Recombinant Human Serine/threonine-protein kinase WNK1 (WNK1), partial

1. SNP rs1468326 of WNK1, rs6749447 of STK39, and WNK1 haplotype AGACAGGAATCGT were associated with hypertension in Tibetan individuals PMID: 28945285
2. A new WNK1/HSN2 founder mutation has been found in Japanese patients with hereditary sensory and autonomic neuropathy. PMID: 28422281
3. Small interfering RNA knockdown of MAPK7 demonstrated that MAPK7 regulates a subset of WNK1-regulated genes and controls the migration and cell proliferation PMID: 29025069
4. The AA genotype of WNK1 rs1468326 is related with an increased risk for preeclampsia. PMID: 29777907
5. Mutated WNK1 is a driver of chronic lymphocytic leukemia. PMID: 28679620
6. Using small-interfering RNA-mediated WNK1 knockdown, we show autophagosome formation and autophagic flux are accelerated. In cells with reduced WNK1, basal and starvation-induced autophagy is increased. We also show that depletion of WNK1 stimulates focal class III phosphatidylinositol 3-kinase complex (PI3KC3) activity, which is required to induce autophagy. PMID: 27911840
7. WNK1 and the associated phosphorylation of the PCF11 CID act to promote transcript release from chromatin-associated Pol II, which in turn facilitates mRNA export to the cytoplasm PMID: 29196535
8. Akt3 constitutively suppresses macropinocytosis in macrophages through a novel WNK1/SGK1/Cdc42 pathway. PMID: 28389565
9. NKCC1 and KCCs are coordinately regulated by L-WNK1 isoforms. PMID: 27170636
10. Single nucleotide polymorphisms STK39 and WNK were associated with hypertension and BP in our multicenter Belgian case-control study PMID: 27082544
11. Identify a new chimeric transcript generated by the fusion of WNK1 and B4GALNT3 genes, correlated with B4GALNT3 overexpression in papillary thyroid carcinoma. PMID: 25803323
12. a novel gene, WNK1, for susceptibility to pelvic organ prolapse PMID: 25739019
13. findings indicate that the proline-rich exons are modular cassettes that convert WNK1 into a NEDD4-2 substrate, thereby linking aldosterone and other NEDD4-2-suppressing antinatriuretic hormones to NCC phosphorylation status. PMID: 26241057
14. enhances BK channel function by reducing ERK1/2 signaling-mediated lysosomal degradation of the channel PMID: 25145935
15. conclude that although multiple candidate genes are involved in development of hypertension, the genetic polymorphism in WNK1 is not a major contributor to the observed variability in blood pressure and familial clustering risk of hypertension PMID: 25321950
16. study identifies a separation of functions for the WNK1-activated protein kinases OSR1 and SPAK in mediating proliferation, invasion, and gene expression in endothelial cells PMID: 25362046
17. Report generation of WNK1 knockout cell lines and effects on WNK signaling. PMID: 25477473
18. data suggest that WNK1 functions as a chloride sensor through direct binding of a regulatory chloride ion to the active site, which inhibits autophosphorylation PMID: 24803536
19. our data show a novel role for the WNK1/OSR1/NKCC1 pathway in glioma migration PMID: 24555568
20. Findings suggest that inactivating mutations in WNK1 may cause hypokalemic salt-losing tubulopathies (SLT). PMID: 22934535
21. Wnk kinases are positive regulators of canonical Wnt/beta-catenin signaling. PMID: 23797875
22. The WNK1 gene might be mechanistically involved in the variation in BP response to dietary sodium and potassium intake among individuals, and might contribute to the variation of this complex phenotype. PMID: 23059770
23. Data show that intracellular association between WNK1 and oxidative stress-responsive 1 (OSR1) is required for stimulation of OSR1 and Na(+), K(+), Cl(-)-Cotransporter NKCC1 and NKCC2 activities by osmotic stress. PMID: 22989884
24. The results evidenced a striking tissue-specific distribution of the different isoforms and the unexpected presence of exon HSN2 in many tissues other than the nervous system. PMID: 22701532
25. review focuses on the mechanisms by which deletions of the first intron of WNK1 found in pseudohypoaldosteronism type 2 patients trigger the disease PMID: 22080857
