Purity
Greater than 90% as determined by SDS-PAGE.
Alternative Names
mitochondrial; Selenoprotein Z; SelZ; Thioredoxin reductase 2; Thioredoxin reductase 2 mitochondrial; Thioredoxin reductase 3; Thioredoxin reductase beta; Thioredoxin reductase TR3; TR 3; TR; TR beta; TR-beta; TR3; TRXR 2; TRXR2; TRXR2_HUMAN; TXNRD 2; Txnrd2
Species
Homo sapiens (Human)
Expression Region
37-524aa
Target Protein Sequence
QRDYDLLVVGGGSGGLACAKEAAQLGRKVAVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMHQAALLGGLIQDAPNYGWEVAQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHGTRFLRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPIAIMAGRLLVQRLFGGSSDLMDYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISKRSGLDPTVTGCSG
Note: The complete sequence including tag
sequence, target protein sequence and linker sequence could be provided upon request.
Protein Length
Full Length of Mature Protein
Tag Info
N-terminal 6xHis-SUMO-tagged
Form
Liquid or Lyophilized powder
Note: We will preferentially ship the format that
we have in stock, however, if you have any special requirement for the format, please remark your
requirement when placing the order, we will prepare according to your demand.
Buffer
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the
glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer,
6% Trehalose, pH 8.0.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw
cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature
and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized
form is 12 months at -20°C/-80°C.
Lead Time
3-7 business days
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA
Please contact us to get it.
Description
Amino acids 37-524 constitute the expression domain of recombinant Human TXNRD2. The expected molecular weight for the TXNRD2 protein is calculated to be 68.9 kDa. This TXNRD2 recombinant protein is manufactured in e.coli. The N-terminal 6xHis-SUMO tag was fused into the coding gene segment of TXNRD2, making it easier to detect and purify the TXNRD2 recombinant protein in the later stages of expression and purification.
The human thioredoxin reductase 2, mitochondrial (TXNRD2) is an enzyme primarily localized in the mitochondria. TXNRD2 plays a crucial role in cellular redox homeostasis by catalyzing the reduction of thioredoxin, a key regulator of cellular redox status. This process is essential for maintaining the proper function of various cellular proteins and protecting cells from oxidative damage. Additionally, TXNRD2 contributes to the regulation of apoptosis and participates in DNA synthesis. Dysregulation of TXNRD2 has been implicated in various diseases, including cancer and neurodegenerative disorders. Research on TXNRD2 focuses on understanding its functions in cellular redox signaling, its role in health and disease, and its potential as a therapeutic target.
