Recombinant Human Sodium channel subunit beta-3 (SCN3B), partial

Product Details

Purity

≥85% (SDS-PAGE)

Target Names

SCN3B

Uniprot No.

Alternative Names

1110001K16Rik; 4833414B02Rik; HSA243396; KIAA1158; MGC136997; MGC80155; Scn3b; SCN3B_HUMAN; SCNB3; Sodium channel subunit beta-3; Sodium channel, beta 3 subunit; sodium channel, voltage-gated, type III, beta

Species

Homo sapiens (Human)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Function

Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

Gene References into Functions

Contribution of Cardiac Sodium Channel beta-Subunit Variants to Brugada Syndrome. PMID: 26179811
In a nonreferred nationwide Danish cohort of SIDS cases, up to 5/66 (7.5%) of SIDS cases can be explained by genetic variants in the sodium channel complex genes. PMID: 25757662
SCN1-3B the gene that encode respectively a- and b-subunits of the cardiac fast voltage-gated sodium channel, have been linked to atrial fibrillation. PMID: 25443231
The Val110Ile mutation of SCN3B is a relatively common cause of SCN5A-negative BrS in Japan, which has a reduced sodium current because of the loss of cell surface expression of Nav1.5. PMID: 23257389
the beta3 subunit can mediate trans homophilic-binding via its Ig domain and the beta3-Ig domain can associate heterophilically with the beta1 subunit PMID: 23118027
three mutations in SCN3B were investigated electrophysiologically and all led to loss of function in the sodium current, supporting the hypothesis that decreased sodium current enhances atrial fibrillation susceptibility PMID: 21051419
The researchers found evidence of an association between SCN3B subunit mutations and sudden infant death syndrome pathogenesis. PMID: 20226894
The sodium channel {beta}3-subunit induces multiphasic gating in NaV1.3 and affects fast inactivation via distinct intracellular regions. PMID: 20675377
This study identifies the first atrial fibrillation(AF) -associated mutation in SCN3B, and suggests that mutations in SCN3B may be a new pathogenic cause of AF. PMID: 20558140
Study provides molecular and cellular evidence implicating mutations in SCN3B as a cause of idiopathic ventricular fibrillation. PMID: 20042427
SCN3B mediates a p53-dependent apoptotic pathway and may be a candidate for gene therapy combined with anticancer drugs. PMID: 15334053
In patients with temporal lobe epilepsy, Na(v)beta3 levels were dramatically reduced in the hippocampus, but not in the cortex of non-hippocampal sclerosis patients when compared to hippocampal sclerosis patients. PMID: 19385982
beta3 does not participate in trans homophilic cell-cell adhesion or associate with contactin. PMID: 19596049

Hide All

Involvement in disease

Brugada syndrome 7 (BRGDA7); Atrial fibrillation, familial, 16 (ATFB16)

Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Families

Sodium channel auxiliary subunit SCN3B (TC 8.A.17) family

Tissue Specificity

Expressed in the atrium.

Database Links

HGNC: 20665

OMIM: 608214

KEGG: hsa:55800

STRING: 9606.ENSP00000299333

UniGene: Hs.4865

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Recombinant Human Sodium channel subunit beta-3 (SCN3B), partial

Product Details

Customer Reviews and Q&A

Target Background

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