Recombinant Human Stress-70 protein, mitochondrial (HSPA9)

1. Nfu is shown to bind to both chaperone proteins with binding affinities similar to those observed for IscU binding to the homologous HSPA9 and Hsc20, while Nfu can also stimulate the ATPase activity of HSPA9 PMID: 29211945
2. this data demonstrates that cells can sense complement activation at the plasma membrane and in response, swiftly send GRP-75 to this region in order to deactivate it PMID: 27475989
3. role of HAPA9 and its interaction with other mitochondria-related genes are not genetic risk factors for PD or AD. PMID: 28340952
4. mortalin (HSPA9) directly interacts with PP1alpha and MEK1/2 and facilitates PP1alpha-mediated dephosphorylation of MEK1/2 by promoting their physical interaction, which is important in determining cellular steady-state levels of phosphorylated MEK1/2 and, subsequently, MEK/ERK activity. PMID: 28674184
5. Identify Mortalin as a significant independent prognostic factor, in addition to location, clinical stage, and perineural invasion, for survival of pancreatic ductal adenocarcinoma patients. PMID: 28412209
6. these findings indicate that reduced levels of HSPA9 may contribute to TP53 activation and increased apoptosis observed in del(5q)-associated MDS. PMID: 28178280
7. mortalin is an oncogenic factor. PMID: 27374312
8. endocytosis vesicle enrichment of GRP75 by mitochondria trafficking upregulates clathrin-independent endocytosis through an actin cytoskeleton reorganization mechanism mediated by the concurrent activation of Cdc42 and RhoA. PMID: 27090015
9. Mortalin is up-regulated in non-small cell lung cancer, and it may be a potential biomarker of prognostic evaluation and a molecular therapeutic target for patients with early stage of non-small cell lung cancer PMID: 28349826
10. the mitochondrial stress chaperone mortalin is crucial for melanogenesis. the hyperpigmented keloid skin possesses significantly higher level of mortalin expression. mortalin is increased during oxidative stress and drug-induced melanogenesis. overexpression of mortalin causes an increase in pigmentation and its compromise leads to reduction in melanin content. PMID: 27056733
11. These findings suggest a regulatory role of human miRNA pathway especially GRP75 protein and hsa-mir-126 in dengue virus replication. PMID: 27039024
12. UBXN2A binds to mortalin's binding pocket within the substrate-binding domain of mortalin. UBXN2A increases stability of p53 protein targeted by the mortalin-CHIP E3 ubiquitin ligase. PMID: 26634371
13. Thus Hspa9 regulates erythroid differentiation through ISC cluster assembly, providing a pathophysiological mechanism for an MDS subtype characterized by HSPA9 haploinsufficiency PMID: 26702583
14. Study shows that Mortalin is upregulated in breast cancer, and may be a useful poor prognostic biomarker for patients with breast cancer. PMID: 26955804
15. This study showed that human post-mortem tissue indicated co-localization of mortalin within astrocytes. PMID: 26095919
16. Biallelic mutations in HSPA9 are associated with the EVEN-PLUS syndrome of congenital malformations and skeletal dysplasia. PMID: 26598328
17. veratridine enhances transactivation of UBXN2A, resulting in upregulation of UBXN2A in the cytoplasm, where UBXN2A binds and inhibits the oncoprotein mortalin-2 PMID: 26188124
18. Impaired stoichiometry between mtHsp40 and mtHsp70 promotes Opa1L cleavage, leading to cristae opening, decreased OXPHOS, and triggering of mitochondrial fragmentation after reduction in their chaperone function. PMID: 25904328
19. mutations in HSPA9 result in congenital sideroblastic anemia inherited as an autosomal recessive trait PMID: 26491070
20. Expression of mortalin decreased significantly in dopaminergic cells overexpressing A53T alpha-syn PMID: 25665531
21. Results present the functional structure of human mortalin showing at least two domains and interacts with adenosine nucleotides with high affinity depending on the presence of Mg2+ ions. PMID: 25615450
22. Mortalin is a key regulator of multiple signaling and metabolic pathways pivotal to medullary thyroid carcinoma cell survival and proliferation. PMID: 25435367
