VGLL4 Antibody

Code CSB-PA613487LA01HU
Size US$166
Order now
Image
  • Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA613487LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human melanoma using CSB-PA613487LA01HU at dilution of 1:100

The Latest Promotion Free Antibody trial simple
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) VGLL4 Polyclonal antibody
Uniprot No.
Target Names
VGLL4
Alternative Names
VGLL4 antibody; KIAA0121 antibody; Transcription cofactor vestigial-like protein 4 antibody; Vgl-4 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Transcription cofactor vestigial-like protein 4 protein (43-277AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The VGLL4 Antibody (Product code: CSB-PA613487LA01HU) is Non-conjugated. For VGLL4 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA613487LB01HU VGLL4 Antibody, HRP conjugated ELISA
FITC CSB-PA613487LC01HU VGLL4 Antibody, FITC conjugated
Biotin CSB-PA613487LD01HU VGLL4 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
May act as a specific coactivator for the mammalian TEFs.
Gene References into Functions
  1. Hippo pathway transcription factor TEAD4 directly associates with the Wnt pathway transcription factor TCF4 via their DNA-binding domains, forming a complex on target genes. VGLL4 binds to this TEAD4-TCF4 complex to inhibit transactivation of both TCF4 and TEAD4. PMID: 28051067
  2. Results identify VGLL4 as a direct target gene of miR-130b in Bladder cancer (BCa) cells. Its suppression is crucial for miR-130b-induced BCa cell proliferation, migration and invasion. PMID: 29512748
  3. The Vgll4 is phosphorylated in vitro and in vivo by cyclin-dependent kinase 1 (CDK1) during antimitotic drug-induced mitotic arrest and also in normal mitosis. PMID: 28739871
  4. VGLL4 - novel candidate genes validated in a large case-control sample of schizophrenia. PMID: 26460480
  5. The expression level of VGLL4 protein was down-regulated in gastric cancer tissues.VGLL4 inhibits epithelial-mesenchymal transition in part through suppressing Wnt-beta-catenin signaling pathway in gastric cancer. PMID: 25701461
  6. our study suggested that downregulation of VGLL4 was very important in the progression of ESCC, and restoring the function of VGLL4 might be a promising therapeutic strategy for ESCC. PMID: 25352025
  7. VGLL4 directly competes with YAP in binding to TEADs and executes its growth-inhibitory function through two TDU domains. PMID: 24458094
  8. rs2616551 in VGLL4 was found to be nominally associated with anorexia nervosa. PMID: 24983835
  9. This study introduces a novel gain-of-function approach for studying hESC maintenance and presents VGLL4 as a previously undescribed regulator of this process. PMID: 23765749
  10. Loss of VGLL4 expression is associated with gastric cancer. PMID: 24525233
  11. Vgl-4 may play a role in the apoptotic pathways by regulating translocation of IAPs between different cell compartments. PMID: 21839727
  12. IRF2BP2 was identifies as a novel VGLL4 partner. PMID: 20702774
  13. Vgl-4 modulates the activity of TEF-1 factors and counteracts alpha1-adrenergic activation of gene expression in cardiac myocytes PMID: 15140898
  14. A transcriptional cofactor of transcriptional enhancer factor-1 (TEF-1) transcription factors. Interacts with TEF-1 factors through 2 TDU (tondu) motifs. Controls gene expression in cardiac myocytes. PMID: 15140898
  15. This gene is named Vestigial-like 4, to distinguish it from 3 previously described genes Vgl-1, Vgl-2 and Vgl-3. Contains 2 motifs, found in the Drosophila transcription cofactor Vestigial, that interact with the TEF-1 family of transcription factors. PMID: 15140898

Show More

Hide All

Subcellular Location
Nucleus.
Protein Families
Vestigial family
Database Links

HGNC: 28966

KEGG: hsa:9686

STRING: 9606.ENSP00000404251

UniGene: Hs.740389

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
webinars: DT3C facilitates antibody internalization X
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*