Recombinant Human Regulator of G-protein signaling 4 (RGS4)

1. Study investigated whether RGS4 could participate in signalling pathways to regulate neurotropic events. These observations suggest that RGS4 is implicated in opioid dependent neuronal differentiation and neurite outgrowth via a "non-canonical" signaling pathway regulating STAT5B-directed responses. PMID: 28219718
2. Data support the notion that the Galpha, but not Gbetagamma, arm of the Gi/o signalling is involved in TRPC4 activation and unveil new roles for RGS and RGS4 in fine-tuning TRPC4 activities. PMID: 26987813
3. The results of this study demonstrated the association between the variation in the regulator of G-protein signaling 4 (RGS4) gene, a putative candidate gene for psychosis previously associated with schizophrenia endophenotypes, and psychotic-like experiences (PLEs). PMID: 26910404
4. All of these results confirmed the critical role of RGS4 in NSCLC progression. PMID: 26640232
5. After alphao dissociates from MOR, RGS4 remains bound to the C-terminal region of MOR PMID: 26119705
6. RGS4 deletion results in a predisposition to atrial fibrillation from enhanced activity in the G-protein pathway, resulting in abnormal calcium release and corresponding electrical events. PMID: 26088132
7. RGS2 and RGS4 are new interacting partners that play key roles in G protein coupling to negatively regulate kappa-OmicronR signaling. PMID: 25289860
8. RGS4 and COMT risk variants are associated with brain structural alterations in patient with schizophrenia. PMID: 23911251
9. genetic association study in Chinese Han population: Data suggest an SNP in RGS4 (rs10759) is associated with increased predisposition to schizophrenia via down-regulation of miroRNA (MIRN124) binding to 3-prime-untranslated region of RGS4 mRNA. PMID: 23332465
10. The results suggest unaltered membrane RGS4 and cytosolic RGS10 proteins levels in schizophrenia and major depression. PMID: 23093381
11. dramatic up-regulation of RGS4 expression in the nucleus accumbens of subjects treated with monoamine-directed antidepressants PMID: 23630294
12. Lack of association between the regulator of G-protein signaling 4 (RGS4) rs951436 polymorphism and schizophrenia. PMID: 22157635
13. Cys-2 and Cys-12 play markedly different roles in the regulation of RGS4 membrane localization, intracellular trafficking, and G(q) inhibitory function via mechanisms that are unrelated to RGS4 protein stabilization. PMID: 22753418
14. RGS4 gene variations specifically disrupt prefrontal control of saccadic eye movements. PMID: 21910931
15. These studies indicate that increased RGS4 expression promotes a phenotypic switch of airway smooth muscle, evoking irreversible airway obstruction in subjects with severe asthma. PMID: 22253691
16. The researchers found evidence that there were significant differences between the D1S1656 locus in the Maghreb population and other populations. PMID: 21674833
17. RGS4 and RGS10 proteins are detected in postmortem prefrontal cortex. PMID: 20816714
18. Opioid-induced down-regulation of RGS4: role of ubiquitination and implications for receptor cross-talk. PMID: 21209077
19. RGS4 polymorphisms are associated with variations in cognitive functions and contribute a small but statistically significant proportion of variance in a family-based sample. PMID: 19282471
20. Localization of Sst2 to the projection prevents excess G-protein activation during the pheromone response. PMID: 20712983
21. RGS4 is a potential susceptible gene for bipolar disorder. PMID: 20414142
22. A novel mechanism involving coordinated regulation of nuclear levels and acetylation of NF-YA and Bcl6 activates RGS4 transcription. PMID: 20630860
23. A homogeneous sample of 280 schizophrenia patients and 230 healthy controls of Hungarian, Caucasian descent were genotyped for polymorphisms in schizophrenia candidate genes NRG1, DTNBP1, RGS4, G72/G30, and PIP5K2A. PMID: 19937977
24. cytosolic and membrane levels of RGS4 may contribute to the regional differences in the coupling of muscarinic M1 receptors in Alzheimer's disease PMID: 12422374
25. A significant decrease in the transcript encoding regulator of G-protein signaling 4 (RGS4) in the prefrontal cortex of patients with schizophrenia. PMID: 12436019
