Recombinant Human Ribosomal RNA processing protein 1 homolog A (RRP1)

Code CSB-YP020526HU
MSDS
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Source Yeast
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Code CSB-EP020526HU
MSDS
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Source E.coli
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Code CSB-EP020526HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP020526HU
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP020526HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
RRP1
Uniprot No.
Alternative Names
D21S2056E; NNP 1; NNP-1; NNP1; Nnp1 homolog nucleolar protein; NOP52; Novel nuclear protein 1; Nucleolar protein Nop52; Nucleolar protein, 52-KD; Protein NNP 1; Protein NNP1; Ribosomal RNA processing 1; Ribosomal RNA processing 1 homolog; Ribosomal RNA processing 1 homolog (S. cerevisiae); Ribosomal RNA processing protein 1 homolog A; Ribosomal RNA processing protein 1, S. cerevisiae, homolog of; rrp1; RRP1 like protein; RRP1-like protein; RRP1_HUMAN; RRP1A
Species
Homo sapiens (Human)
Expression Region
1-461
Target Protein Sequence
MVSRVQLPPE IQLAQRLAGN EQVTRDRAVR KLRKYIVART QRAAGGFTHD ELLKVWKGLF YCMWMQDKPL LQEELGRTIS QLVHAFQTTE AQHLFLQAFW QTMNREWTGI DRLRLDKFYM LMRMVLNESL KVLKMQGWEE RQIEELLELL MTEILHPSSQ APNGVKSHFI EIFLEELTKV GAEELTADQN LKFIDPFCRI AARTKDSLVL NNITRGIFET IVEQAPLAIE DLLNELDTQD EEVASDSDES SEGGERGDAL SQKRSEKPPA GSICRAEPEA GEEQAGDDRD SGGPVLQFDY EAVANRLFEM ASRQSTPSQN RKRLYKVIRK LQDLAGGIFP EDEIPEKACR RLLEGRRQKK TKKQKRLLRL QQERGKGEKE PPSPGMERKR SRRRGVGADP EARAEAGEQP GTAERALLRD QPRGRGQRGA RQRRRTPRPL TSARAKAANV QEPEKKKKRR E
Protein Length
Full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Plays a critical role in the generation of 28S rRNA.
Gene References into Functions
  1. The data suggest that RRP1 is involved not only in competitive binding with fibrillarin to C1QBP on 90S but also in site 2 cleavage in ITS1 of pre-rRNAs at early stages of human ribosome biogenesis. PMID: 25969445
  2. p32 is a new rRNA maturation factor involved in the remodeling from pre-90S particles to pre-40S and pre-60S particles that requires the exchange of FBL for Nop52. PMID: 21536856
  3. NNP-1 expression in neuroblastoma PMID: 12209604
Subcellular Location
Nucleus, nucleolus.
Protein Families
RRP1 family
Tissue Specificity
Ubiquitously expressed in fetal and adult tissues.
Database Links

HGNC: 18785

OMIM: 610653

KEGG: hsa:8568

STRING: 9606.ENSP00000417464

UniGene: Hs.110757

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