Recombinant Human Vitamin K-dependent protein Z (PROZ)

1. Polymorphisms of F2, PROC, PROZ, and F13A1 Genes are Associated With Recurrent Spontaneous Abortion in Chinese Han Women. PMID: 29363996
2. Low PZ appears to be an underestimated risk factor for perioperative bleeding. Determination of PZ plasma concentrations might be useful in the preoperative workup in patients with a bleeding history, when detailed clotting analyses remain inconclusive. PMID: 29360177
3. PZ/ZPI polymorphisms do not appear to play an active role in the development of prosthesis heart valve thrombosis. PMID: 29302946
4. Report evidence of a non-linear positive association between PZ level and unexplained stroke, with a directionally consistent association for genetic variants related to PZ levels and cryptogenic stroke. PMID: 27683756
5. Data suggest oxidized lipid vesicles with phosphatidylserine/polyunsaturated fatty acids promote inactivation of ZPI-PZ complex or free ZPI; binding of PZ-complexed or free ZPI to oxidized vesicles mediates inactivation of ZPI (an inhibitor of FXa); blocking heparin- (anticoagulant-)binding site on ZPI interferes with binding to lipid or PZ. (ZPI = protein Z-dependent protease inhibitor; PZ = protein Z; FXa = factor Xa) PMID: 28717005
6. SAA, PROZ, and C4BPB may serve as new potential biomarkers for TB PMID: 28278182
7. Protein Z is a plasma protein involving blood coagulation and inflammation. Low protein Z was found to be associated significantly with acute my.ocardial infarction in coronary atherosclerosis disease patients PMID: 27770663
8. Family-based association study revealed that the G allele of Protein Z rs2273971, and haplotypes GA, CG, and CGA of Protein Z and factor VII had a significant effect on cerebral hemorrhage susceptibility. PMID: 27350683
9. Protein Z G79A AG/AA polymorphism may be a risk factor for thrombosis in systemic lupus erythematosus Egyptian patients. PMID: 26761586
10. There was no significant difference in the clinical features of the patients with and without the polymorphism. We therefore conclude that PZ G79A polymorphism is not a risk factor for puerperal CVT in Indian women. PMID: 24907135
11. Results show the energetic basis of the Z-dependent protease inhibitor (ZPI)-protein Z (PZ) interaction and suggest an important role for ZPI Lys-239 in PZ catalytic action. PMID: 25713144
12. The unbalance between PZ and ZPI in plasma samples from patients with Colorectal Cancer or Pancreatic Cancer is not only related to an inflammatory state but could also results from an ectopic synthesis of these proteins by the cancer cells. PMID: 24315319
13. Protein Z EGF2 subdomain constitutes an interactive-site for ZPI protein. PMID: 24960590
14. Protein Z/protein Z-dependent protease inhibitor and Fxa expression in human gastric cancer cells indicate that these proteins may play a role in anticoagulant events at the tumor tissue. PMID: 24158387
15. active mutations of PZ in the serine protease structural domain were found in women with fetal loss PMID: 23846529
16. Data suggest role for complex of PZ with ZPI (PZ-dependent protease inhibitor) in pregnancy maintenance; this is highlighted by progressive elevation in PZ levels in first trimester of gestation which then steadily decline toward delivery. [REVIEW] PMID: 23690629
17. Specific PZSNPs and haplotypes are significantly associated with idiopathic recurrent miscarriage. PMID: 23420821
18. the PZ/ZPI complex may play some modulating role in hemophilia A PMID: 23269381
19. 74 patients a protein Z deficiency has been found. PMID: 22960740
20. PZ can be a cofactor associated with an increased bleeding tendency in patients with AML. PMID: 22297560
21. expression of PROZ in PLC/PRF/5 cells increased cell viability and clonogenicity compared to mock-transfected cells. PMID: 22689435
22. The study shows by Ala-scanning mutagenesis of the ZPI-binding interface, together with native PAGE and kinetic analyses of PZ binding to ZPI, that Tyr240 and Asp293 of ZPI are crucial hot spots for PZ binding. PMID: 22786881
23. Specific PZ variants and haplotypes are significantly associated with Sickle cell disease Vaso-Occlusive Crisis. PMID: 22576309
24. Although thrombosis in Behcet disease is multifactorial, intron F G79A polymorphism of PZ gene in Behcet disease may be one of the factors that contribute to this pathological process PMID: 22559296
25. Medium expression of ZPI(IRS=6.5), together with weak expression of PZ(IRS=4), was observed in cancer cells. PMID: 21975032
