TXNRD2 Antibody

Code CSB-PA885675ESR2HU
Size US$167Purchase it in Cusabio online store
(only available for customers from the US)
  • Western blot
    All lanes: Thioredoxin reductase 2, mitochondrial antibody at 6μg/ml
    Lane 1: Mouse liver tissue
    Lane 2: Mouse gonad tissue
    Lane 3: Hela whole cell lysate
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 57, 54, 47, 31 kDa
    Observed band size: 57 kDa

  • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA885675ESR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA885675ESR2HU at dilution of 1:100

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) TXNRD2 Polyclonal antibody
Uniprot No. Q9NNW7
Target Names TXNRD2
Alternative Names mitochondrial antibody; Selenoprotein Z antibody; SelZ antibody; Thioredoxin reductase 2 antibody; Thioredoxin reductase 2 mitochondrial antibody; Thioredoxin reductase 3 antibody; Thioredoxin reductase beta antibody; Thioredoxin reductase TR3 antibody; TR 3 antibody; TR antibody; TR beta antibody; TR-beta antibody; TR3 antibody; TRXR 2 antibody; TRXR2 antibody; TRXR2_HUMAN antibody; TXNRD 2 antibody; Txnrd2 antibody
Raised in Rabbit
Species Reactivity Human, Mouse
Immunogen Recombinant Human Thioredoxin reductase 2, mitochondrial protein (100-310AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form Liquid
Tested Applications ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:200-1:1000
IHC 1:20-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.


The novel thioredoxin reductase inhibitor A-Z2 triggers intrinsic apoptosis and shows efficacy in the treatment of acute myeloid leukemia. Dongdong Zhang, et al,Free Radical Biology and Medicine,2019

Sample type: Spleen
Sample species: Mouse
Antibody dilution factor: 1:50
Application: IHC
Review: The expression levels of TrxR1, TrxR2 , Trx1, Trx2 and IκBα detected by ICH in the spleen biopsy.
PMID: 31730934

Target Data

Function Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox-regulated cell signaling.
Gene References into Functions
  1. Based on recent research, it has been reported that the modulation of the Trx/TrxR system may be considered as a new target in the management of the metabolic syndrome, insulin resistance, and type 2 diabetes, as well as in the treatment of hypertension and atherosclerosis. In this review evidence about a possible role of this system as a marker of the metabolic syndrome is reported. [review] PMID: 29327078
  2. TrxR2 was overexpressed in non-small-cell lung cancer cells; our results suggest that TrxR2 acts as an oncogenic gene in the context of lung cancer progression PMID: 28414076
  3. p53R2 acts as a positive regulator of TrxR2 activity in mitochondria both under normal physiological conditions and during the cellular response to DNA damage PMID: 27866984
  4. TrxR2 deficiency-induced impaired proliferation and death of chondrocytes may be the pathological mechanism of the osteoarthropathy due to Selenium deficiency. PMID: 27107686
  5. Evidence that the rs4485648 polymorphism of the TrxR2 gene might exert an independent effect on the development of Diabetic retinopathy. PMID: 26763822
  6. Data suggest that TXNRD2 may represent a druggable target that could be deployed to reduce the development of fatal pulmonary metastases in patients with osteosarcoma (OS). PMID: 26573231
  7. A meta-analysis of the top SNPs identified three new associated loci in primary open angle glaucoma--TXNRD2, ATXN2, and FOXC1 PMID: 26752265
  8. The TXNRD2 rs 1548357 polymorphism might be a genetic risk factor for Myocardial infarction in subjects with T2 Diabetes mellitus of Slovenian origin. PMID: 25703281
  9. Data suggest TXNRD1 and TXRNRD2 function at the top of a redox pyramid that governs the oxidation state of peroxiredoxins and other protein factors, thereby dictating a hierarchy of phenotypic responses to oxidative insults. PMID: 24624337
  10. Absence of TXNRD2 in humans leads to glucocorticoid deficiency. PMID: 24601690
  11. Single Nucleotide Polymorphisms in the genes GPX1 (rs1050450, rs1800668 and rs3811699), TrxR2 (rs5748469), and DIO2 (rs225014) may not be significantly associated with Kashin-Beck disease in a Tibetan population. PMID: 24058403
  12. Development of subcutaneous fibrosis can be associated with genetic variation in the mitochondrial enzyme TXNRD2, critically involved in removal of ROS, and maintenance of the intracellular redox balance. PMID: 23597419
  13. Data suggest that dietary factor (selenium supplementation) up-regulates endogenous antioxidant systems and protects trophoblasts from oxidative stress; selenium upregulates GPX1 (glutathione peroxidase 1) and thioredoxin reductases (TXNRD1; TXNRD2). PMID: 23063346
  14. A role of GPx2, TrxR2 and TrxR3 in proliferation, apoptosis and, therefore, also during cancer development. PMID: 22683372
  15. No obvious correlation can be found between rs5748469 polymorphisms in TrxR2 gene and the susceptibility to Kashin-Beck disease. PMID: 20965815
  16. Mutation of this gene is involved in regulation of cellular redoc state in Dilated Cardiomyopathy. PMID: 21247928
  17. study reveals significant differences between TrxR1 and TrxR2 in substrate specificity and metal compound inhibition in vitro and in cells PMID: 21172426
  18. mammary tumors expressing the wild-type TR were readily suppressed by the IFN/RA combination. In contrast, the tumors bearing a mutant TR were resistant to regression. PMID: 12374691
  19. Mitochondrial thioredoxin reductase and peroxiredoxin III are overexpressed in hepatocellular carcinomas. PMID: 12530083
  20. Involvements of mitochondrial thioredoxin reductase in cell proliferation. PMID: 12705894
  21. the function of TR3 is not limited to its role in Trx2 reduction PMID: 16774913
  22. Nuclear extracts from rat lungs administered this reduced recombinant protein suggest a role for NF-kappaB in proinflammatory responses. PMID: 17395017
  23. The GPX1 198 Pro/Pro and TXNRD2 370Arg/Arg genotypes might be associated with the genetic susceptibility of gastric cancer. PMID: 19035188
  24. Observations underpin a likely critical antioxidant role for TrxR2 and TrxR1 in the endothelium. PMID: 19595745
  25. Over-expression of TXNRD2, COMT and ARVCF affects incentive learning and working memory in transgenic mice. PMID: 19617637

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Subcellular Location Mitochondrion
Protein Families Class-I pyridine nucleotide-disulfide oxidoreductase family
Tissue Specificity Highly expressed in the prostate, ovary, liver, testis, uterus, colon and small intestine. Intermediate levels in brain, skeletal muscle, heart and spleen. Low levels in placenta, pancreas, thymus and peripheral blood leukocytes. According to PubMed:10608
Database Links

HGNC: 18155

OMIM: 606448

KEGG: hsa:10587

STRING: 9606.ENSP00000383365

UniGene: Hs.443430

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