Recombinant Human Zinc transporter ZIP8 (SLC39A8), partial

1. the results of the present study suggested that Zip8 was an important regulator of neuroblastoma cell proliferation and migration, indicating that Zip8 may be a potential anticancer therapeutic target and a promising diagnostic biomarker for human neuroblastoma. PMID: 29749445
2. The expression, localization, and function of ZIP8 and other divalent cation transporters within macrophages have important implications for TB prevention and dissemination and warrant further study. [review] PMID: 29120360
3. SLC39A8 deficiency can cause both a type II CDG and Leigh-like syndrome. PMID: 27995398
4. These results indicate that the ZIP8 Ala391-to-Thr391 substitution has an effect on intracellular cadmium accumulation and cell toxicity, providing a potential mechanistic explanation for the association of this genetic variant with blood pressure. PMID: 27466201
5. We identified an association between Crohn's Disease and a missense variant encoding alanine or threonine at position 391 in the zinc transporter solute carrier family 39, member 8 protein (SLC39A8 alanine 391 threonine, rs13107325) and replicated the association with Crohn's Disease in 2 replication cohorts. PMID: 27492617
6. SLC39A8 SNP (rs13107325) was associated with NT-proBNP levels in patients with acute coronary syndrome (ACS). The SLC39A8 SNP was also associated with higher risk of cardiovascular death. PMID: 26908625
7. data provide evidence of positive selection on a schizophrenia risk SNP rs13107325 in the SLC39A8 gene, and we propose a hypothesis about the relationship among positive selection of host alleles, schizophrenia, hypertension, energy intake, and the unique history of Europeans. PMID: 26006263
8. The lead single nucleotide polymorphism (SNP) in the 4q24 locus was rs13107325 (P-value = 5.1 x 10(-11), beta = -0.77), located in an exon of SLC39A8, which encodes a protein involved in manganese and zinc transport. PMID: 26025379
9. Autosomal-recessive intellectual disability with cerebellar atrophy syndrome is caused by mutation of the manganese and zinc transporter gene SLC39A8. PMID: 26637978
10. Polymorphisms in SLC39A14 and SLC39A8 seemed to affect blood cadmium concentrations, for SLC39A14 this effect may occur via differential gene expression. PMID: 24514587
11. Data indicate that the average expression level of zinc transporter Zip2 was significantly higher and zinc transporters Zip6, Zip8 mRNA levels were significantly lower in short stature children than in health controls. PMID: 23921484
12. MicroRNA-488 regulates zinc transporter SLC39A8/ZIP8 during pathogenesis of osteoarthritis PMID: 23688035
13. The zinc transporter SLC39A8 (ZIP8) is a transcriptional target of NF-kappaB and functions to negatively regulate proinflammatory responses through zinc-mediated down-modulation of IkappaB kinase (IKK) activity in vitro. PMID: 23403290
14. data identify ZIP8 as an iron transport protein that may function in iron metabolism. PMID: 22898811
15. findings reveal a role for brain metal homeostasis in psychosis. PMID: 22078303
16. These data are the first to characterize human SLC39A8 (Zip8) and remarkably demonstrate that upregulation of Zip8 is sufficient to protect lung epithelia against TNF-alpha-induced cytotoxicity. PMID: 18390834
17. These results demonstrate the importance of Sp1 in the regulation of ZIP8 expression. PMID: 18556457
18. ZIP8, through control of zinc transport from the lysosome, may provide a secondary level of IFN-gamma regulation in T cells. PMID: 19401385

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HGNC: 20862

OMIM: 608732

KEGG: hsa:64116

STRING: 9606.ENSP00000349174

UniGene: Hs.288034