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Recombinant Human Thioredoxin reductase 2, mitochondrial (TXNRD2) (U523S)

In Stock
Citations (1)
Code CSB-EP885675HU
Abbreviation Recombinant Human TXNRD2 protein (U523S)
MSDS
MSDS Datasheet
Size $224
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  • SDS-PAGE- Recombinant protein Human TXNRD2
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Product Details

Purity
Greater than 90% as determined by SDS-PAGE.
Target Names
TXNRD2
Uniprot No.
Q9NNW7
Research Area
Others
Alternative Names
mitochondrial; Selenoprotein Z; SelZ; Thioredoxin reductase 2; Thioredoxin reductase 2 mitochondrial; Thioredoxin reductase 3; Thioredoxin reductase beta; Thioredoxin reductase TR3; TR 3; TR; TR beta; TR-beta; TR3; TRXR 2; TRXR2; TRXR2_HUMAN; TXNRD 2; Txnrd2
Species
Homo sapiens (Human)
Source
E.coli
Expression Region
37-524aa(U523S)
Target Protein Sequence
QRDYDLLVVGGGSGGLACAKEAAQLGRKVAVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMHQAALLGGLIQDAPNYGWEVAQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHGTRFLRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPIAIMAGRLLVQRLFGGSSDLMDYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISKRSGLDPTVTGCSG
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
Mol. Weight
68.9kDa
Protein Length
Full Length of Mature Protein
Tag Info
N-terminal 6xHis-SUMO-tagged
Form
Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
Troubleshooting and FAQs
Protein FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
3-7 business days
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA
Please contact us to get it.
Description

Amino acids 37-524 constitute the expression domain of recombinant Human TXNRD2. The expected molecular weight for the TXNRD2 protein is calculated to be 68.9 kDa. This TXNRD2 recombinant protein is manufactured in e.coli. The N-terminal 6xHis-SUMO tag was fused into the coding gene segment of TXNRD2, making it easier to detect and purify the TXNRD2 recombinant protein in the later stages of expression and purification.

The human thioredoxin reductase 2, mitochondrial (TXNRD2) is an enzyme primarily localized in the mitochondria. TXNRD2 plays a crucial role in cellular redox homeostasis by catalyzing the reduction of thioredoxin, a key regulator of cellular redox status. This process is essential for maintaining the proper function of various cellular proteins and protecting cells from oxidative damage. Additionally, TXNRD2 contributes to the regulation of apoptosis and participates in DNA synthesis. Dysregulation of TXNRD2 has been implicated in various diseases, including cancer and neurodegenerative disorders. Research on TXNRD2 focuses on understanding its functions in cellular redox signaling, its role in health and disease, and its potential as a therapeutic target.

Citations

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TXNRD2 Proteins

Customer Reviews and Q&A

■ Customer Reviews
Average Rating:
5.0 - 1 reviews

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Applications : /

Review: Recombinant human thioredoxin reductase 2 (TrxR2) and thioredoxin reductase 3 (TrxR3) were purchased from Cusabio (#CSB-EP885675HU and CSB-EP025390HU, respectively; Wuhan, Hubei, China).

