Recombinant Human Transcription factor 21 (TCF21)

1. TCF21 inhibits gastric cancer growth and chemoresistance possibly through the AKT signaling pathway PMID: 30296564
2. we concluded that decreased mRNA expression of TCF21 is a predictor for poor prognosis in patients with lung adenocarcinoma. PMID: 28515486
3. TCF21 is downregulated in ESCC, and its low expression is closely correlated with N stage and predicts a poor prognosis. TCF21 functions as a tumor suppressor in ESCC progression, and enhancement of its expression levels may be partly through promoting Kiss-1 expression to reverse EMT by modulating EMT-related gene expression. PMID: 29909422
4. TCF21 modulates Steroidogenic factor-1 and estrogen receptor beta expression through the recruitment of USF2 in endometriotic stromal cells. PMID: 30018006
5. TCF21, a hypoxia-driven p53 target, functions as a tumor suppressor in uterine corpus endometrial cancer and presents as a therapeutic target for tumor treatment. PMID: 29608330
6. Genetic polymorphisms of TCF21 are potentially predictive for osteosarcoma risk and outcomes. PMID: 28663539
7. TCF21 rs12190287 polymorphism can regulate TCF21 expression and may serve as a potential marker for genetic susceptibility to breast cancer. PMID: 27270650
8. There were significant differences in the genotype and allele frequencies of rs12190287 between the cases and controls in a Chinese population. Allele G of rs12190287 was significantly associated with an increased risk of Ventricular Septal Defects in a Chinese population. PMID: 28346832
9. Transcription Factor 21 is downregulated in adrenocortical carcinoma cells. Taken together, these findings support the hypothesis that Transcription Factor 21 is a regulator of steroidogenic factor 1 and is a tumor suppressor gene in pediatric and adult adrenocortical tumors. PMID: 28658440
10. TCF21 binds to AHR, promotes expression of AHR to upregulate inflammation-related genes in coronary artery smooth muscle. PMID: 28481916
11. Association of miR-146a rs2910164 and TCF21 rs12190287 with CAD in an Iranian population. PMID: 26909569
12. These findings show that POD-1/TCF21 regulates SF-1 and LRH-1 by distinct mechanisms, contributing to the understanding of POD-1 involvement and its mechanisms of action in adrenal and liver tumorigenesis. PMID: 26421305
13. TCF21 may function as a tumor suppressor gene, which is downregulated through promoter hypermethylation in CRC development. PMID: 26435499
14. The presence of significant hypermethylation of TCF21 supports the hypothesis that hypermethylation of TCF21 and/or decreased TARID expression lies within the pathogenic pathway of most CCSKs. PMID: 26158413
15. our data provided the first evidence that TCF21 mRNA is significantly downregulated in breast cancer cell lines and tissues and regulates breast cancer cell proliferation and EMT. PMID: 26044559
16. Separate enrichment analyses found over-representation of TCF21 target genes among CAD associated genes, and linkage disequilibrium between TCF21 peak variation and that found in GWAS loci consistent with the hypothesis that TCF21 may affect disease risk PMID: 26020271
17. TCF21 could inhibit the proliferation and migration of SMMC-7721 hepatocellular carcinoma cells and promote its apoptosis PMID: 26146055
18. Low TCF21 expression is associated with gastric cancer. PMID: 25156819
19. TCF21 inhibits the proliferation and migration and facilitates early apoptosis of A549 cells. PMID: 24758904
20. these data suggest that miR-224 interaction with the TCF21 transcript contributes to allelic imbalance of this gene, thus partly explaining the genetic risk for coronary heart disease associated at 6q23.2 PMID: 24676100
21. Results show that TARID, an antisense lncRNA activates TCF21 expression by inducing promoter demethylation. PMID: 25087872
22. These findings, together with its stage- and primary site-dependent expression, turn TCF21 into a promising candidate biomarker in head and neck squamous cell carcinoma. PMID: 23529585
23. Thus, both disease-related growth factor and embryonic signaling pathways may regulate CHD risk through two independent alleles at TCF21. PMID: 23874238
24. study found that POD-1/TCF21 acts as a transcriptional suppressor of SF-1 gene expression in adrenocortical carcinoma cells; a possible mechanism involved in repression of SF-1 expression is through POD-1 binding to the E-box sequence in the SF-1 promoter region PMID: 23313103
25. demonstrated that TCF21 was a significant prognosticator of cancer-specific survival PMID: 22862160
26. Epigenetic downregulation of TCF21 is functionally involved in melanoma progression. PMID: 21771727
27. Hypermethylation and decreased expression of TCF21 were tumor specific and very frequent in all NSCLCs, even early-stage disease. PMID: 20945327
28. epicardin/capsulin/Pod-1 functions as a negative regulator of differentiation of myoblasts through transcription in cell growth arrest and lineage-specific differentiation PMID: 12493738
29. analysis of TCF21 epigenetic regulation on 6q23-q24 in lung and head and neck cancer PMID: 16415157

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HGNC: 11632

OMIM: 603306

KEGG: hsa:6943

STRING: 9606.ENSP00000237316

UniGene: Hs.78061