Recombinant Human SHC SH2 domain-binding protein 1 (SHCBP1)

Code CSB-YP847699HU
MSDS
Size Pls inquire
Source Yeast
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-EP847699HU
MSDS
Size Pls inquire
Source E.coli
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-EP847699HU-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-BP847699HU
MSDS
Size Pls inquire
Source Baculovirus
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-MP847699HU
MSDS
Size Pls inquire
Source Mammalian cell
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Purity
>85% (SDS-PAGE)
Target Names
SHCBP1
Uniprot No.
Alternative Names
FLJ22009; PAL; Protein expressed in Activated Lymphocytes; SHC binding and spindle associated 1; SHC SH2 domain-binding protein 1; SHCBP_HUMAN; Shcbp1
Species
Homo sapiens (Human)
Expression Region
2-672
Target Protein Sequence
ADGSLTGGG LEAAAMAPER MGWAVEQELA SLEKGLFQDE DSCSDCSYRD KPGSSLQSFM PEGKTFFPEI FQTNQLLFYE RFRAYQDYIL ADCKASEVQE FTAEFLEKVL EPSGWRAVWH TNVFKVLVEI TDVDFAALKA VVRLAEPYLC DSQVSTFTME CMKELLDLKE HRLPLQELWV VFDDSGVFDQ TALAIEHVRF FYQNIWRSWD EEEEDEYDYF VRCVEPRLRL HYDILEDRVP SGLIVDYHNL LSQCEESYRK FLNLRSSLSN CNSDSEQENI SMVEGLKLYS EMEQLKQKLK LIENPLLRYV FGYQKNSNIQ AKGVRSSGQK ITHVVSSTMM AGLLRSLLTD RLCQEPGEEE REIQFHSDPL SAINACFEGD TVIVCPGHYV VHGTFSIADS IELEGYGLPD DIVIEKRGKG DTFVDCTGAD IKISGIKFVQ HDAVEGILIV HRGKTTLENC VLQCETTGVT VRTSAEFLMK NSDLYGAKGA GIEIYPGSQC TLSDNGIHHC KEGILIKDFL DEHYDIPKIS MVNNIIHNNE GYGVVLVKPT IFSDLQENAE DGTEENKALK IQTSGEPDVA ERVDLEELIE CATGKMELCA RTDPSEQVEG NCEIVNELIA ASTQKGQIKK KRLSELGITQ ADDNLMSQEM FVGIVGNQFK WNGKGSFGTF LF
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells.
Gene References into Functions
  1. SHCBP1 was found highly expressed in SS cell lines and tissues, which was linked to the poor clinical prognosis and was implicated in SS aggressive progression. SHCBP1 regulated invasion and metastasis by modulating the TGF-beta1/Smad signaling pathway and promoting the EMT in SS. PMID: 29020987
  2. Data indicate that the oncogene SS18-SSX1 promotes tumorigenesis by increasing the expression of SHC SH2-domain binding protein 1 (SHCBP1), which normally acts as a tumor promoting factor. PMID: 27572315
  3. Immunohistochemical analysis revealed SHCBP1 was significantly up-regulated in breast cancer tissues compared with adjacent normal tissues (82 of 128, 64%). Over-expressed SHCBP1 was correlated with advanced clinical stage and poorer survival. Ablation of SHCBP1 inhibited the proliferation in vitro. PMID: 27129942
  4. This study gives novel insight into the role of SHCBP in cytokinesis completion. PMID: 25486361
  5. Knockdown of SHCBP1 induced cell cycle delay. PMID: 24289556
  6. The central region of SHCBP1 was found to bind to measles virus C protein, as well as the phosphoprotein, but the two viral proteins did not compete for SHCBP1 binding. PMID: 23804634

Show More

Hide All

Subcellular Location
Midbody. Cytoplasm, cytoskeleton, spindle.
Database Links

HGNC: 29547

OMIM: 611027

KEGG: hsa:79801

STRING: 9606.ENSP00000306473

UniGene: Hs.123253

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2025 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1