Recombinant Human Thyroid hormone receptor alpha (THRA)

1. Thyroid receptors (TRalpha and TRbeta) are major components of the thyroid hormone pathway which is linked to neuronal development. PMID: 28856816
2. overview of the clinical features together with the underlying molecular mechanisms in patients with resistance to thyroid hormone due to heterozygous mutations in TRalpha (Review). PMID: 28527577
3. We found that the thyroid hormone receptor (TRalpha 3) has a differential expression profile. Thyroid hormone is critical for normal brain development. Our results showed that there is a possible link between IGF1/IGF1R and the TRalpha 3 and that over expression of IGF1R in RTT cells may be the cause of neurites improvement in neural RTT-derived neurons. PMID: 28007906
4. This large case series underlines the variation in the clinical phenotype of RTHalpha patients. PMID: 27144938
5. THRA predominates in multipotent human adipose derived stem cells (hADSC) whereas THRB is expressed at lower levels and is upregulated during hADSC differentiation. PMID: 27732649
6. The expression of thyroid receptor alpha is linked to fertility status. PMID: 26715425
7. 8 different THRA gene abnormalities have been described in 14 patients from 9 families with phenotypes including short stature, dysmorphic syndrome, psychoneuromotor disorders, constipation and bradycardia. Review. PMID: 26585273
8. The current study aimed to investigate whether TRs may be specifically expressed in BRCA1 associated cancer cases. PMID: 26029931
9. THRA mutations may be more common than expected. In patients with clinical symptoms of mild hypothyreosis without confirmation in endocrine studies, a molecular study of THRA defects is strongly recommended. PMID: 25670821
10. Thyroid hormone receptor (TRalpha1) is shown to occur and determine postischemic remodeling and cardiac recovery depending on the availability of TH. [review] PMID: 25501869
11. Data suggest thyroid hormone resistance syndrome can be exhibited by patients with heterozygous missense mutation (Ala263Val) in THRA1 and THRA2, isoforms resulting from alternative splicing. [CASE REPORT] PMID: 24969835
12. THRalpha rs939348 polymorphism was associated with L-T4 dose and central obesity among hypothyroid patients. PMID: 25079464
13. Thyroid hormone signalling may be important in a proportion of breast cancers and THRalpha2 expression may be a regulator of signalling in this pathway. PMID: 25542270
14. substantial reduction in the protein expression profile of THRs in malignant versus nonmalignant mammary epithelium suggesting a possible role in breast cancer development. PMID: 24162265
15. A new x-ray crystallographic structure of thyroid hormone receptor ligand-binding domains shows a second binding site for thyroid hormones. PMID: 24552590
16. Transactivation of reporter genes in response to T4 thyroid hormone was dependent on the thyroid hormone receptor subtypes in human cells. PMID: 24673558
17. Thyroid hormone receptor alpha mutation is associated with a severe and thyroxine-resistant skeletal dysplasia. PMID: 24914936
18. TRalpha1 and TRbeta1, preferentially partner with distinct panels of auxiliary proteins. PMID: 24325866
19. THRA gene polymorphisms are associated with obesity development. This is a novel observation linking the THRA locus to metabolic phenotypes. PMID: 23399772
20. Mutations affecting THRA are not a common cause of high BMD in healthy euthyroid post-menopausal women. PMID: 24480136
21. Adult female with defective TRalpha defines a shared phenotype in TRalpha-mediated resistance to thyroid hormone, with differential tissue responses to T4 treatment. PMID: 23940126
22. Studies indicate that thyroid hormone receptors alpha and beta (TRTHRA and THRB) genes mutations has been identified in thyroid tumours. PMID: 23271024
23. Data from 2 patients (daughter; father) from Greece with frameshift mutation in exon 9 of TRalpha1 (F397fs406X) resulting in new type of thyroid hormone resistance suggest that some symptoms are improved with levothyroxine treatment, others are not. PMID: 23633213
24. thyroid hormone receptor action varies by subtype and could could influence physiologic and pharmacologic responses to THs and selective TR modulators (STRMs) PMID: 23300972
25. IGFBP-3 interacts with TRalpha1 and inhibits triiodothyronine responsive gene transcription. PMID: 21529443
