Recombinant Human Uncharacterized protein C6orf106 (C6orf106)

Code CSB-YP863990HU
MSDS
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Source Yeast
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Code CSB-EP863990HU
MSDS
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Source E.coli
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Code CSB-EP863990HU-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP863990HU
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP863990HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
C6orf106
Uniprot No.
Alternative Names
C6orf106; CF106_HUMAN; Chromosome 6 open reading frame 106; dJ391O22.4; FLJ22195; RP3-391O22.4; Uncharacterized protein C6orf106
Species
Homo sapiens (Human)
Expression Region
1-298
Target Protein Sequence
MEGMDVDLDP ELMQKFSCLG TTDKDVLISE FQRLLGFQLN PAGCAFFLDM TNWNLQAAIG AYYDFESPNI SVPSMSFVED VTIGEGESIP PDTQFVKTWR IQNSGAEAWP PGVCLKYVGG DQFGHVNMVM VRSLEPQEIA DVSVQMCSPS RAGMYQGQWR MCTATGLYYG DVIWVILSVE VGGLLGVTQQ LSSFETEFNT QPHRKVEGNF NPFASPQKNR QSDENNLKDP GGSEFDSISK NTWAPAPDTW APAPDQTEQD QNRLSQNSVN LSPSSHANNL SVVTYSKGLH GPYPFGQS
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Negative regulator of innate antiviral response. Blocks IRF3-dependent cytokine production such as IFNA, IFNB and TNF. Interacts with IRF3 and inhibits IRF3 recruitment to type I IFN promoter sequences while also reducing nuclear levels of the coactivators EP300 and CREBBP.
Gene References into Functions
  1. High C6orf106 expression was significantly correlated with lymph node metastasis in triple-negative breast cancer. PMID: 25953261
  2. C6orf106 promotes invasion in NSCLC cells. Finally, C6orf106 upregulates vimentin, and downregulates E-cadherin and P120ctn. PMID: 25736925
  3. Ethanol, but not acetaldehyde, inhibited PPAR-beta transactivation. PMID: 18003597
  4. DSCR2 was found to interact with PPARbeta and to inhibit it. PMID: 18793612
  5. up-regulated expression by repetitive low-grade oxidative stress through p38MAPK or NF-kappaB pathways PMID: 19059477

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Subcellular Location
Cytoplasm. Nucleus.
Tissue Specificity
Expressed in lung (at protein level).
Database Links

HGNC: 21215

OMIM: 612217

KEGG: hsa:64771

STRING: 9606.ENSP00000363135

UniGene: Hs.643498

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