical activity during cytokinesis in U2OS cells. Multiple large blebs were observed in cells expressing MgcRacGAP R386A. PMID: 14729465
29. data reveal an important role for MgcRacGAP in STAT3 activation, and demonstrate that MgcRacGAP regulates IL-6-induced cellular differentiation in which STAT3 plays a pivotal role PMID: 15284113
30. MgcRacGAP regulates the activation and function of Cdc42 in mitosis. PMID: 15642749
31. H-Ras-specific activation of Rac-MKK3/6-p38 pathway has a role in invasion and migration of breast epithelial cells PMID: 15677464
32. intracellular Ca2+ is mobilized by sphingosine 1 phosphate and mediates rac activation and adherens junction assembly in endothelial cells PMID: 15728185
33. beta 2 chimerin has a role in rac-GAP-dependent inhibition of breast cancer cell proliferation PMID: 15863513
34. activation of Vav1-Rac signaling pathway by CXCL12 represents an important inside-out event controlling efficient up-regulation of alpha4beta1-dependent T lymphocyte adhesion PMID: 15872091
35. Cdk1 inactivation is sufficient to activate a signaling pathway leading to cytokinesis, which emanates from mitotic spindles and is regulated by ECT2, MgcRacGAP, and RhoA PMID: 16118207
36. MgcRacGAP controls the initiation of cytokinesis by regulating ECT2, which in turn induces the assembly of the contractile ring and triggers the ingression of the cleavage furrow PMID: 16129829
37. This study defines a cellular mechanism that links centralspindlin to Cep55, which, in turn, controls the midbody structure and membrane fusion at the terminal stage of cytokinesis. PMID: 16790497
38. These findings demonstrate that HIF-1alpha function is negatively affected by its interaction with MgcRacGAP. PMID: 17982282
39. report here that (i) MgcRacGAP is phosphorylated by Aurora B and Cdk1, (ii) PP2A dephosphorylates Aurora B and Cdk1 phosphorylated sites and (iii) inhibition of PP2A abrogates MgcRacGAP/Ect2 interaction PMID: 18201571
40. Study demonstrates that FIP3 and ECT2 form mutually exclusive complexes with Cyk-4 and that dissociation of ECT2 from the mid-body at late telophase may be required for the recruitment of FIP3 and recycling endosomes to the cleavage furrow. PMID: 18511905
41. study reports that mitotic complex genes Ect2, RacGAP, and MKLP1 are coordinately induced in S phase in proliferating T lymphocytes as well as in epithelial cells, depending upon activity of the CUX1 and E2F1 transcription factors PMID: 19015243
42. MKLP1 interacts with CYK4, a GTPase activating protein for the Rho GTPase, to form the centralspindlin complex. Centralspindlin is a key regulator of Rho function and microtubule organisation during cytokinesis, and is essential for cell division. PMID: 11782313

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HGNC: 9804

OMIM: 604980

KEGG: hsa:29127

STRING: 9606.ENSP00000309871

UniGene: Hs.505469