Recombinant Human Reticulon-4-interacting protein 1, mitochondrial (RTN4IP1)

Code CSB-YP848832HU
MSDS
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Source Yeast
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Code CSB-EP848832HU
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Source E.coli
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Code CSB-EP848832HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP848832HU
MSDS
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Source Baculovirus
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Code CSB-MP848832HU
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
RTN4IP1
Uniprot No.
Alternative Names
MGC12934; mitochondrial; NIMP; NOGO interacting mitochondrial protein; NOGO-interacting mitochondrial protein; Reticulon 4 interacting protein 1; Reticulon 4 interacting protein 1, mitochondrial; Reticulon-4-interacting protein 1; RT4I1_HUMAN; Rtn4ip1
Species
Homo sapiens (Human)
Expression Region
41-396
Target Protein Sequence
TVMPAWVIDK YGKNEVLRFT QNMMMPIIHY PNEVIVKVHA ASVNPIDVNM RSGYGATALN MKRDPLHVKI KGEEFPLTLG RDVSGVVMEC GLDVKYFKPG DEVWAAVPPW KQGTLSEFVV VSGNEVSHKP KSLTHTQAAS LPYVALTAWS AINKVGGLND KNCTGKRVLI LGASGGVGTF AIQVMKAWDA HVTAVCSQDA SELVRKLGAD DVIDYKSGSV EEQLKSLKPF DFILDNVGGS TETWAPDFLK KWSGATYVTL VTPFLLNMDR LGIADGMLQT GVTVGSKALK HFWKGVHYRW AFFMASGPCL DDIAELVDAG KIRPVIEQTF PFSKVPEAFL KVERGHARGK TVINVV
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Plays a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve. Appears to be a potent inhibitor of regeneration following spinal cord injury.
Gene References into Functions
  1. Recessive Mutations in RTN4IP1 Cause Isolated and Syndromic Optic Neuropathies. PMID: 26593267
  2. RTN4IP1 has a tumor-suppressive function and may regulate thyroid cancer progression. PMID: 23393170
Involvement in disease
Optic atrophy 10 with or without ataxia, mental retardation, and seizures (OPA10)
Subcellular Location
Mitochondrion outer membrane.
Protein Families
Zinc-containing alcohol dehydrogenase family, Quinone oxidoreductase subfamily
Tissue Specificity
Widely expressed in mitochondria-enriched tissues. Found in heart, muscle, kidney, liver, brain and placenta.
Database Links

HGNC: 18647

OMIM: 610502

KEGG: hsa:84816

STRING: 9606.ENSP00000358059

UniGene: Hs.155839

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