Recombinant Human Transcription cofactor vestigial-like protein 4(VGLL4)

Code CSB-YP613487HU
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Source Yeast
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Code CSB-EP613487HU
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Source E.coli
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Code CSB-EP613487HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP613487HU
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Source Baculovirus
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Code CSB-MP613487HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names VGLL4
Uniprot No. Q14135
Alternative Names VGLL4; KIAA0121; Transcription cofactor vestigial-like protein 4; Vgl-4
Species Homo sapiens (Human)
Expression Region 1-290
Target Protein Sequence METPLDVLSR AASLVHADDE KREAALRGEP RMQTLPVASA LSSHRTGPPP ISPSKRKFSM EPGDEDLDCD NDHVSKMSRI FNPHLNKTAN GDCRRDPRER SRSPIERAVA PTMSLHGSHL YTSLPSLGLE QPLALTKNSL DASRPAGLSP TLTPGERQQN RPSVITCASA GARNCNLSHC PIAHSGCAAP GPASYRRPPS AATTCDPVVE EHFRRSLGKN YKEPEPAPNS VSITGSVDDH FAKALGDTWL QIKAAKDGAS SSPESASRRG QPASPSAHMV SHSHSPSVVS
Protein Length full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
May act as a specific coactivator for the mammalian TEFs.
Gene References into Functions
  1. Hippo pathway transcription factor TEAD4 directly associates with the Wnt pathway transcription factor TCF4 via their DNA-binding domains, forming a complex on target genes. VGLL4 binds to this TEAD4-TCF4 complex to inhibit transactivation of both TCF4 and TEAD4. PMID: 28051067
  2. Results identify VGLL4 as a direct target gene of miR-130b in Bladder cancer (BCa) cells. Its suppression is crucial for miR-130b-induced BCa cell proliferation, migration and invasion. PMID: 29512748
  3. The Vgll4 is phosphorylated in vitro and in vivo by cyclin-dependent kinase 1 (CDK1) during antimitotic drug-induced mitotic arrest and also in normal mitosis. PMID: 28739871
  4. VGLL4 - novel candidate genes validated in a large case-control sample of schizophrenia. PMID: 26460480
  5. The expression level of VGLL4 protein was down-regulated in gastric cancer tissues.VGLL4 inhibits epithelial-mesenchymal transition in part through suppressing Wnt-beta-catenin signaling pathway in gastric cancer. PMID: 25701461
  6. our study suggested that downregulation of VGLL4 was very important in the progression of ESCC, and restoring the function of VGLL4 might be a promising therapeutic strategy for ESCC. PMID: 25352025
  7. VGLL4 directly competes with YAP in binding to TEADs and executes its growth-inhibitory function through two TDU domains. PMID: 24458094
  8. rs2616551 in VGLL4 was found to be nominally associated with anorexia nervosa. PMID: 24983835
  9. This study introduces a novel gain-of-function approach for studying hESC maintenance and presents VGLL4 as a previously undescribed regulator of this process. PMID: 23765749
  10. Loss of VGLL4 expression is associated with gastric cancer. PMID: 24525233
  11. Vgl-4 may play a role in the apoptotic pathways by regulating translocation of IAPs between different cell compartments. PMID: 21839727
  12. IRF2BP2 was identifies as a novel VGLL4 partner. PMID: 20702774
  13. Vgl-4 modulates the activity of TEF-1 factors and counteracts alpha1-adrenergic activation of gene expression in cardiac myocytes PMID: 15140898
  14. A transcriptional cofactor of transcriptional enhancer factor-1 (TEF-1) transcription factors. Interacts with TEF-1 factors through 2 TDU (tondu) motifs. Controls gene expression in cardiac myocytes. PMID: 15140898
  15. This gene is named Vestigial-like 4, to distinguish it from 3 previously described genes Vgl-1, Vgl-2 and Vgl-3. Contains 2 motifs, found in the Drosophila transcription cofactor Vestigial, that interact with the TEF-1 family of transcription factors. PMID: 15140898

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Subcellular Location Nucleus.
Protein Families Vestigial family
Database Links

HGNC: 28966

KEGG: hsa:9686

STRING: 9606.ENSP00000404251

UniGene: Hs.740389

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