Recombinant Human V-type proton ATPase 116 kDa subunit a isoform 1(ATP6V0A1) ,partial

Code CSB-YP846292HU
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Source Yeast
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Code CSB-EP846292HU
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Source E.coli
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Code CSB-EP846292HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP846292HU
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Source Baculovirus
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Code CSB-MP846292HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names ATP6V0A1
Uniprot No. Q93050
Alternative Names a1; ATP6N1; ATP6N1A; ATP6V0A1; ATPase H+ transporting lysosomal (vacuolar proton pump) non catalytic accessory protein 1A (110/116kD); ATPase H+ transporting lysosomal non catalytic accessory protein 1 (110/116kD); ATPase H+ transporting lysosomal V0 subunit a1; ATPase H+ transporting V0 subunit a1; ATPase, H+ transporting, lysosomal, noncatalytic accessory protein 1A; Clathrin coated vesicle/synaptic vesicle proton pump 116 kDa subunit; Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit; DKFZp781J1951; H(+) transporting two sector ATPase 116 kDa accessory protein A1; Stv1; V ATPase 116 kDa; V ATPase 116 kDa isoform a1; V type proton ATPase 116 kDa subunit a; V type proton ATPase 116 kDa subunit a isoform 1; V-ATPase 116 kDa isoform a1; V-type proton ATPase 116 kDa subunit a isoform 1; Vacuolar adenosine triphosphatase subunit Ac116; Vacuolar proton pump subunit 1; Vacuolar proton pump, subunit 1; Vacuolar proton translocating ATPase 116 kDa subunit A; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1; Vacuolar type H(+) ATPase 115 kDa subunit; Vph1; VPP1; VPP1_HUMAN
Species Homo sapiens (Human)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle.
Gene References into Functions
  1. The function of vacuolar ATPase (V-ATPase) a subunit isoforms in invasiveness of MCF10a and MCF10CA1a human breast cancer cells. PMID: 24072707
  2. Inhibition of lysosome degradation on autophagosome formation and responses to GMI, an immunomodulatory protein from Ganoderma microsporum. ATP6V0A1 plays an important role in mediating autophagosome-lysosome fusion. PMID: 22708544
  3. a series of events whereby ATP6V0A1 3'-UTR variant T+3246C functioned: ATP6V0A1 expression probably was affected through differential micro-RNA effects, altering vacuolar pH and consequently CHGA processing and exocytotic secretion. PMID: 21558123
  4. The mRNA levels of POLR2F, ATP6V0A1 and PRNP were evaluated by quantitative RT-PCR in 70 colorectal carcinomas and 17 normal tissue specimens and were correlated with clinicopathological parameters. PMID: 18505059
Subcellular Location Cytoplasmic vesicle membrane; Multi-pass membrane protein. Melanosome. Note=Coated vesicle. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Protein Families V-ATPase 116 kDa subunit family
Database Links

HGNC: 865

OMIM: 192130

KEGG: hsa:535

STRING: 9606.ENSP00000264649

UniGene: Hs.463074


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