Recombinant Human Sodium/potassium/calcium exchanger 2 (SLC24A2), partial

1. a new mutation in SLC24A2 gene was identified to decrease the stability of SLC24A2 PMID: 28413183
2. Functional and structural properties of the NCKX2 Na(+)-Ca (2+)/K (+) exchanger: a comparison with the NCX1 Na (+)/Ca (2+) exchanger. PMID: 23224872
3. identified 31 residues that, when substituted, result in shifts in Na(+) affinity, either toward higher or lower K(m) values when compared with wild type NCKX2 (K(m) for Na(+) 58 mm) PMID: 20231282
4. The oligomeric state of this protein is studied. PMID: 12502543
5. This is the first systematic NCKX mutagenesis study in which 96 residues are mutated in the human cone NCKX2 cDNA, and functional consequences of these mutations are measured. PMID: 12525183
6. results appear to rule out a critical importance of an intramolecular disulfide linkage in NCKX2 protein synthesis and folding as had been reported before PMID: 15196038
7. Glu(188) and Asp(548) are the central residues of a single cation binding pocket that can accommodate both K(+) and Ca(2+). Furthermore, a single set of residues lines a transport pathway for both K(+) and Ca(2+). PMID: 15583008
8. Charge-removing replacement of Asp(575) by either asparagine or cysteine rendered the mutant NCKX2 proteins independent of K(+), whereas the charge-conservative substitution of Asp(575) to glutamate resulted in a nonfunctional mutant NCKX2 protein PMID: 15611132
9. Several residues in helix H2 of NCKX2 are in the proximity of residues in helices H8 and to aspartate575 in H9; the residues found here are conserved in NCKX1-5 isoforms. PMID: 15909993
10. PKC-mediated activation of NCKX2 is sensitive to mutation of multiple PKC consensus sites via a mechanism that may involve several phosphorylation events PMID: 17038313
11. A regulatory kinetic state of calcium (Ca2+) transport via NCKX2 Na+/Ca2+-K+ exchangers may play a prominent role in regulation of Ca2+ extrusion in cellular environments such as neuronal synapses that experience frequent and dynamic Ca2+ fluxes. PMID: 17164249
12. non-synonymous single nucleotide polymorphism in SLC24A5 alters a residue that is important for NCKX5 and NCKX2 activity PMID: 18166528

Show More

Hide All

HGNC: 10976

OMIM: 609838

KEGG: hsa:25769

STRING: 9606.ENSP00000344801

UniGene: Hs.283014