Recombinant Human Tachykinin-3 (TAC3)

1. Data suggest that basal serum neurokinin B level can be used as an adjunctive parameter to differentiate idiopathic central precocious puberty (ICPP) from premature thelarche (PT). PMID: 28008860
2. acts through NK3 receptors in granulosa cells to stimulate steroid production PMID: 27580802
3. mutations in TAC and TACR3 are not a common cause for ICPP. PMID: 24802197
4. Plasma neurokinin B level is higher in patients with NDHT, indicating an unfavorable cardiovascular prognosis. PMID: 25647283
5. Colocalization experiments provided evidence for the presence of cocaine- and amphetamine-regulated transcript (CART) in KP-immunoreactive (IR) and perikarya and in KP-IR and NKB-IR axon varicosities. PMID: 25084101
6. Amino acid substitution A63P in TAC3 gene was statistically associated with the puberty onset time in Chinese girls. PMID: 25153567
7. Copper can enter cultured astrocytoma cells and subsequently open plasma membrane calcium channels, but when bound to NKB, copper ion uptake is inhibited. PMID: 23875773
8. Expression of the gene encoding NKB (TAC3) is up-regulated 20-fold in leiomyomas, compared with matched myometrium. PMID: 23656837
9. Rare variants in the TAC3 and TACR3 genes were identified in patients with central pubertal disorders and loss-of-function variants of TACR3 were associated with the normosmic IHH phenotype. PMID: 23329188
10. Interactions between kisspeptins and neurokinin B. PMID: 23550013
11. Report neurokinin B immunoreactivity in the human brainstem. PMID: 22318412
12. Sex differences in the neurokinin B system in the human infundibular nucleus. PMID: 23019350
13. these immunohistochemical data suggest an aging-related moderate enhancement in central NKB signaling. PMID: 23011920
14. NKB neurons in the arcuate nucleus do not synthesize detectable amounts of kisspeptin and dynorphin in young male humans. These data call for a critical use of the KNDy neuron terminology when referring to the pulse generator of the hypothalamus PMID: 22903610
15. NKB/NK(3)R and kisspeptin/KISS1R are present in female peripheral reproductive tissues with colocalization of both systems in some non-neuronal cell populations of the human female genital tract. PMID: 22424618
16. The gonadotropin axis dysfunction associated with nCHH due to TAC3/TACR3 mutations is related to a low GnRH pulsatile frequency leading to a low frequency of alpha-subunit pulses and to an elevated FSH/LH ratio. PMID: 22031817
17. The significantly increased maternal plasma levels of NKB and ET-1 of patients with preeclampsia occur at early pregnancy, before the onset of clinical symptoms. PMID: 19087492
18. Future studies will be needed to determine whether NKB signaling plays a permissive role in the onset of puberty--REVIEW PMID: 20800582
19. kisspeptin and neurokinin B are coexpressed in the arcuate nucleus in the mammalian hypothalamus, suggesting that these systems are closely related and potential partners of the regulation of the reproductive axis--REVIEW PMID: 20816945
20. elevated in plasma of pre-eclamptic women PMID: 20017703
21. Data describe the distribution and sex dimorphism of kisspeptin-immunoreactive elements in hypothalami, reveal contacts between kisspeptin-immunoreactive fibers and GnRH cells, and colocalize kisspeptins and neurokinin B in the infundibular nucleus. PMID: 20529119
22. A possible association of a single nucleotide polymorphism in the tachykinin-3 gene and susceptibility to asthma are found. PMID: 20580442
23. NKB involvement in puberty is reviewed from the perspective of the regulation of puberty. PMID: 20176081
24. broad cohort of normosmic hypogonadotropic hypogonadism probands was screened for mutations in TAC3/TACR3 to evaluate the prevalence of such mutations and define the genotype/phenotype relationships PMID: 20332248
25. Possibility of a specific neuroendocrine impairment in patients with alteration of neurokinin B signaling. PMID: 20194706
26. Physiological significance of neurokinin B in the placenta and during preeclampsia. PMID: 20074343
27. study demonstrates a paracrine role for neurokinin B in the regulation of fetal placental vascular tone PMID: 12727971
28. Higher neurokinin B concentrations in normotensive pregnant women may be due to the advanced gestational age and/or the result of a negative interaction of other vasoactive substances. The role of neurokinin B in preeclampsia remains to be determined. PMID: 14634580
29. NKB plays a role in the maintenance of high placental blood flow in normal pregnancy PMID: 14700748
30. mode of vascular regulation in which GATA-1 controls NK-B synthesis in erythroid cells PMID: 15123623
31. three-dimensional structure PMID: 15317475
32. Results determined the placenta to be the main site of TAC3 expression with levels 2.6-fold higher than the brain and TAC3 expression was found to be significantly higher in pre-eclamptic placenta (1.7-fold, P < 0.05) than in normal controls. PMID: 16709596
33. Placental mRNA expression of NKB was significantly higher after term and preterm labor (P<0.001) than cesarean section, and highest after preterm labor PMID: 17561251
34. Altered circulating neurokinin B (NKB) levels in preeclampsia are not due to sequence variants in the encoding genes PMID: 17976896
35. study confirms previous reports of elevated neurokinin B levels in the plasma of preeclampsia women in the third trimester PMID: 18240076
36. Neurokinin B is a critical central regulator of human gonadal function. PMID: 19079066
37. Data show that both the TAC3 endogenous gene and its promoter are regulated, directly or indirectly, by the NRSF transcription factors resulting in both the increased expression of the endogenous gene and increased reporter gene activity. PMID: 19539370
38. A role for TAC3 neurons in the regulation of steroid negative feedback is suggested by studies of the postmenopausal human hypothalamus. PMID: 18614256

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HGNC: 11521

OMIM: 162330

KEGG: hsa:6866

STRING: 9606.ENSP00000300108

UniGene: Hs.9730