Recombinant Human Receptor-type tyrosine-protein phosphatase gamma (PTPRG), partial

1. miR-19b inhibits PTPRG expression to promote tumorigenesis in human breast cancer PMID: 27602768
2. Co-localization experiments performed with both anti-PTPRG antibodies identified the presence of isoforms and confirmed protein downregulation at diagnosis in the Philadelphia-positive myeloid lineage (including CD34+/CD38bright/dim cells). PMID: 28637510
3. family-based GWAS of imputed SNPs revealed novel genomic variants in (or near) PTPRG, OSBPL6, and PDCL3 that influence risk for Alzheimer's Disease. rs7609954 in the gene PTPRG, rs1347297 in the gene OSBPL6, and rs1513625 near PDCL3. In addition, rs72953347 in OSBPL6 and two SNPs in the gene CDKAL1 showed marginally significant association with LOAD (rs10456232, P-value=4.76 x 10-7; rs62400067, P-value=3.54 x 10-7). PMID: 26830138
4. Results demonstrate that PTPRG plasmatic form (sPTPRG) represent a novel candidate protein biomarker in plasma whose increased expression is associated to hepatocyte damage. PMID: 25775014
5. Our results showed that there was no significant association between any of five reported SNPs of TCF4 and PTPRG genes and the occurrence of Fuchs' endothelial dystrophy; only rs7640737 in PTPRG showed an increased risk for corneal dystrophy. PMID: 23758498
6. SNPs in PTPRG were not associated with FCD in Caucasians. PMID: 25299301
7. PTPRG is a JAK2 phosphatase that negatively regulates leukocyte integrin beta2 activation. PMID: 25624455
8. Mutations in PDGFRB cause infantile myofibromatosis while a mutation in PTPRG may act as an aggravating factor. PMID: 25158255
9. Germline polymorphisms in PTPRG gene is associated with lung adenocarcinoma. PMID: 25196286
10. PTPRG expression induces dephosphorylation of ERK, a downstream RAS target that may be critical for mutant RAS-induced cell growth. PMID: 24496747
11. found that the RPTP-gamma, RPTP-gamma(V948I, S970T) and RPTP-gamma(C858S, S970T) proteins could be stored at 193 K in their respective crystallization buffers without affecting crystallization or crystal quality PMID: 21795790
12. Tumor-specific methylation of the first intron of the receptor protein-tyrosine phosphatase gamma gene was found in both sporadic and Lynch syndrome colorectal cancers. PMID: 21150880
13. Downregulation of Protein tyrosine phosphatase receptor type {gamma} is associated with chronic myeloid leukemia. PMID: 20959494
14. PTPRG inhibited breast tumor formation in vivo; PTPRG may up-regulate p21(cip) and p27(kip) proteins through the ERK1/2 pathway. PMID: 20651337
15. findings implicate PTPRG, PTPRZ and CNTNs as a group of receptors and ligands involved in the manifold recognition events that underlie the construction of neural networks PMID: 20133774
16. There were significant differences of PTPRG gene methylation and PTPRG mRNA expression between gastric primary cancer and lymph node metastases. PMID: 18646686
17. both estradiol-17beta and zeranol regulate PTPgamma expression in human breast; epithelial-stromal cell interaction is important in regulation of PTPgamma expression by estrogenically active agents PMID: 11859871
18. Estrogenic down-regulation of protein tyrosine phosphatase gamma (PTP gamma) in human breast is associated with estrogen receptor alpha. PMID: 12553013
19. PTPgamma may function as an important modulator in regulating the process of tumorigenesis in human breast. PMID: 14676845
20. Promoter hypermethylation of PTPRG is associated with cutaneous T-cell lymphoma PMID: 15897551
21. Significant difference exists in methylation of gene PTPRG between primary tumor and metastatic lymph nodes of gastric cancer. PMID: 17963294
22. PTPRG may contribute to tumorigenesis. PMID: 18829573

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HGNC: 9671

OMIM: 176886

KEGG: hsa:5793

STRING: 9606.ENSP00000418112

UniGene: Hs.595541