Recombinant Human Retinoic acid receptor responder protein 3 (RARRES3), partial

1. RIG-I and MDA5 receptor sensing of host non-coding RNAs facilitates the cell-intrinsic immune response to Kaposi's sarcoma-associated herpesvirus infection. PMID: 30451863
2. we observed frameshift mutations of RARRES3 in 11 cases of colorectal cancer PMID: 29496306
3. Data demonstrate that RIG-1 is activated after mitochondrial SUMOylation by MAPL which is an essential process for the mitochondrial antiviral signaling response. PMID: 28273895
4. Low RIG1 expression is associated with Arenaviral infections. PMID: 29669840
5. Conclusively, these data demonstrate the MCPIP1 contributes to attenuate influenza A virus-induced host antiviral response by suppressing RIG-I expression. PMID: 28892164
6. Oncostatin M induces RIG-I and MDA5 expression and enhances the double-stranded RNA response in fibroblasts. PMID: 28560754
7. Identified the tumor suppressor RARRES3 as a critical target of G9a. Epigenetic silencing of RARRES3 contributed to the tumor-promoting function of G9a PMID: 28532996
8. Results provide evidence that RIG-I as an essential mediator for influenza A virus-induced COX-2 expression. PMID: 27265729
9. perifascicular pattern of RIG-I expression supports the diagnosis of dermatomyositis PMID: 28738907
10. The current study establishes that hypoxia can profoundly influence the inducible RIG-I protein expression in malignant cells of both human and murine origin, whereas this phenomenon was not identified in nonmalignant cell lines or primary cells. PMID: 28468914
11. our study demonstrates that the novel pathway lncRNA Ftx/miR-545/RIG-I promotes hepatocellular carcinoma development PMID: 26992218
12. this review describes antiviral activities of RIG-I against influenza viruses (standing on three legs) PMID: 27318973
13. Study uncovered a novel aspect of Rig-I in monitoring gut microbiota through regulating IgA and IL6-STAT3-dependent Reg3gamma pathway. Besides, Rig-I loss could also promote colorectal cancer progression both in the presence and absence of intestinal bacteria. PMID: 28057020
14. a novel mechanism of pattern recognition receptor modulation by HCV and suggests a biological function of the HCV alternate reading frame in the modulation of host innate immunity PMID: 27404108
15. this study indicated that increased expression of TIG3 in primary glioblastoma is a novel biomarker for predicting poor outcome of patients. We then hypothesize that TIG3 may function in a different pattern in glioblastoma PMID: 28639915
16. Foot-and-mouth disease virus Viroporin 2B antagonizes RIG-I-mediated antiviral effects by inhibition of its protein expression. PMID: 27707918
17. Overexpression of TIG3 suppresses tumor growth in hepatocellular carcinoma PMID: 26951515
18. miR-34a is an antioncogene in multiple tumors, in this study, RIG-I and miR-34a suppressed cell growth, proliferation, migration, and invasion in cervical cancer cells in vitro. miR-34a was validated as a new regulator of RIG-I by binding to its 3' untranslated region and upregulating its expression level. PMID: 26910120
19. TRIM25 plays an additional role in RIG-I/MDA5 signaling other than RIG-I ubiquitination via activation of NF-kappaB. PMID: 26299329
20. These observations highlight the importance of RIG-I signaling in anti-HIV innate immunity in macrophages, which may be beneficial for the treatment of HIV and aid in the understanding of the neuropathogenesis of HAND. PMID: 26535695
21. Gal1 and gal3 regulate the inflammatory response in airway epithelial cells exposed to microbial neuraminidase by modulating the expression of SOCS1 and RIG1. PMID: 26355912
22. findings provide a new insight into the molecular link between p53, protein acylation and Wnt/beta-catenin signaling whereby RARRES3 plays a pivotal role in modulating the acylation status of signaling proteins. PMID: 25361079
23. During Crimean-Congo hemorrhagic fever virus infection, RIG-I mediated a type I interferon response via MAVS. PMID: 26223644
24. the flexible main loop of H-REV107, but not that of TIG3, is critical for its NTD to modulate its CTD in inducing cell death. PMID: 25871522
25. Viral pseudo-enzymes activate RIG-I via deamidation to evade cytokine production. PMID: 25752576
26. critical for the initiation of IRF-3 phosphorylation, dimerization and downstream gene expression during antiviral innate immune response PMID: 24800889
27. RARRES3 downregulation engages metastasis-initiating capabilities by facilitating adhesion of the tumor cells to the lung parenchyma. PMID: 24867881
28. MiR-545 exerts its effects in pancreatic ductal adenocarcinoma by directly targeting RIG-1 PMID: 25315416
29. These findings argue that TIG3 is involved in the control of keratinocyte differentiation and that loss of TIG3 in transformed cells contributes to the malignant phenotype. PMID: 24599174
30. We show that the C-terminal hydrophobic domain targets intact TIG3 to the plasma membrane, but when isolated as an independent element localizes at the mitochondria and a segment of the N-terminal hydrophilic region targets the centrosome. PMID: 24401997
31. Low RIG1 expression is associated with testis cancer. PMID: 22960220
32. RIG1 gene is a downstream target of p53 in cancer cell lines PMID: 22616991
33. Data suggest that pericentrosomal localization of TIG3 is a key event that results in microtubule and microfilament redistribution and pericentrosomal organelle clustering and that leads to cancer cell apoptosis. PMID: 21858038
34. We conclude that TG1-catalysed cross-linking, regulated by TIG3, might play an important role in the formation of neuronal tau inclusions in certain tauopathies PMID: 22009441
35. induction of TIG3 is associated with the suppression of anchorage-independent growth in certain aerodigestive tract cancer cells PMID: 12879006
36. TIG3 facilitates the terminal stages in keratinocyte differentiation via activation of type I transglutaminase PMID: 12928434
37. altered RARRES3 expression may play a role in the carcinogenesis of the liver and biliary tract. PMID: 15742394
38. identification and characterization of the functional RA response element that is responsible for the RA-mediated induction of RIG1 gene PMID: 15850806
39. TIG3 is negatively regulated by an activated MEK-ERK signaling pathway in ovarian carcinoma. PMID: 15856468
40. The proapoptotic and anti-RAS activities of RIG1 are primarily associated with the Golgi localization of the protein. PMID: 17196792
41. the TIG3 N-terminal region is required for TIG3-dependent keratinocyte differentiation, and its removal converts TIG3 into a proapoptotic protein PMID: 17762858
42. The NC domain, especially the NC motif, plays the major role in RIG1-mediated pro-apoptotic activity. The RIG1(111-123) dodecapeptide exhibited strong pro-apoptotic activity and has potential as an anticancer drug. PMID: 19245694
43. The tumor suppressors TIG3, HRASLS2 and H-rev107 are involved in the phospholipid metabolism with different physiological roles. PMID: 19615464

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HGNC: 9869

OMIM: 605092

KEGG: hsa:5920

STRING: 9606.ENSP00000255688

UniGene: Hs.17466