Recombinant Human Urea transporter 1 (SLC14A1), partial

1. The urea transporter subtypes, UT-A1 and UT-B1, were expressed in the skin basal cell layer and exocrine sweat glands. The abundance of UT-A1 and UT-B1 in uremic sweat glands was significantly increased in UP, while the expression of AQP5 was decreased. PMID: 29279852
2. In addition to the well known Polynesian Jknull allele, three Jknull alleles were detected including one novel Jknull allele: JKA (130A, 220G). PMID: 26969102
3. The Jk(a-b-) phenotype in the Chinese population shows several different molecular mechanisms. A novel missense mutation nt737T>G of JK gene was found as associated with Jk(a-b-) phenotype. PMID: 25807964
4. Data indicate that urea transporter UT-A1 successfully trafficking to the apical membrane of the epithelial cells is crucial for the regulation of urea transport. PMID: 23698785
5. Results suggested that polymorphism in TERTC/T and SLC14A1C/T confirmed high risk for BC in North Indian population. PMID: 25218484
6. Reduction or loss of UT-B expression may be related to the incidence, progression and invasiveness of bladder urothelial carcinoma. PMID: 25445116
7. Studies indicate that expression of urea transporter UT-B confers high urea permeability to erythrocytes. PMID: 25298342
8. Studies indicate that acid substitution in the urea transporter Slc14A1 UT-B protein determines the erythrocyte Kidd blood group antigen. PMID: 25298346
9. UT-B should be considered as a new member of the water channel family. PMID: 24376529
10. High-throughput Kell, Kidd, and Duffy matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry-based blood group genotyping of 4000 donors shows close to full concordance with serotyping and detects new alleles. PMID: 24845979
11. these data confirm the presence of UT-B protein within the human bladder. PMID: 25209859
12. Novel polymorphisms in exon 9 of the JSLC14A1 gene in Japanese individuals associated with the Jk(a-b-) phenotype. PMID: 24877238
13. Thienoquinoline PU-14 is a selective UT inhibitor and has urea-selective diuretic activity. PMID: 23486518
14. SLC14A1 could be a unique urea transporter in the bladder that has the ability to influence urine concentration and that this mechanism might explain the increased bladder cancer susceptibility associated with rs10775480. PMID: 23754249
15. Inhibitor and mutagenesis studies and results of molecular dynamics simulations suggest that NH and HO pass through the three monomeric urea channels in UT-B. PMID: 23552862
16. Four novel JK-null alleles were noted to be associated with the Jk(a-b-) phenotype. PMID: 22738189
17. the rate of urea conduction in UT-B is increased by hypoosmotic stress, and the site of osmoregulation coincides with the location of the energy barrier PMID: 22733730
18. Loss of SLC14A1 is associated with lung adenocarcinoma. PMID: 22223368
19. rs17674580, or other sequence variants of SLC14A1, indirectly modifies urinary bladder cancer risk by affecting urine production. PMID: 21750109
20. Genetic variation in SLC14A1 could provide new etiological insights into bladder carcinogenesis. PMID: 21824976
21. A new allele JK*01W has 3 changes (130G>A, 588A>G, Intron 9-46a>g)in addition to 838G. It is associated with weak expression of the Jk-a antigen on erythrocytes. PMID: 21309779
22. Results illustrate differential protein abundance of functional UT-B protein in different sections of the human colon, strongly correlating to regions that contain the largest populations of intestinal bacteria. PMID: 19926813
23. gene encodes the Kidd blood group antigens PMID: 12093813
24. Kidd antigen/UT-B urea transporter is physiologically expressed in the human colon epithelium, where it could participate in the transport of urea across the colon mucosa. PMID: 14985236
25. high frequency of JK null allele in Taiwanese indigenous groups PMID: 18713105
26. Three blood group antigens genes, namely CD55, CD151, and SLC14A1, have been subjected to balancing selection, a process, rare outside MHC genes, which maintains variability at a locus. PMID: 18997004

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HGNC: 10918

OMIM: 111000

KEGG: hsa:6563

STRING: 9606.ENSP00000390637

UniGene: Hs.101307