Recombinant Human Sodium- and chloride-dependent neutral and basic amino acid transporter B (0+) (SLC6A14), partial

Code CSB-YP890764HU
MSDS
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Source Yeast
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Code CSB-EP890764HU
MSDS
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Source E.coli
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Code CSB-EP890764HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP890764HU
MSDS
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Source Baculovirus
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Code CSB-MP890764HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
SLC6A14
Uniprot No.
Alternative Names
SLC6A14; Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+; Amino acid transporter ATB0+; Solute carrier family 6 member 14
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner.
Gene References into Functions
  1. Together, these findings suggest that SLC6A14 activity plays a role in the modification of the initial stages of airway infection by altering the level of l-arginine in the airway surface liquid, which in turn affects the attachment of Pseudomonas aeruginosa. PMID: 29259090
  2. SLC6A14 was up-regulated several fold in patient-derived pancreatic cancer xenografts, primary tumour tissues and pancreatic cancer cells lines compared to normal pancreatic tissue or normal pancreatic epithelial cells PMID: 27747870
  3. SLC6A14 and 5-HTR2C polymorphisms are associated with food intake and nutritional status in children. PMID: 26160208
  4. results indicate a significant correlation between T132903C and C109869T single nucleotide polymorphisms in the insulin receptor and solute carrier family 6 member 14 amino acid transporter(SLC6A14) genes with idiopathic infertility in Persian males PMID: 27172637
  5. Very little is known about the role of SLC6A14 in PDAC and our results demonstrate that this target merits further investigation as a candidate transporter for functional imaging of pancreatic ductal adenocarcinoma . PMID: 26106611
  6. Single nucleotide polymorphism in SLC6A14 gene is associated with cystic fibrosis. PMID: 22466613
  7. SLC6A14 gene is an interesting novel candidate for obesity because it encodes an amino acid transporter, which potentially regulates tryptophan availability for serotonin synthesis and thus possibly affects appetite control. PMID: 14660752
  8. association of the SLC6A14 gene locus with obesity. PMID: 15331564
  9. The up-regulation of SLC6A14 may have a pathogenic role in colorectal neoplasms. PMID: 15905073
  10. The SLC6A14 gene encodes the transport protein known as the beta-alanine carrier which, due to its broad substrate specificity, is likely to play an important role in absorption of essential nutrients and drugs. PMID: 18599538
  11. The five gene transcripts (aldolase B, elafin, MST-1, simNIPhom and SLC6A14) were changed in patients with ulcerative colitis, and were related to the disease activity. PMID: 18700007

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Involvement in disease
Genetic variations in SLC6A14 may be associated with obesity in some populations, as shown by significant differences in allele frequencies between obese and non-obese individuals.
Subcellular Location
Membrane; Multi-pass membrane protein.
Protein Families
Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A14 subfamily
Tissue Specificity
Levels are highest in adult and fetal lung, in trachea and salivary gland. Lower levels detected in mammary gland, stomach and pituitary gland, and very low levels in colon, uterus, prostate and testis.
Database Links

HGNC: 11047

OMIM: 300444

KEGG: hsa:11254

STRING: 9606.ENSP00000360967

UniGene: Hs.522109

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