Recombinant Human Syntaxin-6 (STX6), partial

Code CSB-YP022902HU
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Source Yeast
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Code CSB-EP022902HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP022902HU
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Source Baculovirus
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Code CSB-MP022902HU
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
STX6
Uniprot No.
Alternative Names
LAMB2; LAMC1; Laminin B2 chain; Laminin-1 subunit gamma; Laminin-10 subunit gamma; Laminin-11 subunit gamma; STX 6; STX6; STX6_HUMAN; Syntaxin-6; Syntaxin6
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Involved in intracellular vesicle trafficking.
Gene References into Functions
  1. RABGEF1 mediates recycling endosome fusion with GAS-containing autophagosome-like vacuoles through the STX6-VAMP3-VTI1B complex; SNAREs are involved in autophagosome formation in response to bacterial infection PMID: 27791468
  2. Potent inhibition of human cytomegalovirus has been reported by modulation of host cellular STX6. PMID: 27795424
  3. the expression of STX6 was up-regulated in esophageal squamous cell carcinoma samples, and its expression was significantly correlated with tumor size, histological differentiation, lymph node metastasis and depth PMID: 26906622
  4. The compartment-specific interaction of Syntaxin 6 with v-SNARES VAMP3 and VAMP4 are controlled through an ability of Syntaxin 6 to sense cholesterol levels in the trans-Golgi network and recycling endosomes. PMID: 24746815
  5. A dityrosine motif of Ang2 interacts with a highly conserved groove in Syntaxin 6. PMID: 23932592
  6. Syntaxin 6 and VAMP4 colocalize to the chlamydial inclusion. PMID: 23798538
  7. Data indicate that depletion of VAMP4, syntaxin 6, syntaxin 16, and Vti1a disrupted the Golgi ribbon structure. PMID: 23677696
  8. Data indicate that E3 ubiquitin ligase MARCH2 co-immunoprecipitated and co-localized with CAL and syntaxin 6 (STX6), and show the ubiquitination of CFTR by MARCH2. PMID: 23818989
  9. No pathogenic mutations are found in syntaxin 6 that are associated with risk of Parkinson's disease. PMID: 23415606
  10. colocalization of ATP11B with fluorescent cisplatin and with vesicular trafficking proteins, such as STX6 and VAMP4, strongly suggests that ATP11B contributes to secretory vesicular transport of cisplatin from Golgi to plasma membrane PMID: 23585472
  11. Data suggest a new integrin trafficking pathway in which endocytosed integrins are transported from VAMP3-containing recycling endosomes to STX6-containing trans-Golgi network before being recycled to the plasma membrane. PMID: 22573826
  12. A review of the various roles of the Golgi- and endosome-localized t-SNARE, syntaxin-6, in membrane trafficking during physiological as well as pathological conditions. [Review] PMID: 22489884
  13. syntaxin 6-regulated membrane trafficking events control outside-in signaling via haptotactic and chemotactic mechanisms. PMID: 21880737
  14. COG directly and positively regulates endosome-to-TGN retrograde transport by specific and direct interaction with the t-SNARE Stx6 via its Cog6 subunit. PMID: 21807881
  15. The trans-Golgi SNARE protein syntaxin 6 is recruited to the chlamydial inclusion in a manner that requires chlamydial protein synthesis and is conserved among all chlamydial species examined. PMID: 21109560
  16. Importance of syntaxin 6 in the maintenance of cellular VEGFR2 levels.The inhibitory form of syntaxin 6 has good potential as an antiangiogenic agent. PMID: 21063020
  17. Syntaxin 6 and CAL mediate the degradation of the cystic fibrosis transmembrane conductance regulator PMID: 20130090
  18. STX6 can be induced by DNA damage and Mdm2 inhibitor Nutlin-3 in a p53-dependent manner. PMID: 18779328

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Subcellular Location
Golgi apparatus membrane; Single-pass type IV membrane protein.
Protein Families
Syntaxin family
Database Links

HGNC: 11441

OMIM: 603944

KEGG: hsa:10228

STRING: 9606.ENSP00000258301

UniGene: Hs.518417

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