23. Human mot-1, R126W, or P509S mutants lack mot-2 functions involved in carcinogenesis. PMID: 25645922
24. The functional interaction of mortalin with Parkin and PINK1, was investigated. PMID: 24743735
25. Data indicate that nuclear mortalin (mot-N) efficiently protects cancer cells against endogenous and exogenous oxidative stress. PMID: 25012652
26. Mortalin-positive tumors were deeper in invasion and had more lymph node and liver metastases in gastric cancer with normal p53 function. PMID: 23828548
27. Data indicate that complement C9 binds to the ATPase domain of mortalin. PMID: 24719326
28. UBXN2A binds to mot-2 and releases sequestrated p53, which leads to p53- dependent apoptosis in colon cancer cells with high mot-2. PMID: 24625977
29. CRP40 is genetically dysregulated in Parkinson disease and presents a significant opportunity for further investigation of molecular chaperone proteins as biomarkers. PMID: 23520075
30. Bcl-2 and Bcl-xL interact with mortalin and activate p53 function leading to an induction of senescence in cancer cells. PMID: 24050266
31. Our findings demonstrated that the overexpression of Mortalin is correlated with the metastatic phenotype of HCC cells and can promote EMT, but cannot induce angiogenesis in HCC. PMID: 24190572
32. Mortalin mediates a switch in tumor-suppressive signaling of Raf/MEK/extracellular signal-regulated kinase. PMID: 23959801
33. Intracellular localization of apoptin is tightly associated with HSPA9 expression and its crucial role in cellular apoptosis. PMID: 23589050
34. The results indicate that hHep1 shares some structural similarities with the yeast ortholog despite the low identity and functional differences. PMID: 23462535
35. elevated levels of mortalin expression increase cancer cell resistance to cisplatin-induced cytotoxicity PMID: 23665506
36. mortalin and cytosolic HSP70 may have roles in colorectal cancer PMID: 23319326
37. These results suggest a possible functional role of CRP40 in the pathogenesis of schizophrenia. PMID: 23182727
38. HSPA9 secreted by oral squamous cell carcinoma cells interacts with podoplanin (PDPN) on their cell surface in an autocrine manner and regulates their growth and invasiveness PMID: 23541579
39. these data reveal the characteristic cytoplasmic sequestration of p53 by the heat shock protein mortalin in human colorectal adenocarcinoma cell lines, as is the case for other cancers, such as glioblastomas and hepatocellular carcinomas. PMID: 22683628
40. DNLZ/HEP zinc-binding subdomain is critical for regulation of the mitochondrial chaperone HSPA9. PMID: 22162012
41. Cytoprotective efficacy of mortalin under Abeta-induced stress in SH-SY5Y cells is mediated, at least in part, by inhibition of mPTP opening. PMID: 22001761
42. Nef's interaction with cellular mortalin is required for Nef secretion. PMID: 22013042
43. The present study further demonstrated that GRP75 translocates into the nucleus and physically interacts with retinoid receptors (RARalpha and RXRalpha) to augment retinoic acid-elicited neuronal differentiation. PMID: 22022577
44. Mortalin is up-regulated in liver tumors. PMID: 21714113
45. Cisplatin resistance of lung cancer cells is associated with overexpression of GRP75 gene PMID: 21496427
46. the relatively decreased mortalin expression level and its impaired interaction with Parkin could affect its roles in mitochondrial function. PMID: 21640711
47. Targeting mortalin-p53 interaction with either mortalin small hairpin RNA or a chemical or peptide inhibitor could induce p53-mediated tumor cell-specific apoptosis in hepatocellular carcinoma; p53-null hepatoma or normal hepatocytes remain unaffected. PMID: 21233847
48. These findings implicate a conserved histidine as critical for DNLZ regulation of mitochondrial HSPA9 catalytic activity. PMID: 21530495
49. Data show that mortalin can afford protection against Abeta(1-42)-induced neurotoxicity in SH-SY5Y cells. PMID: 20974113
50. the activating mechanism of mitochondrial outer membrane-bound m-calpain and the release of mitochondrial m-calpain PMID: 21145877

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HGNC: 5244

OMIM: 182170

KEGG: hsa:3313

STRING: 9606.ENSP00000297185

UniGene: Hs.184233