Recombinant Human Single-stranded DNA-binding protein, mitochondrial (SSBP1)

1. This study identified SSBP1 as a putative N6-methyldeoxyadenosine binding protein. PMID: 30412255
2. NEIL1 and homotetrameric mtSSB form a larger ternary complex in presence of DNA, however, the tetrameric form of mtSSB gets disrupted by NEIL1 in the absence of DNA as revealed by the formation of a smaller NEIL1-mtSSBmonomer complex. PMID: 29522991
3. These results indicated that SSDBP1 may induce cell chemoresistance of cisplatin through promoting DNA repair, resistance-related gene expression, cell proliferation, and inhibiting apoptosis. PMID: 28210897
4. Data show that single-stranded DNA binding protein 1 (hSSB1/NABP2/OBFC2B) forms a tetramer and is stabilized by two cysteines (C81 and C99) as well as a subset of charged and hydrophobic residues. PMID: 28609781
5. DNA synthesis determines the binding mode of the human mtSSB. PMID: 28486639
6. The data presented in this study suggests that while SSBP1 has predominantly been considered in a DNA repair context, it is likely to have roles in many other cellular processes. In particular, the identification of numerous proteins with roles in mRNA metabolism, transcriptional transactions and ribosomal processes, may suggest these as important areas of SSBP1 function. PMID: 27938330
7. Data suggest that human mitochondrial SSB shares many physicochemical properties with E coli SSB and that the differences may be explained by the lack of an acidic, disordered C-terminal tail in human mitochondrial SSB protein. (SSB = single-stranded DNA-binding protein) PMID: 28615444
8. Data suggest that human mitochondrial SSB and E coli SSB both protect and expose single-stranded DNA; implications from these studies toward understanding DNA replication and DNA repair abound. (SSB = single-stranded DNA-binding protein) [EDITORIAL] PMID: 28778884
9. hSSB1 is directly phosphorylated by DNA-PK at serine residue 134. While this modification is largely suppressed in undamaged cells by PPP-family protein phosphatases, S134 phosphorylation is enhanced following the disruption of replication forks and promotes cellular survival. PMID: 28448822
10. The stimulatory effect of mtSSB on Pol gamma on these ssDNA templates is not species-specific. PMID: 26446790
11. This study determined that hSSB1 acetylation at K94 mediated by the acetyltransferase p300 and the deacetylases SIRT4 and HDAC10 impaired its ubiquitin-mediated degradation by proteasomes. PMID: 26170237
12. SSBP1 protects cells from proteotoxic stresses by potentiating stress-induced HSF1 transcriptional activity PMID: 25762445
13. Fbxl5 interacts with and targets hSSB1 for ubiquitination and degradation, which could be prevented by ATM-mediated hSSB1 T117 phosphorylation. PMID: 25249620
14. In response to the DNA damage response, INTS3-hSSB1-INTS6 complex relocates to the DNA damage sites. PMID: 23986477
15. Results indicate that hSSB1 may regulate DNA damage checkpoints by positively modulating p53 and its downstream target p21. PMID: 23184057
16. mtSSB potentially prevents formation of DNA breaks in ssDNA, ensuring that base removal primarily occurs in dsDNA. PMID: 23290262
17. Local enrichment of UNG1 at DNA-bound mtSSB may furthermore facilitate rapid access to- and processing of the damage once the dsDNA conformation is restored. PMID: 22153281
18. mtSSB uses distinct structural elements to interact functionally with its mtDNA replisome partners and to promote proper mtDNA replication in animal cells PMID: 21953457
19. hSSB1 may positively modulate p21 to regulate cell cycle progression and DNA damage response, implicating hSSB1 as a novel, promising therapeutic target for cancers such as hepatocellular carcinoma PMID: 21242961
20. Results describe the role of mitochondrial single-stranded DNA binding protein in the maintenance of mitochondrial DNA in cultured human cells. PMID: 20434493
21. Data show that mtSSB bound both CKS1 and CKS2 and underwent CDK-dependent phosphorylation. PMID: 19786724
22. SSDP1 gene encodes a protein with a conserved N-terminal FORWARD domain;The SSDP1 mRNA transcripts are distributed ubiquitously in adult human and mouse tissues. PMID: 12479417
23. PDIP38 is located in the mitochondrial matrix. TFAM and mitochondrial single-stranded DNA binding protein (mtSSB) are co-immunoprecipitated with PDIP38 PMID: 16428295
24. Zta interaction with mtSSB serves the dual function of facilitating viral and blocking mitochondrial DNA replication. PMID: 18305033
25. Identification of human mitochondrial SSB (HmtSSB) as a novel protein-binding partner of tumour suppressor p53, in mitochondria. PMID: 19066201
26. hSSB1 and hSSB2 form two separate complexes with similar structures, and both complexes participate in DNA damage response. PMID: 19605351
27. following DNA damage, SSB1 and Integrator3 relocate to the DNA damage sites and regulate the accumulation of TopBP1 and BRCA1 there PMID: 19759019

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HGNC: 11317

OMIM: 600439

KEGG: hsa:6742

STRING: 9606.ENSP00000265304

UniGene: Hs.490394