Recombinant Human mTERF domain-containing protein 2 (MTERFD2)

Code CSB-YP800224HU
MSDS
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Source Yeast
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Code CSB-EP800224HU
MSDS
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Source E.coli
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Code CSB-EP800224HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP800224HU
MSDS
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Source Baculovirus
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Code CSB-MP800224HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
MTERF4
Uniprot No.
Alternative Names
FLJ16261; HSPC096; MGC61716; MTER2_HUMAN; MTERF domain containing 2; mTERF domain-containing protein 2; Mterfd2; OTTHUMP00000200479; OTTHUMP00000200519
Species
Homo sapiens (Human)
Expression Region
43-381
Target Protein Sequence
LTTASNGG VIEELSCVRS NNYVQEPECR RNLVQCLLEK QGTPVVQGSL ELERVMSSLL DMGFSNAHIN ELLSVRRGAS LQQLLDIISE FILLGLNPEP VCVVLKKSPQ LLKLPIMQMR KRSSYLQKLG LGEGKLKRVL YCCPEIFTMR QQDINDTVRL LKEKCLFTVQ QVTKILHSCP SVLREDLGQL EYKFQYAYFR MGIKHPDIVK SEYLQYSLTK IKQRHIYLER LGRYQTPDKK GQTQIPNPLL KDILRVSEAE FLARTACTSV EEFQVFKKLL AREEEESESS TSDDKRASLD EDEDDDDEED NDEDDNDEDD DDEDDDEAED NDEDEDDDEE E
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Regulator of mitochondrial ribosome biogenesis and translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S and targets NSUN4 RNA methyltransferase to the mitochondrial large ribosomal subunit (39S).
Gene References into Functions
  1. The overexpression of MTERF4 induced a significant increase in the levels of APP protein and secreted Abeta 42 in HEK293-APPswe cells compared with control cells these results suggest that MTERF4 promotes the amyloidogenic processing of APP by inhibiting ADAM10 in HEK293-APPswe cells; therefore, MTERF4 may play an important role in the pathogenesis of Alzheimer's disease. PMID: 27894840
  2. analysis of the 3D crystal structure of the human MTERF4-NSUN4 complex PMID: 22949673
Subcellular Location
Mitochondrion.
Protein Families
MTERF family
Database Links

HGNC: 28785

OMIM: 615393

KEGG: hsa:130916

STRING: 9606.ENSP00000241527

UniGene: Hs.159556

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