Recombinant Human Stereocilin (STRC), partial

Code CSB-YP022878HU
MSDS
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Source Yeast
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Code CSB-EP022878HU
MSDS
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Source E.coli
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Code CSB-EP022878HU-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP022878HU
MSDS
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Source Baculovirus
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Code CSB-MP022878HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
STRC
Uniprot No.
Alternative Names
DFNB16; Stereocilin; STRC; STRC_HUMAN
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Essential to the formation of horizontal top connectors between outer hair cell stereocilia.
Gene References into Functions
  1. results provide strong evidence that STRC gene mutations are an important cause of nonsyndromic hearing loss-autosomal recessive in Czech hearing loss patients. PMID: 29425068
  2. STRC was the second most frequently mutated gene in patients from the Czech Republic with hearing loss PMID: 28984810
  3. Three probands with progressive mild to moderate hearing loss were found among 40 subjects with autosomal recessive non-syndromic hearing loss to segregate homozygous STRC deletions and gene to pseudogene conversion. PMID: 27469136
  4. we hypothesized that the p.Q1353X variation in the STRC gene is the causative mutation for hearing loss. PMID: 26746617
  5. STRC is a major contributor to DFNB16 congenital hearing impairment. PMID: 26011646
  6. The data suggest that STRC may be a common contributor to NBSNHI among GJB2 mutation negative probands, especially in those with mild to moderate hearing impairment. PMID: 22147502

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Involvement in disease
Deafness, autosomal recessive, 16 (DFNB16); Deafness-infertility syndrome (DIS)
Subcellular Location
Cell surface. Cell projection, kinocilium. Cell projection, stereocilium.
Protein Families
Stereocilin family
Database Links

HGNC: 16035

OMIM: 603720

KEGG: hsa:161497

STRING: 9606.ENSP00000401513

UniGene: Hs.657395

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