26. WNK1 stimulates PLC-beta signaling in cells by promoting the synthesis of PIP2 via stimulation of phosphatidylinositol 4-kinase IIIalpha. PMID: 22119528
27. hypertension associated polymorphisms in WNK1 and WNK4 may not be predictors for antihypertensive response to diuretics. PMID: 21704025
28. we report a novel mutation in the WNK1/HSN2 gene in HSAN2 disease PMID: 21625937
29. WNK1 AluYb8 insertion might affect human blood pressure via altering the profile of alternatively spliced transcripts PMID: 21520334
30. These results suggested that WNK1 polymorphisms were involved in the predisposition of essential hypertension in Hani and Yi populations and its effects showed a clear population specificity. PMID: 21530900
31. Both IRBIT (inositol 1,4,5-trisphosphate receptor-binding protein) and WNK [with no lysine (K)] kinase have been implicated as additional HCO(3)(-) secretory controllers. PMID: 21242704
32. PI3K-activating hormones inhibit ROMK by enhancing its endocytosis via a mechanism that involves phosphorylation of WNK1 by Akt1 and SGK1. PMID: 21355052
33. Data show that a large percentage of WNK1 knockdown cells fail to complete cell division, displaying defects in mitotic spindles and also in abscission and cell survival. PMID: 21220314
34. IRBIT opposes the effects of WNKs and SPAK by recruiting PP1 to the complex to dephosphorylate CFTR and NBCe1-B, restoring their cell surface expression, in addition to stimulating their activities PMID: 21317537
35. WNK1 promotes cell surface expression of glucose transporter GLUT1 by regulating a Tre-2/USP6-BUB2-Cdc16 domain family member 4 (TBC1D4)-Rab8A complex PMID: 20937822
36. Three different truncating mutations of HSN2 is associated with hereditary sensory and autonomic neuropathy PMID: 15060842
37. Screening of hsn2 gene in an HSAN type II Lebanese family showed a 1bp deletion mutation found in a homozygous state in all affected individuals. PMID: 15455397
38. Two founder mutations are responsible for the apparently higher prevalence of HSAN2 in French Canadians. Genotype-phenotype correlation does not suggest any significant clinical variability. PMID: 15911806
39. HSN2 mutations are associated with an early childhood onset of a predominantly sensory neuropathy. PMID: 16534117
40. HSN2 is a nervous system-specific exon of the WNK1 gene (WNK1/HSN2 isoform). PMID: 18521183
41. identification of autoinhibitory domain PMID: 12374799
42. Protein kinase B mediates the phosphorylation of WNK1 at Thr-60. PMID: 14611643
43. control of kidney WNK1 gene expression of kinase-active or -deficient isoforms is mediated predominantly through the use of multiple transcription initiation sites PMID: 14645531
44. WNK1 selectively binds to and phosphorylates synaptotagmin 2 (Syt2) within its calcium binding C2 domains. Endogenous WNK1 and Syt2 coimmunoprecipitate and colocalize on a subset of secretory granules in INS-1 cells. PMID: 15350218
45. stimulation of KS-WNK1 expression might be an important element of aldosterone-induced Na(+) retention and hypertension PMID: 15583131
46. WNK kinase may be able to influence ion homeostasis through its effects on synaptotagmin function (review) PMID: 15686619
47. WNK1 is activated by hypertonic stress. WNK1 phosphorylated both WNK4 and WNK2. In addition, the WNK1 autoinhibitory domain inhibited the catalytic activity of these WNKs. PMID: 15883153
48. Polymorphisms in genes regulating renal sodium transport, in particular WNK1, predict interindividual differences in antihypertensive responses to hydrochlorothiazide. PMID: 16172412
49. WNK1 and SPAK/OSR1 mediate the hypotonic stress signaling pathway to cation-chloride-coupled cotransporters PMID: 16263722
50. role of WNK1 in blood pressure regulation; interactions of functional variants of WNK1 with dietary intake or with response to antihypertensive drugs, and their impact on cardiovascular morbidity and mortality PMID: 16301342

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HGNC: 14540

OMIM: 201300

KEGG: hsa:65125

STRING: 9606.ENSP00000313059

UniGene: Hs.744906