26. conjugation of SUMO to TR has a TR-isoform preference and is important for T3-dependent gene induction and repression. PMID: 22930759
27. Thyroid hormone receptor-alpha/NR1D1 polymorphisms were not associated with baseline characteristics, including serum TSH and free thyroxine. None of the polymorphisms were associated with bone mineral density or osteoporotic fractures. PMID: 22224817
28. Our data indicates that the IGFBP-6 can interact with thyroid hormone receptor alpha 1 and interfere with heterodimer formation with retinoid x receptor PMID: 21997736
29. our study showed associations between the THRA rs939348 polymorphism and systolic blood pressure and the risk of hypertension but not with coronary heart disease. PMID: 21654857
30. TR mutations from renal clear cell carcinoma and hepatocellular carcinoma may play tissue-specific roles in carcinogenesis. PMID: 21622534
31. Differential interaction of NCoR1 with TR isoforms accounted for the TR isoform-dependent regulation of adipogenesis and that aberrant interaction of NCoR1 with TR could underlie the pathogenesis of lipid disorders in hypothyroidism. PMID: 21389087
32. investigation of association/dissociation kinetics for recombinant TRalpha and ligand (125I-T3) PMID: 21508093
33. The relationship between the genetic variability of the THRA gene and Alzheimer disease risk remains uncertain but cannot be entirely excluded. PMID: 19427062
34. Results highlight v-ErbA's complex mode of action: the oncoprotein is highly mobile and trafficks between the nucleus, cytoplasm, and aggresome, carrying out distinct activities within each compartment. PMID: 21075170
35. We found TSHR, TRalpha1, TRalpha2 and TRbeta1 mRNA and proteins expressed in human endometrium PMID: 20691434
36. Patients with non-septic shock non-thyroidal illness syndrome show decreased expression of thyroid hormone receptors THRalpha1 and THRbeta in skeletal muscle. PMID: 20736347
37. The natural TH 3,5,3'-triodothyroacetic acid (Triac) exhibits a previously unrecognized mechanism of TRbeta selectivity. PMID: 19926848
38. The presence of TRs in the penis provides the biological basis for the direct action of thyroid hormones on this organ. PMID: 20141582
39. Data suggest that CDK8 plays an important coactivator role in thyroid hormone receptor (TR)-dependent transcription by promoting Pol II recruitment and activation at TR target gene promoters. PMID: 20231357
40. A bioassay to evaluate the thyroid disrupting potential of industrial chemical using human TRalpha or TRbeta in S. cerevisiae is described. PMID: 19853653
41. Genes for TR-alpha were differentially expressed in subcutaneous vs. omental adipose tissue. Findings suggest that TR alpha1 could contribute to SC adipose tissue expandability in obese subjects. PMID: 19360007
42. A conserved lysine in the thyroid hormone receptor-alpha1 DNA-binding domain, mutated in hepatocellular carcinoma, is an allosteric sensor for transcription and contribute to neoplastic disease. PMID: 20053725
43. analysis of isoform-specific transcriptional activity of overlapping target genes that respond to thyroid hormone receptors alpha1 and beta1 PMID: 19628582
44. TR expression in human haematopoietic cells depends on thyroid function status, both hypo- and hyperthyroidism significantly influence clonogenicity and induce apoptosis in CD34(+)-enriched stem cells PMID: 19903799
45. neurodevelopmental functions of thyroid hormone signaling. PMID: 11861164
46. affected receptor amino acid sequences. lost their trans-activation function and exhibited dominant negative activity. PMID: 11889175
47. Our results reveal specific alterations in the expression of TRbeta and TRalpha genes in a subset of breast cancer patients, suggesting that deregulation of thyroid hormone target genes may be involved in the generation of this neoplasia. PMID: 12082618
48. Less aggressive thyroid cancer was found to be linked to increased thyroid hormone receptor-alpha1 expression and an expanded THRA1 microsatellite. PMID: 12231529
49. allosteric changes resulting from binding of T3Ralpha to different response elements, i.e. pHREs versus nHREs, dictate whether a cofactor will function as a coactivator or a corepressor PMID: 12388540
50. the nTRE (negative thyroid hormone response element) is responsible for binding of thyroid hormone receptor alpha to the promoter in HeLa cells PMID: 12878587

Show More

Hide All

HGNC: 11796

OMIM: 190120

KEGG: hsa:7067

STRING: 9606.ENSP00000264637

UniGene: Hs.724