26. localization of PZ/ZPI and FX in colon cancer cells indicates that PZ/ZPI may contribute to anticoagulant events at the tumor site. PMID: 22424030
27. The objective of this study was to measure the PZ levels in pregnant Omani women in the first, second and third trimesters and correlate with the pregnancy outcome. PMID: 21837382
28. it was shown that PZ and/or ZPI are synthesised by normal kidney and different cancer cells, suggesting that the complex PZ/ZPI could play a role in inhibiting the tissue deposition of fibrin. [review] PMID: 21691673
29. The presence of the A allele of the PZ FG79A polymorphism has a higher protective effect against recurrent pregnancy loss than the presence of the G allele of the IL6 C634G polymorphism. PMID: 21233768
30. Protein Z (PZ) expression in breast cancer cells in association with tumor infiltrating macrophages (TAMs) and endothelial cells may suggest possible PZ contribution to natural anticoagulant mechanisms operating at the tumor site. PMID: 21479979
31. Low PZ levels are associated with the pathobiology of HELLP syndrome. PMID: 20460354
32. The frequency of intron F G79A polymorphism of protein Z gene was higher in patients than controls, and carrying 79 AA genotype could be a risk factor for severe sepsis and septic shock. PMID: 19124455
33. the roles of PZ plasma level and PZ gene polymorphisms remain debated with conflicting results in arterial, venous, or placental thrombosis PMID: 20416992
34. Data show that mutation of four ZPI contact residues eliminated PZ binding and membrane-dependent PZ acceleration of fXa inhibition. PMID: 20427285
35. Results of this meta-analysis are consistent with a role for protein Z deficiency in thrombotic diseases, including arterial thrombosis, pregnancy complications and venous thromboembolism. PMID: 20076855
36. PROTEIN A AND PZI WERE FOUND IN KIDNEY TUBULES BY IMMUNOHISTOCHEMISTRY PMID: 20024489
37. Premature newborns suffering from respiratory distress syndrome showed decreased serum protein Z levels than normal preterm control newborns with further increase in its pattern after recovery. PMID: 20180321
38. The distribution of allele and genotype frequencies of Protein Z A-13G and G79A polymorphisms did not differ significantly between Behcets disease patients and controls; no associations between thrombotic events protein Z gene polymorphisms PMID: 19796528
39. Weak regulation of protein Z biosynthesis by inflammatory cytokines indicates that it is not a negative acute-phase protein. Plasma PZ concentration is genetically controlled. PMID: 11858503
40. case control studies in humans indicating that diminution of protein Z in factor V Leiden patients aggravates thromboembolic risk PMID: 12297123
41. Low plasma protein Z values were significantly associated with ischemic stroke except in diabetic subjects and females PMID: 12490280
42. enhanced immune-complex formation with protein Z may play a role in unexplained embryo losses PMID: 12623836
43. Blood levels of protein Z measured within 7 days of acute stroke were significantly higher in cases than in controls (geometric mean, 1.46 versus 1.16 microg/mL; P<0.0001, consistent with its importance in ischemic stroke or as an acute phase reactant PMID: 12970515
44. There is a positive correlation between the disease duration and protein Z levels in patients with Behcet's disease PMID: 14507116
45. PZ levels below 565 ng/mL were associated with ACS PMID: 14652653
46. The A allele of an intron F polymorphism of the PZ gene appears to be a novel protective genetic marker for the risk of cerebral ischemia in young adults. In the context of juvenile stroke, high PZ plasma levels may represent a prothrombotic condition PMID: 14671240
47. protein Z deficiency could be also a risk factor for acute coronary syndromes, early fetal losses, and increased the arterial risk in antiphospholipid syndrome--REVIEW PMID: 15314579
48. Coexpression of E30Q with wild-type protein Z interfered with the secretion of the wild type PMID: 15626740
49. decreased PZ and PS levels are additional risk factors for adverse pregnancy outcome PMID: 15748239
50. data show a progressive increase in protein Z levels with gestational age in normal pregnancies and a return to normal levels around 6 to 12 weeks postpartum PMID: 15841316

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HGNC: 9460

OMIM: 176895

KEGG: hsa:8858

STRING: 9606.ENSP00000364697

UniGene: Hs.1011