Recombinant Human WW domain-containing oxidoreductase (WWOX)

1. We have identified a variant in WWOX and in lncRNA RP11-679B19.1 as a diseasemodifying genetic variant associated with recurrent fibrostenotic CD PMID: 29361163
2. A model is supported in which FRA16D common fragile sites are sequences that may initiate replication in early-mid S phase but are slow to complete replication, and the chromosomal breaks and gaps observed in metaphase cells result from unreplicated DNA. PMID: 14603443
3. Data conclude that WWOX sensitises EOC to paclitaxel via ER stress-induced apoptosis, and predicts clinical outcome in patients. Thus, ER stress response mechanisms could be targeted to overcome chemoresistance in cancer. PMID: 28749468
4. Data show that patients with advanced-stage oral cancer were associated with a higher frequency of WWOX rs11545028 polymorphisms with the variant genotype TT than did patients with the wild-type gene. PMID: 27655721
5. WWOX expression was strongly inhibited in human lung cancers and lung cancer cell lines. Reintroducing WWOX into lung cancer cells inhibited their invasive phenotype through downregulating RUNX2 and its target genes including MMP-9 expression. PMID: 27834355
6. Our data suggests that the deletion genotypes of CNV-67048 in WWOX predispose their carriers to intracranial aneurysms PMID: 26910372
7. It has been proposed that Fhit and Wwox loss work synergistically in cancer progression and that DNA damage caused by Fhit could be targeted early in cancer initiation for prevention, while DNA damage caused by Wwox loss could be targeted later in cancer progression, particularly in cancers that develop resistance to genotoxic therapies. (Review) PMID: 27773744
8. genetic variations in WWOX may be a significant predictor of early HCC occurrence and a reliable biomarker for disease progression PMID: 28426730
9. a WWOX-p53 network regulates normal bone formation and that disruption of this network in osteoprogenitors results in accelerated osteosarcoma. PMID: 27550453
10. Low WWOX expression is associated with Head and Neck Squamous Cell Carcinoma. PMID: 27501229
11. Knockdown of lung WWOX expression in mice was observed to cause neutrophil influx and was accompanied by a corresponding vascular leak and inflammatory cytokine production. In cultured human alveolar epithelial cells, loss of WWOX expression resulted in increased c-Jun- and IL-8-dependent neutrophil chemotaxis toward cell monolayers. PMID: 28283473
12. a portion of ERK and WWOX relocates to the nucleus, suggesting their role in the induction of CD3 and CD8 expression in MOLT-4. PMID: 27339895
13. Brca1-Wwox interaction supports non-homologous end-joining as the dominant DSB repair pathway in Wwox-sufficient cells PMID: 27869163
14. Epigenetic mechanisms influence molecular patterns important for the bone-metastatic process, and this review highlights the role of WW-domain containing oxidoreductase (Wwox). [review] PMID: 28045433
15. the deregulation of microRNA-214-3p expression is involved in a negative feedback loop with WWOX in osteosarcoma, indicating that miR-214-3p has potential basic and clinical implications. PMID: 27840941
16. Functional analyses further showed a lower mRNA level of WWOX in tissues with the 0-copy or 1-copy than that in those with the 2-copy (P = 0.045). Our data suggested the CNV-67048 to be a risk factor of epithelia ovarian cancer in Chinese women. PMID: 27190995
17. WW domain-containing oxidoreductase overexpression promoted apoptosis in 5637 cells and resulted in upregulation of Bax, downregulation of Bcl-2, and elevated levels of cleaved caspase-3 and cleaved PARP, indicating activation of the intrinsic apoptosis pathway. PMID: 27352332
18. The SNP rs383362G >T of WWOX plays a role in chronic obstructive pulmonary disease inheritance. PMID: 26902998
19. a novel SNP in the intron of the WW domain-containing oxidoreductase (WWOX) gene yielded significant replicated associations with skin tanning ability PMID: 26174610
20. WWOX mutation is associated with early infantile epileptic encephalopathy. PMID: 26345274
21. Our data suggest that the loss genotypes of CNV-67048 in WWOX predispose their carriers to chronic obstructive pulmonary disease. PMID: 25517572
22. WWOX played roles in metabolic regulation and controlling central nervous system development. [review] PMID: 26499798
