Recombinant Human Regulator of chromosome condensation (RCC1)

1. This study provides first evidence for a mutation in RCC1 as a breast cancer susceptibility allele PMID: 29363114
2. Importin alpha3 facilitates the nuclear transport of the Ran guanine nucleotide exchange factor RCC1. PMID: 29042532
3. this study has demonstrated that EBNA1 and RCC1 closely associate on the chromosomes during metaphase, suggesting an essential role for the interaction during this phase, perhaps in tethering EBNA1 to mitotic chromosomes. PMID: 28284242
4. RCC1 expression enables the proliferation of cells that sustain DNA damage. RCC1-dependent activation of Ran accelerates cell cycle and DNA repair, inhibiting DNA damage-induced cell senescence. PMID: 26864624
5. RCC1 expression is frequently lost in poorly differentiated gastric cell lines and gastric carcinoma tissues. Loss of RCC1 expression is correlated with tumor differentiation and depth of invasion. PMID: 26823742
6. stress can disrupt the Ran gradients through RCC1-dependent and RCC1-independent mechanisms PMID: 25452301
7. PI3Kbeta regulates the nuclear envelope through upstream regulation of RCC1 and Ran PMID: 25348717
8. RCC1 facilitates a tight binding between the encephalomyocarditis virus leader and cellular Ran GTPase. PMID: 23536659
9. RCC1 can induce bipolar spindle formation. Remarkably, RCC1 beads oscillate within spindles from pole to pole, a behavior that could be converted to a more typical, stable association by the addition of a kinesin together with RCC1. PMID: 22215983
10. discovery of the first alpha-N-methyltransferase, which we named N-terminal RCC1 methyltransferase (NRMT). PMID: 20668449
11. The authors find that RCC1 uses a conformationally flexible loop region we have termed the switchback loop in addition to its N-terminal tail to bind to the nucleosome. PMID: 20347844
12. RanBP3 associates with the Ran-specific guanine nucleotide exchange factor, regulator of chromosome condensation 1 (RCC1). PMID: 11932251
13. These results indicate that the generation of Ran-GTP in the vicinity of chromosomes by RCC1 is important for the fidelity of mitotic spindle assembly in human cells. PMID: 12194828
14. RCC1 release from chromatin in vitro requires a factor(s) distinct from, or in addition to, Ran PMID: 14565978
15. phosphorylation of the NLS of RCC1 is required to prevent the binding of importin alpha and beta to RCC1, thereby allowing RCC1 to couple RanGTP production to chromosome binding PMID: 15014043
16. This 30 kb deletion contains the exons coding for the RCC1-like domain of RPGR. It is the first report of a macrodeletion that spans the entire RCC1-like domain of RPGR in X-linked retinitis pigmentosa patients PMID: 16052169
17. HSV-1 replication is blocked in cell line tsBN2 encoding a temperature sensitive RCC1 protein. PMID: 17251553
18. Propose bimodal attachment mechanism for RCC1 in which the tail promotes stable RCC1 association with chromatin through DNA binding in an alpha-N-methylation-dependent manner. PMID: 17435751
19. These results show that human RCC1 isoforms have distinct chromatin binding properties, different molecular interactions, and are selectively regulated by phosphorylation, as determined by their different NTRs. PMID: 17855385
20. chromosome 1p36 was established to have linkage for adhd. PMID: 18439570
21. A review of the function and structure of RCC1 and RCC1 superfamily genes and proteins. PMID: 18442486
22. reduced binding affinity of RCC1 to the mitotic chromosome, which led to a reduction of RanGTP level. PMID: 18712773
23. The N-terminal tail of RCC1 is essential for association with DNA but inhibits histone binding. PMID: 18762580
24. Therefore, we propose that RCC1 reads the histone code created by caspase-activated Mst1 to initiate apoptosis by reducing the level of RanGTP in the nucleus. PMID: 19060893

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HGNC: 1913

OMIM: 179710

KEGG: hsa:1104

UniGene: Hs.469723