26. results suggest that palmitoylation of a Cys residue in the regulator of G protein signaling(RGS) box is critical for RGS16 and RGS4 GAPase activating protein activity and their ability to regulate G protein signaling in mammalian cells PMID: 12642592
27. The data of this research give modest support for the hypothesis that the regulator of G-protein signaling 4 is a susceptibility gene for schizophrenia. PMID: 14732600
28. RGS4 mRNA distribution in human postmortem tissue from normal persons was very dense in most cortical layers examined, with lower density in the basal ganglia and thalamus. PMID: 15182322
29. Results could be interpreted as supporting evidence for the association between RGS4 and schizophrenia. PMID: 15274033
30. RGS4 and beta-tubulin modulate Galpha-GDP and Galpha-GTP states thus modulating MT1 melatonin receptor function. PMID: 15369705
31. RGS4 polymorphisms are associated with alterations in dorsolateral prefrontal cortex (area 9) volumes among schizophrenic patients. PMID: 15381923
32. Although gross indices of signaling were unaffected by RGS4, it slowed the rate of increase in Ins(1,4,5)P3 levels. PMID: 15383626
33. In schizophrenia, significant case-control differences were not observed, though the TDT suggested transmission distortion. For bipolar disorder, an omnibus test suggested differences in the overall distribution of haplotypes bearing all four SNPs. PMID: 15660667
34. No association is identified between RGS4 single nucleotide polymorphism (SNP) markers, genotypes, or haplotypes and schizophrenia PMID: 16082709
35. Data do not directly replicate previous associations of RGS4, but association with SNP 7 in the Scottish population provides some support for a role in schizophrenia susceptibility. PMID: 16176390
36. These results provide the first demonstration of a Ca(2+)-dependent interaction between RGS4 and CaM in vivo and show that association in lipid rafts of the plasma membrane might be involved in this physiological regulation of RGS proteins. PMID: 16246308
37. Finding weakens the evidence that mutations or variation in the RGS4 gene have an effect on schizophrenia susceptibility. PMID: 16508931
38. Results fail to support the RGS4 as a candidate gene for schizophrenia when evaluated with three SNP markers from promoter region and intron 1. PMID: 16526029
39. RGS4 is an example of a molecule that may underlie increased vulnerability through either genetic or non-genetic mechanisms, which we suggest may be typical of other genes in a complex, polygenic disorder such as schizophrenia. PMID: 16860780
40. Genetic polymorphisms within RGS4 are unlikely to confer an increased susceptibility to the etiology of schizophrenia. PMID: 16904822
41. RGS4 mRNA was inversely correlated with COMT enzyme activity in the dorsolateral prefrontal cortex PMID: 16905560
42. SNPs in RGS4, G72, GRM3, and DISC1 showed evidence for significant statistical epistasis with COMT. PMID: 17006672
43. RGS4 single nucleotide polymorphism impacts frontal lobe blood oxygenation level-dependent response and network coupling during working memory and results in reductions in gray, white matter structural volume in individuals carrying the A allele. PMID: 17301167
44. In RGS4, the G-allele of the previously reported SNP RGS4-1 (single and as part of haplotypes with SNP RGS4-18) was associated with non-deficit schizophrenia but not with deficit schizophrenia. PMID: 17410640
45. study identified all common RGS4 polymorphisms & evaluated patterns of linkage disequilibrium in relation to schizophrenia; 2 haplotypes reported to confer liability to SZ had significant promoter activity suggesting functional role for both haplotypes PMID: 17515439
46. RGS4 genotypes predicted both the severity of baseline symptoms and relative responsiveness to antipsychotic treatment in patient with schizophrenia. PMID: 17588543
47. Full length cloning and expression analysis of splice variants of RGS4 were performed. PMID: 17707117
48. the association of regulator of G-protein signalling 4 protein polymorphisms with the phenotypic subgroups of schizophrenia. PMID: 17722013
49. The isolation and characterization of a novel human RGS4 mutant which displays enhanced or gain-of-function (GOF) activity, is described. PMID: 18031991
50. RGS4 variances influence clinical manifestations of schizophrenia PMID: 18204343

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HGNC: 10000

OMIM: 181500

KEGG: hsa:5999

STRING: 9606.ENSP00000397181

UniGene: Hs.386726