Recombinant Human Telomerase Cajal body protein 1 (WRAP53)

1. a unique homozygous WRAP53 mutation site underlies the development of dyskeratosis congenita in a Chinese Han family PMID: 29514627
2. Wrap53 is likely a potential oncogene or possesses oncogenic activity in colorectal cancer, promoting colorectal tumorigenesis. PMID: 30175821
3. The results collectively suggest that WDR79 and SMN play evolutionarily conserved cooperative functions in the nervous system and suggest that WDR79/TCAB1 may have the potential to modify SMA pathogenesis. PMID: 28502804
4. in response to DNA damage the Cajal body protein WRAP53beta is phosphorylated by ATM and that this phosphorylation is important for the recruitment of WRAP53beta to DNA lesions, its interaction with gammaH2AX, subsequent localization of the downstream repair factor 53BP1 to DNA breaks, as well as for HR and NHEJ repair. PMID: 27715493
5. The present findings indicate that WRAP53beta and RNF8 are rate-limiting factors in the repair of DNA double-strand breaks and raise the possibility that upregulation of WRAP53beta may contribute to genomic stability in and survival of cancer cells. PMID: 27310875
6. WDR79 colocalized and interacted with USP7 in the nucleus of non-small cell lung cancer cells. This event, in turn, reduced the ubiquitination of Mdm2 and p53, thereby increasing the stability and extending the half-life of the two proteins. PMID: 28406480
7. The depletion of WRAP53 inhibits the proliferation of lung-adenocarcinoma A549 and SPC-A-1 cells via G1/S cell-cycle arrest. Several proteins interacting with WRAP53 were identified through co-immunoprecipitation and liquid chromatography/mass spectrometry. PMID: 28347242
8. we analyzed the association between the WRAP53 gene rs2287499 C>G polymorphism and risk of cancer using five case-control studies.In the overall analysis, no significant association between rs2287499 and risk of cancer was found. PMID: 27525856
9. The interaction of MDC1 with RNF8, but not with ATM requires WRAP53beta, suggesting that WRAP53beta facilitates the former interaction without altering phosphorylation of MDC1 by ATM. PMID: 26734725
10. Moreover, our current observations identify the nuclear levels of WRAP53beta as a promising biomarker for the survival of patients with ovarian cancer. PMID: 26426684
11. the sub-cellular localization of the WRAP53 protein has a significant impact on breast cancer survival. PMID: 26460974
12. This study showed that UCA1 and WRAP53 upregulation may serve as novel serum biomarkers for hepatocellular carcinoma diagnosis and prognosis. PMID: 26551349
13. WRAP53 is associated with development and progression of esophageal squamous cell carcinoma PMID: 24626331
14. Decreasing the expression of WRAP53 using RNA interference technique can enhance the radiosensitivity. PMID: 25854392
15. The telomerase holoenzyme Cajal body-associated protein, TCAB1, was released from telomerase RNA in mitotic cells coincident with TCAB1 delocalization from Cajal bodies. PMID: 26170453
16. nuclear expression of WRAP53beta promotes tumor cell death in response to radiotherapy and is a promising predictor of radiotherapy response in patients with HNSCC PMID: 25456005
17. The data indicated that TCAB1 might facilitate the occurrence and development of head and neck carcinomas. PMID: 25070141
18. Studied the association of a frequent genetic variation in WRAP53, rs2287499 (C/G), with breast cancer risk and prognosis among Iranian-Azeri population. PMID: 25134915
19. Study finds that TRiC is required for folding the telomerase cofactor TCAB1, which controls trafficking of telomerase and small Cajal body RNAs (scaRNAs). PMID: 25467444
20. WRAP53beta as a novel regulator of DSB repair by providing a scaffold for DNA repair factors. PMID: 25512560
21. SNPs in WRAP53 (rs2287497 and rs2287498) have stronger association with an ovarian cancer risk than rs1042522 in TP53. PMID: 23192612
22. Intronic mutation outside overlapping regions of p53/wrap53 genes are associated with breast cancer. PMID: 23886136
23. Examined expression of WRAP53 protein in rectal cancers and analyzed its relationship to the response to preoperative radiotherapy and patient survival.In radiotherapy group, positive WRAP53 in the metastasis correlated with better survival. PMID: 22805008
24. although Cajal bodies are important for recruitment of telomerase, TCAB1 has an additional role in this process that is independent of these structures PMID: 22547674
25. Knockdown of the WRAP53 protein triggers massive apoptosis through the mitochondrial pathway. PMID: 21368886
26. WRAP53 mediates the interaction between SMN and associated proteins, which is important for nuclear targeting of SMN and the subsequent localization of the SMN complex to Cajal bodies PMID: 21072240
27. Compound heterozygous mutations in TCAB1 disrupt telomerase localization to Cajal bodies, resulting in misdirection of telomerase RNA to nucleoli, which prevents telomerase from elongating telomeres PMID: 21205863
28. Studies show that a linked, positively selected allele at the nearby gene WDR79 may be partly responsible for the sequence diversity profile of TP53. PMID: 19797907
29. Common variation in TP53 or WDR79 could be associated with ER negative breast cancers. PMID: 17683073
30. identification of telomerase holoenzyme subunit, TCAB1, enriched in Cajal bodies; it associates with active telomerase, telomerase components & small Cajal body RNAs; TCAB1 controls telomerase trafficking & required for telomere synthesis in cancer cells PMID: 19179534
31. We have identified a natural antisense transcript of p53, designated Wrap53, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. PMID: 19250907

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HGNC: 25522

OMIM: 612661

KEGG: hsa:55135

STRING: 9606.ENSP00000324203

UniGene: Hs.408312