Recombinant Human Steroid receptor RNA activator 1 (SRA1)

1. our findings demonstrated that lncRNA SRA is highly correlated with cancer progression and cervical cancer cell proliferation and migration. Furthermore, these results indicate that lncRNA SRA may be a potential therapeutic target and prognostic marker for cervical malignancy. PMID: 29039612
2. Surprisingly, Rac1 is not located at the binding site on the Sra1 subunit of the WAVE regulatory complex previously identified by mutagenesis and biochemical data. Rather, it binds to a distinct, conserved site on the opposite end of Sra1. PMID: 28949297
3. Steroid receptor RNA activator 1-small interfering RNA treatment significantly increased ER-alpha levels but reduced ER-beta levels in endometriotic stromal cells (ESCs). PMID: 27694140
4. These findings suggest that SRA genetic variants may contribute to breast cancer risk PMID: 26967566
5. SRA1 was down expressed in HCC and its level was associated with tumor size and GLU level in patients with HCC for the first time. SRA1 may be a helpful biomarker to diagnostic HCC. PMID: 28085012
6. By studying a cohort of idiopathic hypogonadotropic hypogonadism, our findings strongly suggest that SRA1 gene function is required for initiation of puberty in humans PMID: 27086651
7. Results identified H15-H18 domains in SRA gene playing a key role in regulating ER-mediated transcription. PMID: 27406387
8. REVIEW: Biologic function and role in disease PMID: 27282881
9. in human pluripotent stem cells SRA interacts with NANOG and is important for maintenance of the pluripotent state. PMID: 26496121
10. Data suggest that expression of SRA1 (mRNA and protein) is linked to cancer cell motility (invasiveness of breast/cervical tumor cells) and regulation of gene expression. PMID: 26581859
11. lncRNA SRA expression is potentially associated with PCOS and it has positive correlation with obesity in PCOS, thereby suggesting that elevated lncRNA SRA might be an important mediator in adiposity-related processes in PCOS for susceptible individuals. PMID: 25609053
12. In endometrioma patients, the surrounding ovarian tissue steroid receptor RNA activator expression is higher compared to controls. PMID: 23749764
13. The structure is a five-helix bundle that is distinct from known RNA-binding motifs and instead is similar to the carboxy-terminal domain of the yeast spliceosome protein PRP18, which stabilizes specific protein-protein interactions. PMID: 24486609
14. NMR spectra of SRA1p in the presence of its 80-nt RNA target indicate that this protein must be part of a multi-protein complex in order to recognize its proposed RNA recognition element. PMID: 24486611
15. This study provides evidence that both ER-beta1 and SRAP could be predictive biomarkers of tamoxifen benefit in ER-alpha-negative premenopausal early breast cancer. PMID: 23579816
16. The presence of SRAP and multiple SRAP-like peptides in estrogen receptor positive breast cancer samples correlates with clinical outcome. PMID: 23907597
17. results show that the NTD of ERalpha and AR contains a novel RBM that directly binds SRA, and that STR5 can serve as a novel class of RNA inhibitor of ERalpha and AR signaling by interfering with Pus1p-mediated SRA pseudouridylation PMID: 22998747
18. A report of the first experimentally derived secondary structure of a human lncRNA, the steroid receptor RNA activator. PMID: 22362738
19. A significant (Student's t-test, P < 0.003) higher SRA-intron-1 relative expression is reported in breast tumors with higher progesterone receptor contents. PMID: 19483093
20. Alternative splicing of intron-1 is used by breast cancer cells to regulate the balance between coding and functional noncoding SRA1 RNA. PMID: 16848684
21. SRA noncoding RNA enhances myogenic differentiation and myogenic conversion of non-muscle cells through the co-activation of MyoD activity, but SRAP prevented this SRA RNA-dependant co-activation. PMID: 20855289
22. DEAD-box RNA helicase p68 (DDX5) and its associated noncoding RNA, steroid receptor RNA activator (SRA), form a complex with CTCF that is essential for insulator function PMID: 20966046
23. The data suggest unanticipated roles for SRA in glucose uptake, cellular signaling, T(3) hormone generation, and invasion/metastasis. PMID: 20219889
24. in breast cancer patients, SRAP levels were higher in estrogen receptor-alpha positive, in progesterone receptor positive & in older patients; data suggest SRAP levels may provide additional information on prognosis in a specific set of patients PMID: 19740422
25. Both transcript and protein products of the SRA1 gene co-modulate the transcriptional activity of steroid receptors. PMID: 20153324
26. Chlamydial protease CT441 interacts with SRAP1 co-activator of estrogen receptor alpha and partially alleviates its co-activation activity. PMID: 20079837
27. Reduction of coactivator expression by antisense oligodeoxynucleotides inhibits ERalpha transcriptional activity and MCF-7 proliferation PMID: 11818499
28. Results identify three new steroid receptor RNA activator (SRA-RNA) isoforms that likely encode stable proteins, and that are widely expressed in breast cancer cell lines. PMID: 12565891
29. 2.0A crystal structure of the human PXR ligand-binding domain (LBD) in complex with the cholesterol-lowering compound SR12813 and a 25 amino acid residue fragment of the human steroid receptor coactivator-1 (SRC-1) containing one LXXLL motif PMID: 12909012
30. SRA potentiates the estrogen-induced transcriptional activity of both ERalpha and ERbeta. PMID: 12943696
31. SRA is an ERalpha AF-1-specific coactivator that enhances the agonist activity of tamoxifen-bound ERalpha and may contribute to tamoxifen resistance PMID: 15351741
32. Upregulation of steroid receptor RNA activator is associated with serous Cystadenocarcinoma of the ovary PMID: 15607539
33. data suggest that the presence of both coding SRA RNA and its corresponding SRAP modifies the activity of estrogen receptor in breast cancer cells and that SRAP could be a new clinical marker for breast cancer PMID: 16152589
34. analysis of of a complex formed by the SRC1 interaction domain (SID) of CBP and the activation domain (AD1) of SRC1 PMID: 16540468
35. alternative splicing of intron-1 is one mechanism used by breast cancer cells to regulate the balance between coding and functional noncoding SRA1 RNAs PMID: 16848684
36. STAT3, Runx2, and steroid receptor coactivator-1 are critical molecules in mediating leptin-stimulated cell osteogenesis in TOLF (thoracic ossification of ligament flavum) PMID: 17702747
37. At least three genes, orthologous to loci in this LD block, HBEGF, IK, and SRA1, result independently in a phenotype of myocardial contractile dysfunction when their expression is reduced with morpholino antisense reagents. PMID: 19064678
38. These findings reveal novel functions of SRA and Dax-1 in steroidogenesis and adrenal biology. PMID: 19188450

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HGNC: 11281

OMIM: 603819

KEGG: hsa:10011

STRING: 9606.ENSP00000337513

UniGene: Hs.653135