Recombinant Human Transmembrane protein 98 (TMEM98)

Code CSB-EP023901HU
MSDS
Size $224
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  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Product Details

Purity
Greater than 90% as determined by SDS-PAGE.
Target Names
TMEM98
Uniprot No.
Research Area
Cell Biology
Alternative Names
TMEM98; UNQ536/PRO1079; Transmembrane protein 98; Protein TADA1
Species
Homo sapiens (Human)
Source
E.coli
Expression Region
25-226aa
Target Protein Sequence
LVCRQRYCRPRDLLQRYDSKPIVDLIGAMETQSEPSELELDDVVITNPHIEAILENEDWIEDASGLMSHCIAILKICHTLTEKLVAMTMGSGAKMKTSASVSDIIVVAKRISPRVDDVVKSMYPPLDPKLLDARTTALLLSVSHLVLVTRNACHLTGGLDWIDQSLSAAEEHLEVLREAALASEPDKGLPGPEGFLQEQSAI
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight
26.2kDa
Protein Length
Full Length of Mature Protein
Tag Info
N-terminal 6xHis-tagged
Form
Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation. The secreted form promotes differentiation of T helper 1 cells (Th1).
Gene References into Functions
  1. siRNA-TMEM98 inhibited the invasion and migration of non-small cell lung cancer cells. PMID: 26884835
  2. Two novel TMEM98 mutations have been found in two pedigrees with autosomal dominant nanophthalmos. PMID: 26392740
  3. we identified a panel of novel common chemoresistance-associated genes and demonstrated that TMEM98 is a chemoresistance-conferring gene in hepatocellular carcinoma. PMID: 24608572
  4. A novel gene associated with nanophthalmos, TMEM98 most likely represents the cause of the disease. PMID: 24852644
Involvement in disease
Nanophthalmos 4 (NNO4)
Subcellular Location
Cell membrane; Single-pass type II membrane protein. Secreted. Secreted, extracellular exosome. Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein Families
TMEM98 family
Tissue Specificity
Widely expressed with high expression in the ovary, pancreas and prostate. Expressed in the eye, particularly in corneal endothelium, iris, ciliary body, sclera, optic nerve, optic nerve head, and retina. Expressed by activated peripheral blood mononuclea
Database Links

HGNC: 24529

OMIM: 615949

KEGG: hsa:26022

STRING: 9606.ENSP00000378138

UniGene: Hs.3447

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