Recombinant Human T-cell immunoglobulin and mucin domain-containing protein 4(TIMD4),partial

Code CSB-YP850304HU
Size Pls inquire
Source Yeast
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Code CSB-EP850304HU-B
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP850304HU
Size Pls inquire
Source Baculovirus
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Product Details

Purity >85% (SDS-PAGE)
Target Names TIMD4
Uniprot No. Q96H15
Alternative Names SMUCKLER; Spleen; mucin-containing; knockout of lymphotoxin protein; T cell immunoglobulin and mucin domain containing protein 4; T-cell immunoglobulin and mucin domain containing 4; T-cell immunoglobulin and mucin domain containing molecule; T-cell immunoglobulin and mucin domain-containing protein 4; T-cell immunoglobulin and mucin domains-containing protein 4; T-cell membrane protein 4; TIM-4; Tim4; TIMD 4; TIMD-4; Timd4; TIMD4_HUMAN
Species Homo sapiens (Human)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
(From Uniprot)
Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1 (By similarity).
Gene References into Functions
  1. These findings suggest that the TIMD4-HAVCR1 variants may be the genetic risk factors for coronary heart disease and ischemic stroke PMID: 29208769
  2. High expression of TIMD4 in clear cell renal cancer cells was closely related to short progression free survival time, and was associated with resistance to sorafenib. PMID: 28631038
  3. VitD deficiency may contribute to the pathogenesis of allergic rhinitis (AR) by increasing the TIM4 expression. The results suggest that to regulate the serum calcitriol levels and the expression of VDR in DCs may be necessary to be taken into account in the treatment of AR. PMID: 28160341
  4. This study aimed to investigate the association of two TIM-4 SNPs) with systemic lupus erythematosus (SLE)susceptibility in a Chinese Han population.The results imply that GG genotype of the TIM-4 gene at -1419 site might be associated with the disease activity of SLE. PMID: 28371471
  5. Role of TIM-4 in exosome-dependent entry of HIV-1 into human immune cells PMID: 28740388
  6. analysis of the molecular characteristics of both mTIM-4 and hTIM-4 provides a better understanding of the regions of the TIM-4 IgV domain critical for Ebola virus entry PMID: 27122575
  7. Tim-4 expression is closely associated with glioma and may have a regulatory role PMID: 26741116
  8. Data indicate that T cell immunoglobulin and mucin domain containing 4 (TIM-4) contributes, at least in part, to the pathogenesis of type 2 diabetes mellitus (T2D), possibly by regulating interleukin-1beta (IL-1beta). PMID: 25676395
  9. TIM4 binds TIM3 on the surface of polarized Th1 cells to induce Th1 cell apoptosis, which may contribute to the development of Th2-dominant immune disorders. PMID: 26403707
  10. TIM-4 rs7700944 and not TIM-1 rs41297579 G>A (-1454) is associated with rheumatoid arthritis(RA) in the present cohort of Egyptian and may be a risk factor for development of RA in Egyptian. PMID: 25899833
  11. Data showed up-regulation of TIM-4 in lung cancer tissues and a correlation with poor prognosis. Also, TIM-4 was found to promote growth of lung cancer cells by its interaction with integrin alphavbeta3 through its RGD motif. PMID: 26512878
  12. Tim-4 expression on monocytes and Tim-4 level in plasma were more highly increased in ankylosing spondylitis patients than in controls. PMID: 25359708
  13. Our results do not support an association between the rs7700944 polymorphism of the TIM-4 gene and rheumatoid arthritis PMID: 24217665
  14. Data suggest that genetic polymorphisms in ANGPTL3 (angiopoietin-like 3 protein), TIMD4 (T cell immunoglobulin mucin-4), and apolipoproteins A5 and B are among the genetic determinants of hypertriglyceridemia in Amerindian populations. [REVIEW] PMID: 24768220
  15. TIM4 expression is promoted by Cockroach allergen Bla g 7 in dendritic cells leading to Th2 polarization PMID: 24204099
  16. TIM-1 and TIM-4 are novel targets for ADAM10- and ADAM17-mediated ectodomain shedding. PMID: 24286866
  17. FG-CC' siRNA blocking interaction of Tim-1 and Tim-4 can enhance dendritic cell vaccine activity against gastric cancer. PMID: 22709877
  18. There were four SNPs in the promoter region of TIM4 in asthma patients of Chinese Han population, which were in linkage disequilibrium. PMID: 18704309
  19. TIM-4 variant or a highly correlated nearby gene of the TIM-4 gene may play a critical role in the pathogenesis of rheumatoid arthritis in many ethnicities. PMID: 22353209
  20. macrophage-derived TIM4 plays an important role in the induction of Tregs in gliomas, which may play an important role in tumor tolerance. PMID: 21896488
  21. TIM-4 gene polymorphisms are associated with asthma in a Chinese Han population. PMID: 20727045
  22. Overexpression of TIM-4 on antigen- presenting cells in transgenic mice reduces the number of antigen-specific T cells that remain after immunization, resulting in reduced secondary T cell responses. PMID: 21037090
  23. results showed that Tim-4 mRNA expression in peripheral blood mononuclear cells was significantly higher in system lupus erythematosus patients than in healthy controls, especially those patients in the active phase of disease. PMID: 20140011
  24. The polymorphism of 8570G > A in TIM4 may be associated with allergic asthma in the population of Han nationality from Hubei province of China. PMID: 17407086
  25. The results demonstrate that Staphylococcus aureus derived Staphylococcal enterotoxin B promotes the TIM4 production in human dendritic cells. PMID: 17439824
  26. TIM-4 and TIM-1 are immunologically restricted members of the group of receptors whose recognition of PS is critical for the efficient clearance of apoptotic cells and prevention of autoimmunity. PMID: 18082433
  27. Structures of T cell immunoglobulin mucin protein 4 show a metal-Ion-dependent ligand binding site where phosphatidylserine binds. PMID: 18083575
  28. Data show that the transmembrane region and cytoplasmic tail of TIM-4 are dispensable for apoptotic cell engulfment, and suggest that TIM-4 is a PtdSer tethering receptor without any direct signaling of its own. PMID: 19217291
  29. TIM4 -1419G>A polymorphism might be the genetic factor for the risk of childhood asthma in Chinese Han population. PMID: 19392790

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Subcellular Location Membrane, Single-pass type I membrane protein
Protein Families Immunoglobulin superfamily, TIM family
Database Links

HGNC: 25132

OMIM: 610096

KEGG: hsa:91937

STRING: 9606.ENSP00000274532

UniGene: Hs.334907

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