Recombinant Human herpesvirus 1 Transcriptional regulator ICP22 (US1)

1. study demonstrate interaction of ICP22 with a subset of cellular proteins known to be involved in transcription elongation; determined that ICP22 is required to recruit the FACT complex and other transcription elongation factors to viral genomes and that in the absence of ICP22 viral transcription is globally reduced late in productive infection, due to an elongation defect PMID: 28611249
2. The results indicate that discrete regions of ICP22 interact with either CDK9 or pol II and that ICP22 interacts directly with CDK9 to inhibit expression of host cell genes. PMID: 25233083
3. ICP22 but not US1.5 is required for efficient acute replication in mice and VICE domain formation. PMID: 24089574
4. ICP22 mediates several striking changes to important host nuclear systems, including those involved in RNA polymerase II transcription, cell cycle regulation and protein quality control, promoting productive virus infection. PMID: 23464370
5. ICP22 interacts with and blocks the recruitment of P-TEFb to viral promoter regions, which inhibits transcription of the viral gene promoters. PMID: 23029222
6. It has been shown to be required for efficient expression of early (E) genes and a subset of late (L) genes. PMID: 20960278
7. Data show that VICE domain formation in Vero and other cells requires the HSV-1 immediate-early protein ICP22. PMID: 20032172
8. ICP22, the product of the Us1 gene, is localized to small dense nuclear bodies and is paired with the SC-35 domain in the nucleus, (ii) ICP22 localization in a punctate state requires completion of the main sequence which includes the 1-320th amino acids PMID: 16877770
9. findings show ICP22 is responsible for the loss of RNA polymerase II forms bearing serine 2 phosphorylation during the immediate-early phase of infection PMID: 17344289
10. cdc25C phosphatase plays a role in viral replication and that this role extends beyond its function of activating cdc2 for initiation of the ICP22-dependent cascade for upregulation of gamma(2) gene expression. PMID: 18272575
11. The authors conclude that cdk9 plays a critical role in the optimization of expression of genes regulated by ICP22 and that one function of cdk9 in HSV-1-infected cells may be to bring ICP22 into the RNA Pol II transcriptional complex. PMID: 18753202
12. The results genetically uncouple ICP22's effects on Pol II from its effects on viral late gene expression. This suggests that these two functions of ICP22 may be due to distinct activities of the protein. PMID: 18971282
13. Expression of ICP22 was sufficient to prevent transactivation of reporter genes by ICP0. PMID: 19535441
14. expression of IC22 and of U(S)1.5 can occur independently of each other, and U(S)1.5 translation initiates at M90 of the ICP22 ORF PMID: 19570862

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KEGG: vg:2703435