TXNRD2 Antibody

Datasheet
Code CSB-PA885675ESR2HU
Size US$167Purchase it in Cusabio online store
(only available for customers from the US)
Image
  • Western blot
    All lanes: Thioredoxin reductase 2, mitochondrial antibody at 6μg/ml
    Lane 1: Mouse liver tissue
    Lane 2: Mouse gonad tissue
    Lane 3: Hela whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 57, 54, 47, 31 kDa
    Observed band size: 57 kDa

  • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA885675ESR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA885675ESR2HU at dilution of 1:100

Product Details

Full Product Name Rabbit anti-Human TXNRD2 Polyclonal antibody
Uniprot No. Q9NNW7
Target Names TXNRD2
Alternative Names Thioredoxin reductase 2, mitochondrial (EC 1.8.1.9) (Selenoprotein Z) (SelZ) (TR-beta) (Thioredoxin reductase TR3), TXNRD2, KIAA1652 TRXR2
Raised in Rabbit
Species Reactivity Human, Mouse
Immunogen Recombinant Human Thioredoxin reductase 2, mitochondrial protein (100-310AA)
Immunogen Species Human
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form Liquid
Tested Applications ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:200-1:1000
IHC 1:20-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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Citations

The novel thioredoxin reductase inhibitor A-Z2 triggers intrinsic apoptosis and shows efficacy in the treatment of acute myeloid leukemia. Dongdong Zhang, et al,Free Radical Biology and Medicine,2019

Sample type: Spleen
Sample species: Mouse
Antibody dilution factor: 1:50
Application: IHC
Review: The expression levels of TrxR1, TrxR2 , Trx1, Trx2 and IκBα detected by ICH in the spleen biopsy.
PMID: 31730934

Target Data

Function Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox-regulated cell signaling.
Subcellular Location Mitochondrion
Protein Families Class-I pyridine nucleotide-disulfide oxidoreductase family
Tissue Specificity Highly expressed in the prostate, ovary, liver, testis, uterus, colon and small intestine. Intermediate levels in brain, skeletal muscle, heart and spleen. Low levels in placenta, pancreas, thymus and peripheral blood leukocytes. According to PubMed:10608
Database Links

HGNC: 18155

OMIM: 606448

KEGG: hsa:10587

STRING: 9606.ENSP00000383365

UniGene: Hs.443430

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