Recombinant Human Sortilin-related receptor(SORL1) ,partial

Code CSB-YP821688HU
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Source Yeast
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Code CSB-EP821688HU
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Source E.coli
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Code CSB-EP821688HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP821688HU
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Source Baculovirus
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Code CSB-MP821688HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names SORL1
Uniprot No. Q92673
Alternative Names C11orf32; FLJ21930; FLJ39258; gp250; LDLR relative with 11 ligand binding repeats; LDLR relative with 11 ligand-binding repeats; Low density lipoprotein receptor relative with 11 ligand binding repeats; Low-density lipoprotein receptor relative with 11 ligand-binding repeats; LR 11; LR11; LRP 9; LRP9; Mosaic protein LR11; SORL 1; SORL_HUMAN; SORL1; SorLA 1; SorLA; SorLA-1; Sortilin related receptor; Sortilin related receptor L(DLR class) A repeats containing; Sortilin-related receptor; Sorting protein related receptor containing LDLR class A repeats; Sorting protein-related receptor containing LDLR class A repeats
Species Homo sapiens (Human)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. Involved in APP trafficking to and from the Golgi apparatus. It probably acts as a sorting receptor that protects APP from trafficking to late endosome and from processing into amyloid beta, thereby reducing the burden of amyloidogenic peptide formation. Involved in the regulation of smooth muscle cells migration, probably through PLAUR binding and decreased internalization.
Gene References into Functions
  1. Data show that amyloid precursor protein (APP) dimerization affects its interaction with LDL receptor related protein 1 (LRP1) and LDL-receptor related protein SorLA (SorLA), suggesting that APP dimerization modulates its interplay with sorting molecules and in turn its localization and processing. PMID: 28799085
  2. The sorting-related receptor with A-type repeats (SorLA) is a well-studied pathogenic factor for Alzheimer's and belongs to the Vps10p domain receptor family, which also encompasses sortilin and SorCS1-3. PMID: 29499509
  3. A meta-analysis identified empirical data assessing effects of a single nucleotide polymorphisms of SORL1 on Alzheimer's disease based on 14 studies involving 37941 cases and 49727 control studies; showed increased risk between single nucleotide polymorphisms (rs641120, rs1010159) and Alzheimer's disease susceptibility in Asian populations, single nucleotide polymorphisms rs641120 was detected as a decreased risk in both. PMID: 29036834
  4. This study found one SORL1 RNA transcript strongly regulated by SORL1-BDNF interactions in elderly without pathological AD and showing stronger associations with diffuse than neuritic Abeta plaques. PMID: 28322202
  5. The findings of this study suggested that three genetic variants rs2070045, rs1699102, and rs3824968 could significantly regulate SORL1 expression in human brain tissues. PMID: 28527213
  6. We conclude that rs1784933 and rs1805192 minor alleles, gene- gene interaction between rs1784933 and rs1805192, gene- environment interaction between rs1784933 and alcohol drinking, and haplotype containing the rs1784933- A and rs689021- C alleles are all associated with increased LOAD risk. PMID: 28427149
  7. Show reduced sortilin-related receptor (SORL1) expression only in neural stem cells of a patient carrying two copies of APOE4 allele with increased amyloid beta/SORL1 localization along the degenerated neurites. PMID: 28634550
  8. This study shown rare Genetic Variant in SORL1 May Increase Penetrance of Alzheimer's Disease in a Family with Several Generations of APOE-varepsilon4 Homozygosity. PMID: 27911290
  9. The C allele in SORL1 was found to be a protective factor for late-onset Alzheimer's disease in both Caucasian and Han Chinese. PMID: 26873856
  10. Report altered hippocampal functional connectivity in carriers with risk APOE epsilon4 or SORL1 G-allele, which may predispose these risk-allele carriers to be susceptible for Alzheimer disease. PMID: 28229235
  11. There was no significant association between single nucleotide polymorphisms (SNPS) of GAB2 rs2373115 (G > T) and PICALM rs541458 (C > T) and Alzheimer's disease (AD). The allele T of rs3851179 in PICALM was associated with a 13 % increase in the risk of AD. Seven SNPs on SORL1 were significantly associated with AD. PMID: 26611835
  12. Its genetic variation contributes to pathogenesis of Alzheimer disease. PMID: 28789839
  13. SORL1 variations influence the atrophy of specific Alzheimer disease-related brain structures, suggesting the potential role of SORL1 in the neurodegeneration of cognitive related regions. PMID: 27177090
  14. These findings elucidate how the SORL1 variants shape the neural system to modulate age-related cognitive decline and support the hypothesis that SORL1 may represent a candidate gene for late-onset Alzheimer's disease. PMID: 27779372
  15. Weight loss dieting in overweight and obese individuals with T2D resulted in a reduction in plasma sLR11 levels that was associated with improvements in lipid-profile and glycemic state PMID: 27697674
  16. These results demonstrate a novel role for SORLA as a physiological and pathological EphA4 modulator. PMID: 29114064
  17. Using three different patient cohorts of early onset Alzheimer disease (AD), study describes three SORL1 variants that segregate with disease in three families adding to the literature which supports SORL1 as a major player in AD pathoetiology. PMID: 28595629
  18. SORL1 variant characteristics associated with variant pathogenicity were identified in Alzheimer disease cohort. PMID: 28537274
  19. The results of this study support the effect of SORL1 gene on the disease risks and pathognomonic surrogates of Alzheimer's disease and mild cognitive impairment. PMID: 28034305
