Recombinant Human SRSF protein kinase 3 (SRPK3)

Code CSB-YP892486HU
MSDS
Size Pls inquire
Source Yeast
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Code CSB-EP892486HU
MSDS
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Source E.coli
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Code CSB-EP892486HU-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP892486HU
MSDS
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Source Baculovirus
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Code CSB-MP892486HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
SRPK3
Uniprot No.
Alternative Names
MSSK-1; MSSK1; Muscle specific serine kinase 1; Muscle-specific serine kinase 1; Serine/arginine rich protein specific kinase 3; Serine/arginine-rich protein-specific kinase 3; Serine/threonine protein kinase 23; Serine/threonine protein kinase SRPK3; Serine/threonine-protein kinase 23; SFRS protein kinase 3; SR-protein-specific kinase 3; Srpk3; SRPK3_HUMAN; SRSF protein kinase 3; STK 23; STK23
Species
Homo sapiens (Human)
Expression Region
1-567
Target Protein Sequence
MSASTGGGGD SGGSGGSSSS SQASCGPESS GSELALATPV PQMLQGLLGS DDEEQEDPKD YCKGGYHPVK IGDVFNGRYH VVRKLGWGHF STVWLCWDIQ RKRFVALKVV KSAGHYTETA VDEIKLLKCV RDSDPSDPKR ETIVQLIDDF RISGVNGVHV CMVLEVLGHQ LLKWIIKSNY QGLPVPCVKS IVRQVLHGLD YLHTKCKIIH TDIKPENILL CVGDAYIRRL AAEATEWQQA GAPPPSRSIV STAPQEVLQT GKLSKNKRKK MRRKRKQQKR LLEERLRDLQ RLEAMEAATQ AEDSGLRLDG GSGSTSSSGC HPGGARAGPS PASSSPAPGG GRSLSAGSQT SGFSGSLFSP ASCSILSGSS NQRETGGLLS PSTPFGASNL LVNPLEPQNA DKIKIKIADL GNACWVHKHF TEDIQTRQYR AVEVLIGAEY GPPADIWSTA CMAFELATGD YLFEPHSGED YSRDEDHIAH IVELLGDIPP AFALSGRYSR EFFNRRGELR HIHNLKHWGL YEVLMEKYEW PLEQATQFSA FLLPMMEYIP EKRASAADCL QHPWLNP
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development.
Gene References into Functions
  1. SRPK3 expression is significantly downregulated in human masticatory mucosa during wound healing PMID: 28005267
  2. Alternative splicing of the alpha-exon of MEF2C regulates myogenesis. Loss of SRPK3 in rhabdomyosarcoma cells inhibits this splicing and blocks differentiation. PMID: 25404735
Protein Families
Protein kinase superfamily, CMGC Ser/Thr protein kinase family
Tissue Specificity
Exclusively expressed in skeletal and heart muscle.
Database Links

HGNC: 11402

OMIM: 301002

KEGG: hsa:26576

STRING: 9606.ENSP00000359119

UniGene: Hs.104865

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