Recombinant Human UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter (SLC35D1), partial

Code CSB-YP889109HU
MSDS
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Source Yeast
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Code CSB-EP889109HU
MSDS
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Source E.coli
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Code CSB-EP889109HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP889109HU
MSDS
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Source Baculovirus
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Code CSB-MP889109HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
SLC35D1
Uniprot No.
Alternative Names
KIAA0260; MGC138236; S35D1_HUMAN; SLC35D1; Solute carrier family 35 (UDP GlcA/UDP GalNAc transporter); member D1; Solute carrier family 35 (UDP glucuronic acid/UDP N acetylgalactosamine dual transporter); member D1; Solute carrier family 35 member D1; UDP galactose transporter related 7; UDP-galactose transporter-related protein 7; UDP-GlcA/UDP-GalNAc transporter; UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter; UGTrel7
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Transports both UDP-glucuronic acid (UDP-GlcA) and UDP-N-acetylgalactosamine (UDP-GalNAc) from the cytoplasm into the endoplasmic reticulum lumen. Plays a role in chondroitin sulfate biosynthesis, which is important for formation of cartilage extracellular matrix and normal skeletal development.
Gene References into Functions
  1. there is a positive association between the GWAS reported rs3762318 and leprosy, and SLC35D1 and IL23R might be the causal genes PMID: 27712858
  2. Loss of function mutations cause Schneckenbecken dysplasia, a severe skeletal dysplasia. PMID: 17952091
  3. Searched for SLC35D1 mutations, identified four novel mutations in three Schneckenbecken dysplasia families. All mutations result in loss of function. No SLC35D1 mutations were id'd in all patients with other spondylodysplastic dysplasias group diseases. PMID: 19508970
Involvement in disease
Schneckenbecken dysplasia (SCHBCKD)
Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein Families
TPT transporter family, SLC35D subfamily
Tissue Specificity
Ubiquitous.
Database Links

HGNC: 20800

OMIM: 269250

KEGG: hsa:23169

STRING: 9606.ENSP00000235345

UniGene: Hs.213642

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