  20. Study provides the first evidence that the sortilin-related receptor 1 gene is associated with brain functional connectivity density differences in healthy young adults. PMID: 26627482
  21. Analysis of the molecular mechanism for the association of SORL1 with obesity: there is a genetic link between neurodegeneration and metabolism that converges on the receptor SORLA PMID: 27322061
  22. This review will provide a comprehensive overview of the evidence implicating SORLA-mediated protein sorting in neurodegenerative processes, and how receptor gene variants in the human population impair functional receptor expression in sporadic but possibly also in autosomal-dominant forms of Alzheimer's disease. PMID: 27638701
  23. SorLA ectodomain, released from the cell membrane upon enzymatic cleavage of full-length SorLA, may act as an IL-6 carrier protein that stabilizes IL-6 and its capacity for trans signaling. PMID: 28265003
  24. observed a 1.5-fold enrichment of rare non-synonymous variants of sortilin-related receptor 1 in Alzheimer's disease patients PMID: 27026413
  25. This review article discusses the molecular mechanisms that govern sorting of SORLA and its cargo in multiple cell types, and why genetic defects in this receptor results in devastating diseases. [review] PMID: 27832290
  26. The presence of rare coding variants in SORL1 in three different European American cohorts: early-onset, late-onset AD (LOAD) and familial LOAD, was examined. PMID: 27650968
  27. sLR11 levels in bile may be indicative of cancer cell conditions and may serve as potential novel biomarker in patients with BTC and PC PMID: 27079357
  28. Increased sLR11 concentrations are highly associated with increased IMT as well as with FPG in middle-aged, non-obese patients with T2D. Circulating sLR11 may be a novel marker representing the pathophysiology of intimal SMCs in patients with T2D PMID: 27095609
  29. SORL1 protein is involved with late onset Alzheimer's disease. [review] PMID: 27773727
  30. The DNA methylation of the SORL1 5'-flanking region may significantly influence the manifestation of mild cognitive impairment in T2 Diabetes mellitus, and might be associated with its neurocognitive presentation. PMID: 27641082
  31. Findings provide evidence that sortilin receptor 1 rs3824968 modulates regional gray matter volume and is associated with brain trajectory during the adult lifespan. PMID: 26996954
  32. Serum LR11 reflects the development of vascular lesions in patients with serious coronary artery lesions. PMID: 26761773
  33. Elevated sLR11 levels may increase the cardiovascular disease risk especially in subjects with delayed clearance of triglyceride-rich remnants, such as in familial hypercholesterolemia patients. PMID: 26520897
  34. CLF-1, based on its binding site for CLC and on two additional and independent sites for CNTFRalpha and sorLA, is a key player in CLC and CNTFRalpha signaling and turnover. PMID: 26858303
  35. Serum soluble LR11, a novel tumor derived biomarker associated with the outcome of patients with diffuse large B-cell lymphoma PMID: 25676033
  36. sLR11 levels in humans are shown to positively correlate with body mass index and adiposity. PMID: 26584636
  37. The findings of this study confirm that SORL1 is associated with Alzheimer's Disease and might be a potential tool for identifying Mild Cognitive Impairment subjects at high risk of conversion to lzheimer's Disease. PMID: 25881907
  38. Study suggested a sex-moderated association of the SORL1 rs2070045 polymorphism and executive function in healthy elderly PMID: 25598427
  39. Mutating recombinant human SORLA, disrupting retromer binding caused retrograde-sorting defect, endosomal accumulation, TGN, depletion, and enhanced APP processing. Disrupting the GGA interaction increased Abeta via defective anterograde lysosomal targeting. PMID: 26377460
  40. genetic polymorphism controls protein expression, which directly regulates the amount of Abeta peptides implicated in Alzheimer's disease PMID: 25772071
  41. SORL1 may be implicated in the downstream pathology in AD. PMID: 25659857
  42. circulating sLR11 levels may be a potential marker for angiographic late loss in patients after coronary stenting PMID: 25443876
  43. SORL1 risk variants influenced microstructure of white matter tracts with known susceptibility in Alzheimer's disease with consistent effect from childhood onward and predicted lower levels of mRNA expression PMID: 24166411
  44. Mutants of metal binding site M1 in APP E2 show metal specific differences in binding of heparin but not of sorLA PMID: 25835329
  45. SORL1 gene SNPs at rs689021 and rs3824966 loci show no relationship with LOAD onset in the Chinese Han population of the Hunan Changsha region. A SORL1 gene SNP at the rs1784933 locus is associated with LOAD onset, with the A allele being a risk factor. PMID: 25450149
  46. SLR11 had a positive correlation with average ATT. PMID: 24859021
  47. SORLA CR(5-8) cluster binds APP and is essential for the SorLA-dependent decrease in APP proteolysis. PMID: 25525276
  48. Brain DNA methylation in SORL1 was associated with pathological Alzheimer disease. PMID: 25365775
  49. Seventeen coding exonic variants were significantly associated with Alzheimer's disease. PMID: 25382023
  50. human-apoE-isoform-dependent differences modulate the cellular uptake of Abeta mediated by LR11/SorLA PMID: 25482438

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Involvement in disease Alzheimer disease (AD)
Subcellular Location Membrane, Single-pass type I membrane protein, Golgi apparatus, Endosome, Secreted
Protein Families VPS10-related sortilin family, SORL1 subfamily
Tissue Specificity Expressed mainly in brain, where it is most abundant in the cerebellum, cerebral cortex and the occipital pole; low expression in the putamen and the thalamus. Expression is significantly reduced in the frontal cortex of patients suffering from Alzheimer
Database Links

HGNC: 11185

OMIM: 104300

KEGG: hsa:6653

STRING: 9606.ENSP00000260197

UniGene: Hs.368592

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