Recombinant Human Solute carrier family 2, facilitated glucose transporter member 2 (SLC2A2), partial

1. Data suggest that the following genetic modifications are involved in neonatal diabetes mellitus patients in Oman: (1) mutation in KCNJ11 (potassium voltage-gated channel subfamily J member 11; one patient); (2) mutation in GCK (glucokinase); (3) mutation in SLC2A2 (glucose transporter type 2); (4) chromosome 6q24 methylation abnormalities. PMID: 29329106
2. Results showed the glucose transporter GLUT2 was highly expressed in the lumen of sweat glands from atopic dermatitis (AD) patients. AD patients with chronic inflammation had significantly increased GLUT2 mRNA expression and near normal sweat glucose levels. PMID: 29677207
3. Data suggest expression of SGLT1 is markedly increased in kidney of patients with type 2 diabetes as compared to control subjects; SGLT1 mRNA is highly and significantly correlated with fasting and postprandial plasma glucose and HbA1c. In contrast, data suggest SGLT2 and GLUT2 mRNA in kidney are down-regulated in type 2 diabetes, but not to statistically significant level. (SGLT = sodium-glucose co-transporter) PMID: 28477418
4. The mutant tumors exhibited impaired proliferation, anoikis resistance, and migratory capability and had reduced adenylate energy charge. Further investigations also revealed that cANGPTL4 regulated the expression of Glut2 PMID: 28641978
5. Single nucleotide polymorphism in SLC2A2 gene is associated with glycemic response to metformin in Type 2 diabetes. PMID: 27500523
6. no significant associations between GLUT2 and/or TAS1R2 polymorphisms and fillings were found, but allele frequencies of the TAS1R2 variant were marginally significantly different between children with DMFT = 0 and DMFT >/=1. no significant interaction between both genes and risk of dental caries was found. GLUT2 and TASR1 polymorphisms may influence the risk of caries in the Czech population PMID: 26112465
7. Three novel variants and seven single-nucleotide polymorphisms associated with the myelomeningocele phenotype. PMID: 25776730
8. Homozygous splice-site mutation IVS8+5G>C (c.1068+5 G>C) of SLC2A2 was found in patient A and homozygous nonsense mutation c.1194T>A (p.Tyr398X) in patient B. Patient C harboured a missense mutation c.380C>A (p.Ala127Asp) PMID: 25919556
9. Data identified the last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC)and the putative tyrosine phosphatase PTPLAD1 as new regulators of Glut2(SLC2A2)translocation in HEK293 cells. SiRNA-mediated knockdown of ATIC delayed insulin response of Glut2 translocation while depletion of PTPLAD1(HACD3} strongly enhanced it in HEK293 cells. PMID: 25687571
10. A novel 6 nucleotide deletion in GLUT2 gene, a member of the facilitative glucose transporter family, is shown to be segregated with Fanconi-Bickel syndrome in an Iranian family. PMID: 25523092
11. SGLT1 or GLUT2 interact with the cytoskeleton in the intestinal epithelium during hexose absorption. PMID: 25711084
12. Mutations in the GLUT2 gene is associated with ccute metabolic acidosis in Fanconi-Bickel syndrome. PMID: 25165176
13. GLUT-2 expression may be associated with cholangiocarcinogenesis of large bile duct and is a helpful marker for detecting high-grade biliary intraepithelial neoplasia lesions in atypical bile ducts. PMID: 24824030
14. SGLT1 mRNA and GLUT2 mRNA expression are reduced significantly in CACo-2 cells exposed to berry extracts. PMID: 24236070
15. the first gain of function mutations for hGLUT2, revealing the importance of its receptor versus transporter function in pancreatic beta cell development and insulin secretion. PMID: 23986439
16. associated with caries risk PMID: 23257979
17. This study determined if single nucleotide polymorphisms in genes involved in fructose transport,SLC2A2 and SLC2A5 and metabolism, etohexokinase affect inter-individual variability in metabolic phenotypes. PMID: 23341889
18. Intestinal dehydroascorbic acid (DHA) transport is mediated by the facilitative sugar transporters, GLUT2 and GLUT8 PMID: 23396969
19. Genetic variant SLC2A2 is marginally associated with risk of cardiovascular disease in type 2 diabetes mellitus patients. PMID: 23185617
20. Mutation analysis of the GLUT2 gene in three unrelated Egyptian families with Fanconi-Bickel syndrome detected three different mutations. PMID: 22350464
