Recombinant Human Tachykinin-4 (TAC4)

Product Details

Purity

≥85% (SDS-PAGE)

Target Names

TAC4

Uniprot No.

Alternative Names

TAC4; Tachykinin-4; Preprotachykinin-C; PPT-C) [Cleaved into: Endokinin-A; EKA); Endokinin-A/B; EKA/B); Endokinin-C; EKC)]

Species

Homo sapiens (Human)

Expression Region

21-67

Target Protein Sequence

DGGEEQTLST EAETWVIVAL EEGAGPSIQL QLQEVKTGKA SQFFGLM

Protein Length

Cytoplasmic domain

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Function

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility.

Gene References into Functions

Kinase activation led to increased MMP-2 and MT1-MMP expression and melanoma cell migration induced by hHK-1. Thus, hHK-1 and the NK1 receptor are critical to melanoma cell migration and each may be a promising chemotherapeutic target PMID: 27458061
expressed in mural granulosa and cumulus cells PMID: 27146034
Expression substance P/neurokinin A/hemokinin-1 and their preferred neurokinin 1/neurokinin 2 receptors are dysregulated in uterine leiomyomata. PMID: 27456549
HKs emerge as pivotal endogenous regulators of angiogenesis through neurokinin-1 receptor PMID: 22554585
Data provide evidence for the first time that hemokinin-1, like substance P, may be involved in the pathophysiology of inflammatory bowel disease. PMID: 21342363
HK-1 and substance P are novel T helper (Th)17 cell-inducing factors that may act locally on memory T cells to amplify inflammatory responses. PMID: 21368235
Endogenous expression of hemokinin-1 is demonstrated in bronchi and is involved in contraction of airway explants. PMID: 20929541
hHK-1 and its C-terminal fragments are human NK1 receptor agonists with different functional selectivity properties and that such functional selectivity leads to differential activation of downstream signaling and receptor trafficking. PMID: 21168392
A possible association is found between a tachykinin-4 single nucleotide polymorphism and susceptibility to asthma. PMID: 20580442
Observational study of gene-disease association. (HuGE Navigator) PMID: 20580442
Results suggest that Hemokinin-1 is regulated by a unique transcription regulation system that likely governs its differential expression pattern and suggests a role for Hemokinin-1 distinct from Substance P. PMID: 19081134
Observational study and meta-analysis of gene-disease association. (HuGE Navigator) PMID: 17175032

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Subcellular Location

Secreted.

Protein Families

Tachykinin family

Tissue Specificity

Expressed at low levels in the uterus of both pregnant and non-pregnant women. Isoform 1 is found only in the adrenal gland and fetal liver. Isoform 2 is found in heart, liver, bone marrow, prostate, adrenal gland and testis. Isoform 3 and isoform 4 are e

Database Links

HGNC: 16641

OMIM: 607833

KEGG: hsa:255061

STRING: 9606.ENSP00000334042

UniGene: Hs.652130

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Recombinant Human Tachykinin-4 (TAC4)

Product Details

Customer Reviews and Q&A

Target Background

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