Recombinant Human UDP-glucuronosyltransferase 1A7 (UGT1A7), partial

1. high activity UGT1A7 genotype is associated with an increased risk for Warthin's tumor. PMID: 25899702
2. Increased UGT1A7 expression is associated with pancreatic cancer. PMID: 25743847
3. The rate of Results show that UGT1A7*12 allele frequency was not significantly different between the Uzbek and Japanese populations. PMID: 24453052
4. The presence of UGT1A1*28, UGT1A7*3, UGT1A9*22 genotypes decreases SN-38 clearance between 20 and 36% PMID: 23789755
5. Results suggest that CYP3A4 changes the catalytic function of the UGT1A subfamily in a UGT isoform-specific manner. PMID: 24255116
6. Polymorphism in UDP-glucuronosyltransferase 1A7 is associated with colorectal cancer. PMID: 22901212
7. the UGT1A7*3 allele is a risk factor for cancer among Asians, especially for hepatocellular carcinoma (Meta-Analysis) PMID: 22402308
8. there is a cancer risk associated with UGT1A7*3, Intermediate, and Low activity UGT1A7 genotypes, which is most evident in Asian individuals. PMID: 22085268
9. UGT1A7 variants play a relevant role for pancreas diseases PMID: 21440586
10. 7-fold increased risk of cancer was observed in smokers with UGT1A7 low activity genotypes. UGT1A7 haplotype carrying C allele (T622C) showed 10-fold increased risk of cancer. PMID: 20534012
11. UGT1A7 heterozygosity predicted lower mycophenolic acid (MPA) trough concentrations. PMID: 20567810
12. In a study of Japanese renal transplant recipients, there are no significant differences in the area under the plasma concentration-time curve ratio of mycophenolic acid (MPA) glucuronide/MPA between UGT1A7 I399C/T genotypes. PMID: 18695635
13. The genetic polymorphisms of UGT1A7 are associated with the susceptibility of bladder cancer and have interactions with smoking in bladder carcinogenesis. PMID: 20193274
14. Data identified nine different genotypes in UGT1A7, demonstrating a high variability of alleles and haplotypes, which have important roles in modifying expression and activity of UGTs. PMID: 19712005
15. Frequent haplotypes containing several UGT1 allelic variants should be taken into account in studies on the association between diseases, abnormal drug reactions, and UGT1 family polymorphisms. PMID: 12732365
16. UGT1A7 polymorphisms together with IL-1 beta have a role in hepatocellular carcinoma in Japanese Hepatitic C virus-infected patients PMID: 15073122
17. Genetic polymorphisms in UGT1A7 is associated with colorectal cancer PMID: 15319294
18. the allele frequencies of UGT1A7 gene in Taiwan Chinese are different from those in Caucasians and Japanese PMID: 15682470
19. carriage of the UGT1A7*3 allele, as well as variant-211 UGT1A1 allele represents a risk factor for the development of, and a determinant for, metastases associated with colorectal cancer patients PMID: 15929176
20. UDP-glucuronosyltransferase 1A7 genetic polymorphisms are associated with hepatocellular carcinoma risk and onset age. PMID: 16086712
21. UGT1A7 polymorphisms do not predispose patients to the development of pancreatic cancer and pancreatitis PMID: 16199544
22. UGT1A7 polymorphisms may have a significant modifying effect on colorectal cancer risk. PMID: 16724991
23. analysis of the linkage disequilibrium of UGT1A1 *6 and UGT1A1 *28 in relation to UGT1A6 and UGT1A7 polymorphisms PMID: 16969497
24. most of the previously reported genetic associations between UGT1A7 and gastrointestinal cancers are based on primer-dependent genotyping errors PMID: 17325733
25. Genetic linkage of UGT1A7 and UGT1A9 polymorphisms to UGT1A1*6, related to reduced catalytic and transcriptional activities of UGTs, is associated with the decreased glucuronosyltransferase activity for SN-38 in Japanese PMID: 17406868
26. UGT1A1 and UGT1A7 variant alleles are associated with increased risk of Gilbert's syndrome in Taiwanese adults PMID: 17850628
27. Our study shows that UGT1A7 may play a role in hepatocellular carcinogenesis and that this role may differ according to the primary cause of the cirrhosis. PMID: 18021430
28. This study demonstrates the novel findings that carriage of low-activity UGT1A7 genotypes represents a risk factor for the development and functional severity of liver cirrhosis. PMID: 18054330
29. the UGT1A7 haplotype is a suitable susceptibility marker for the development of hepatocellular carcinoma in hepatitis B carriers. PMID: 18271934
30. Irenotecan toxicity is more likely in patients with Gilbert's syndrome carrying the UGT1A1*28 allele combined with reduced function UGT1A7 N129K/R131K and UGT1A7-57T/G SNP. PMID: 18349289
31. Predicted high activity UGT1A7 polymorphisms were significantly associated with an increased risk of head and neck cancer. PMID: 19360737
32. UGT1A variants additional to UGT1A1*28 might improve the prediction of the outcome of colorectal cancer patients treated with FOLFIRI. PMID: 19364970
33. Polymorphisms of UGT1A7 gene may alter the severity of PAH-induced chromosomal damage among the exposed workers. PMID: 19430315
34. Uncategorized study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 19956635
35. Observational study of gene-disease association, gene-gene interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 18349289
36. Observational study of genotype prevalence and genetic testing. (HuGE Navigator) PMID: 15682470
37. Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 15709193

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HGNC: 12539

OMIM: 191740

KEGG: hsa:54577

STRING: 9606.ENSP00000362525

UniGene: Hs.554822