By Anonymous

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Target Background

Function
Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis. Maintains thioredoxin in a reduced state. May play a role in redox-regulated cell signaling.
Gene References into Functions
  1. Based on recent research, it has been reported that the modulation of the Trx/TrxR system may be considered as a new target in the management of the metabolic syndrome, insulin resistance, and type 2 diabetes, as well as in the treatment of hypertension and atherosclerosis. In this review evidence about a possible role of this system as a marker of the metabolic syndrome is reported. [review] PMID: 29327078
  2. TrxR2 was overexpressed in non-small-cell lung cancer cells; our results suggest that TrxR2 acts as an oncogenic gene in the context of lung cancer progression PMID: 28414076
  3. p53R2 acts as a positive regulator of TrxR2 activity in mitochondria both under normal physiological conditions and during the cellular response to DNA damage PMID: 27866984
  4. TrxR2 deficiency-induced impaired proliferation and death of chondrocytes may be the pathological mechanism of the osteoarthropathy due to Selenium deficiency. PMID: 27107686
  5. Evidence that the rs4485648 polymorphism of the TrxR2 gene might exert an independent effect on the development of Diabetic retinopathy. PMID: 26763822
  6. Data suggest that TXNRD2 may represent a druggable target that could be deployed to reduce the development of fatal pulmonary metastases in patients with osteosarcoma (OS). PMID: 26573231
  7. A meta-analysis of the top SNPs identified three new associated loci in primary open angle glaucoma--TXNRD2, ATXN2, and FOXC1 PMID: 26752265
  8. The TXNRD2 rs 1548357 polymorphism might be a genetic risk factor for Myocardial infarction in subjects with T2 Diabetes mellitus of Slovenian origin. PMID: 25703281
  9. Data suggest TXNRD1 and TXRNRD2 function at the top of a redox pyramid that governs the oxidation state of peroxiredoxins and other protein factors, thereby dictating a hierarchy of phenotypic responses to oxidative insults. PMID: 24624337
  10. Absence of TXNRD2 in humans leads to glucocorticoid deficiency. PMID: 24601690
  11. Single Nucleotide Polymorphisms in the genes GPX1 (rs1050450, rs1800668 and rs3811699), TrxR2 (rs5748469), and DIO2 (rs225014) may not be significantly associated with Kashin-Beck disease in a Tibetan population. PMID: 24058403
  12. Development of subcutaneous fibrosis can be associated with genetic variation in the mitochondrial enzyme TXNRD2, critically involved in removal of ROS, and maintenance of the intracellular redox balance. PMID: 23597419
  13. Data suggest that dietary factor (selenium supplementation) up-regulates endogenous antioxidant systems and protects trophoblasts from oxidative stress; selenium upregulates GPX1 (glutathione peroxidase 1) and thioredoxin reductases (TXNRD1; TXNRD2). PMID: 23063346
  14. A role of GPx2, TrxR2 and TrxR3 in proliferation, apoptosis and, therefore, also during cancer development. PMID: 22683372
  15. No obvious correlation can be found between rs5748469 polymorphisms in TrxR2 gene and the susceptibility to Kashin-Beck disease. PMID: 20965815
  16. Mutation of this gene is involved in regulation of cellular redoc state in Dilated Cardiomyopathy. PMID: 21247928
  17. study reveals significant differences between TrxR1 and TrxR2 in substrate specificity and metal compound inhibition in vitro and in cells PMID: 21172426
  18. mammary tumors expressing the wild-type TR were readily suppressed by the IFN/RA combination. In contrast, the tumors bearing a mutant TR were resistant to regression. PMID: 12374691
  19. Mitochondrial thioredoxin reductase and peroxiredoxin III are overexpressed in hepatocellular carcinomas. PMID: 12530083
  20. Involvements of mitochondrial thioredoxin reductase in cell proliferation. PMID: 12705894
  21. the function of TR3 is not limited to its role in Trx2 reduction PMID: 16774913
  22. Nuclear extracts from rat lungs administered this reduced recombinant protein suggest a role for NF-kappaB in proinflammatory responses. PMID: 17395017
  23. The GPX1 198 Pro/Pro and TXNRD2 370Arg/Arg genotypes might be associated with the genetic susceptibility of gastric cancer. PMID: 19035188
  24. Observations underpin a likely critical antioxidant role for TrxR2 and TrxR1 in the endothelium. PMID: 19595745
  25. Over-expression of TXNRD2, COMT and ARVCF affects incentive learning and working memory in transgenic mice. PMID: 19617637

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Subcellular Location
Mitochondrion.
Protein Families
Class-I pyridine nucleotide-disulfide oxidoreductase family
Tissue Specificity
Highly expressed in the prostate, ovary, liver, testis, uterus, colon and small intestine. Intermediate levels in brain, skeletal muscle, heart and spleen. Low levels in placenta, pancreas, thymus and peripheral blood leukocytes. According to PubMed:10608
Database Links

HGNC: 18155

OMIM: 606448

KEGG: hsa:10587

STRING: 9606.ENSP00000383365

UniGene: Hs.443430

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