23. Data suggest that Pc2- (polycomb repressive complex 2-) mediated SUMOylation of WWOX is essential for suppressive activity of WWOX in prostate cancer tumorigenesis. PMID: 26592150
24. Compared to the controls, upregulation of WWOX and its Tyr33 phosphorylation was observed in the head region of all pterygium specimens. In the head and body of the pterygium specimens, WWOX expression was significantly higher than in the controls. PMID: 26120275
25. Down regulation of WWOX is involved in tumorigenesis in intrahepatic cholangiocarcinoma. PMID: 25168293
26. Decreased WWOX expression may interfere with gemcitabine sensitivity, and allele-specific binding at rs11644332 might be a causative molecular mechanism behind the clinically observed associations. PMID: 26857392
27. Hypermethylation of WWOX gene is associated with Epstein-Barr virus-associated gastric carcinomas. PMID: 25720522
28. The WWOX gene can downregulate the expression levels of cell cycle proteins cyclin E-CDK2 and cyclin D1-CDK4, which affects the cell cycle of ovarian cancer stem cells. PMID: 25891642
29. The inhibition of the transcriptional activity of BCL9-2 by WWOX and HDAC3 constitutes a new molecular mechanism and provides new insight for a broad range of cancers. PMID: 25678599
30. Results suggest that WWOX gene plays a role in the regulation of epithelial to mesenchymal transition process in endometrial cancer by controlling the expression of proteins associated with cell motility and suppressing mesenchymal markers. PMID: 25892250
31. HGF and TGFbeta1 of bone-metastasis microenvironment acted co-ordinately, influencing non redundant pathways regulated by Twist program or Snail-transcription factor, with reversible MET switch PMID: 26041563
32. miR-153 inhibited protein level of WWOX, a tumor suppressor and inhibitor of beta-catenin signaling, through targeting its 3'-untranslated region. PMID: 25708809
33. WWOX inhibits prostate cancer progression through negatively regulating cyclin D1 in cell cycle lead to G1 arrest. PMID: 25659037
34. overexpression of WWOX attenuated miR-134 induced H69 small cell lung cancer cell growth, and promoted cell apoptosis PMID: 26166818
35. Study underscores a key role of allosteric communication in the ability of the WW2 orphan domain to chaperone physiological action of the WW1 domain within the context of the WW1-WW2 tandem module of WWOX. PMID: 25703206
36. Inactivation of WWOX gene contributes to the progression of head and neck squamous cell carcinoma. PMID: 25612104
37. A strong genetic cosegregation between the WWOX gene and the low HDL-C trait observed genetic associations at the chr16q23-24 locus. PMID: 24871327
38. The role of WWOX in EHCC progression. PMID: 25502636
39. WWOX undoubtedly incriminated as a gene for recessive infantile epileptic encephalopathy. PMID: 25411445
40. There are roles of WWOX in the pathogenesis and endocrine therapy of breast cancer. PMID: 25476151
41. WWOX structure gives insights into the functional versatility of this key signaling protein with important implications on its biology. PMID: 25662954
42. Two and more tandem repeats cooperate in binding to their targets, in the well-characterized family of WWOX domains and their corresponding polyproline ligands. PMID: 25710931
43. WWOX plays a role in the development, signaling pathway, prognosis, and treatment response of malignant glioma. PMID: 25432984
44. WWOX is a member of a very interesting family of very large common fragile site genes and functions as a tumor suppressor involved in the development of many cancers. PMID: 25595185
45. Aberrant WWOX expression contributes to the altered metabolism in cancer. PMID: 25595186
46. WWOX can be regarded as a prognostic marker and a candidate molecule for targeted cancer therapies. PMID: 25595191
47. WWOX plays a critical role in normal central nervous system development and disease. PMID: 25416187
48. WWOX is a tumor suppressor gene and is associated with FRA16D locus fragility. PMID: 25538133
49. WWOX has many functions, and its deletion affects cellular metabolism and neoplastic progression. PMID: 25491415
50. WWOX gene is located in FRA16D, the highly affected chromosomal fragile site. PMID: 25681467

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HGNC: 12799

OMIM: 133239

KEGG: hsa:51741

STRING: 9606.ENSP00000457230

UniGene: Hs.461453