21. Case-control analyses revealed a unique association between the G allele of rs9875793 and bipolar disorder patients with 'negative mood delusions' compared with controls. PMID: 23010768
22. GLUT2 gene expression is suppressed in Hepatitis C virus infection via downregulation of HNF-1alpha expression at transcriptional and posttranslational levels. PMID: 22993150
23. The finding that patients with homozygous SLC2A2 mutations can have neonatal diabetes supports a role for GLUT2 in the human beta cell. PMID: 22660720
24. Homozygous mutations in GLUT2, which cause Fanconi-Bickel syndrome, can lead to very different clinical and biochemical findings that are not limited to mild proximal renal tubulopathy but can include significant hypercalciuria. PMID: 22865906
25. report on two siblings with Fanconi-Bickel syndrome (FBS) and an unusually mild clinical course; both patients were found to be compound heterozygous for the novel GLUT2 (SLC2A2) mutations c.457_462delCTTATA (p.153_4delLI) and c.1250C>G (p.P417R) PMID: 22214819
26. Constitutive expression of GLUT2 in the apical membrane along with additional translocation of cytoplasmic GLUT2 to the apical membrane via an intact cytoskeleton and activated PKC appears responsible for enhanced carrier-mediated glucose uptake. PMID: 21943636
27. We report the first Chinese cases of Fanconi-Bickel syndrome (FBS),a rare inherited disease caused by mutations in the glucose transporter 2 gene, SLC2A2. PMID: 22145468
28. In human enterocytes, GLUT2 was consistently located in basolateral membranes; mice on a low-carbohydrate/high-fat diet for 12 months also exhibited endosomal GLUT2 accumulation and reduced glucose absorption. PMID: 21852673
29. Polyphenols, phenolic acids and tannins from strawberry and apple are potent inhibitors of GLUT2 and SGLT1 at concentrations predicted after dietary ingestion. PMID: 20564476
30. prostate cancer was inversely associated with the SLC2A2 rs5400 Thr110 allele PMID: 20142250
31. Intestinal glucose absorption by the apical GLUT2 pathway can be 3 to 5-times greater then by SGLT1 et the high concentration of sugar. PMID: 20201351
32. Genetic polymorphisms of SLC2A2 and HP is associated with serum cholesterol levels. PMID: 20066028
33. mutated in patients with fanconi-Bickel syndrome PMID: 11810292
34. Hepatocyte nuclear factor-1alpha recruits the transcriptional co-activator p300 on the GLUT2 gene promoter. PMID: 11978637
35. polymorphisms at positions -269, -44, or + 103 may affect GLUT2 gene transcription, possibly associated with reduced expression of the GLUT2 gene in NIDDM patients. PMID: 12017192
36. Expression is responsible for resistance to alloxan and streptozotocin toxicity. PMID: 14614558
37. We have found GLUT-2 and glucokinase mRNAs in several brain regions, including the ventromedial and arcuate nuclei of the hypothalamus PMID: 15009676
38. SNPs of SLC2A2 predict the conversion to diabetes in obese subjects with impaired glucose tolerance. PMID: 15983230
39. identify Glut2 as a GroPIns transporter in mammals, and define a physiologically relevant cell-permeation mechanism PMID: 17141226
40. kidney of diabetic rats, an initial and transient upregulation of GLUT2 was induced specifically by insulin only. PMID: 17204838
41. recent progress in elucidating the transcriptional regulation of GLUT2 in the liver and pancreatic beta-cells and the relevance to type 2 diabetes.[RREVIEW] PMID: 18220613
42. Data show that glucose transport in human airway epithelial cells in vitro and in vivo utilises GLUT2 transporters, and suggest that these transporters could contribute to glucose uptake/homeostasis in the human airway. PMID: 18239936
43. Our findings show that a genetic variation in GLUT2 is associated with habitual consumption of sugars, suggesting an underlying glucose-sensing mechanism that regulates food intake. PMID: 18349384
44. The contribution of GLUT2 to human metabolic diseases (Review) PMID: 19223655
45. combined presence of rs5393 & rs5394 polymorphisms of GLUT2 was more frequent in type 2 diabetics than non-diabeteics; rs5394 appeared to be associated with decreased glucose stimulated insulin release & a tendency to a reduced GLUT2 gene expression PMID: 19269875
46. The expression pattern of GLUT2 is reported in newly diagnosed esophageal adenocarcinoma by means of immunohistochemistry. PMID: 19554504

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HGNC: 11006

OMIM: 138160

KEGG: hsa:6514

STRING: 9606.ENSP00000323568

UniGene: Hs.167584